Walleye dermal sarcoma (WDS) was first described as a multifocal cutaneous neoplasm of walleyes Stizostedion vitreurn in Oneida Lake, New York, USA. The neoplasm was subsequently shown to be caused by a type C retrovlrus. We have successfully transmitted the neoplasm in laboi-atory-maintained young-of-the-year (YOY) ~r a l l e~e s In a number of pathogenesis studies over the past 6 yr. Neoplasms in these laboratory trials were typical of those superficial neoplasms observed in adult feral walleyes. A transmission study was begun summer 1994 uslny 9 \vk old walleyes. S t a r t~n g at 56 d and continuing throughout the experiment, injected fish developed grossly visible, multiple small whlte skin masses that varled from 0.5 to 10 mni in diameter. These masses appeared on the skin of the head, back, flank, fins and lips. Histopathological examination revealed that some of these neoplasms, especially those collected at 84 d and beyond, did not remain cutaneous, but were locally invasive and replaced normal tlssue, primanly muscle. One neoplasm on the head of a young walleye had deformed the brain and had invaded the skull. Due to the unusual invasive nature of the microscopic lesions of the neoplasm, these findings are reported.