Dietary Nucleotides Enhance Plasma Lecithin Cholesterol Acyl Transferase Activity and Apolipoprotein A-IV Concentration in Preterm Newborn Infants

Sánchez–Pozo, Antonio; Ramı́rez, Manuel; Gil, Ángel; Maldonado, J.; Biervliet, J.P. Van; Rosseneu, Maryvonne

doi:10.1203/00006450-199503000-00013

Cited by 33 publications

(23 citation statements)

References 13 publications

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“…High cholesteryl ester transfer protein activity leads to more atherogenic cholesteryl ester-rich VLDL which are catabolised in non hepatic sites such as arterial wall macrophages. Consistent with previous reports [19,28,31], serum lipid and lipoproteins levels increased during the 1st month of life in control infants. These lipoprotein changes are due to increased lipid and apolipoprotein syntheses after birth [28,31].…”

Section: Discussionsupporting

confidence: 93%

“…Consistent with previous reports [19,28,31], serum lipid and lipoproteins levels increased during the 1st month of life in control infants. These lipoprotein changes are due to increased lipid and apolipoprotein syntheses after birth [28,31]. However, in macrosomic infants, despite a rise in apo A-I levels, HDL 2 and HDL 3 amounts increased only slightly during the 1st month of life.…”

Section: Discussionsupporting

confidence: 93%

“…During the 1st month of life, in controls as well as in macrosomic infants, the main changes were an increase in the proportion of C18:2n-6 and a decrease in C20:4n-6 in serum triacylglycerols, cholesteryl esters and phospholipids, which agrees with previous works [28,31]. However, the proportion of the decrease in C20:4n-6 was less in our infants than in those fed standard milk, but was similar to that in those fed breast milk [28,31].…”

Section: Discussionsupporting

confidence: 89%

“…However, the proportion of the decrease in C20:4n-6 was less in our infants than in those fed standard milk, but was similar to that in those fed breast milk [28,31]. In our control newborns, at day 30, C22:6n-3 amounts were maintained at birth levels.…”

Section: Discussionsupporting

confidence: 57%

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Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers

Merzouk

Madani²,

Prost³

et al. 1999

European Journal of Pediatrics

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The aim of this study was to determine whether macrosomia related to maternal diabetes alters lipoprotein metabolism and whether these abnormalities still persist or regress after 1 month of life. Serum lipoprotein compositions and concentrations as well as serum lipid fatty acid compositions were investigated in macrosomic infants (birth weight = 4840 +/- 105 g at term) of insulin-dependent diabetic mothers at birth and after 1 month of life, and were compared to those of control infants (birth weight = 3400 +/- 198 g at term) of healthy mothers. Compared to controls, at birth, macrosomic newborns had higher serum lipids, apolipoprotein A-I and B-100, and lipoprotein (very low density lipoprotein, low density lipoprotein, high density lipoprotein-2 and high density lipoprotein-3) levels. Higher percentages of C18:2n-6 in serum triacylglycerols, phospholipids and cholesteryl esters were also observed. At day 30, in macrosomics, serum triacylglycerol, apo B-100, very low density lipoprotein and low density lipoprotein levels were still significantly higher. C18:2n-6 and C18:3n-3 contents in serum phospholipids, triacylglycerols and cholesteryl esters were reduced while C20:4n-6 and C22:6n-3 contents in serum phospholipids and cholesteryl esters were enhanced, compared to control values. Macrosomia was associated with alterations in lipoprotein compositions and concentrations at birth, some of which persisted after 1 month of life, and might play a role in the pathogenesis of diabetes and atherosclerosis in adult life.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 57%

See 2 more Smart Citations

Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers

Merzouk

Madani²,

Prost³

et al. 1999

European Journal of Pediatrics

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“…Dietary nucleotides play a number of biologic roles, especially in early infancy (2)(3)(4)(5). For example, they influence lipoprotein metabolism, increasing HDL plasma concentrations and enhance the synthesis of Apo A-I and Apo AIV in preterm and term newborns (6). Likewise, dietary nucleotides seem to up-regulate the synthesis of long-chain polyunsaturated fatty acids in human neonates (2)(3)(4)(5) and affect the colonization of the intestine by enhancing the number of bifidobacteria and lowering the concentrations of Enterobacteria (7).…”

mentioning

confidence: 99%

Ribonucleic Acid Hydrolysis by Intestinal Explants of Neonatal Piglets

Rueda¹,

Gómez-León²,

Gil³

2002

Journal of Pediatric Gastroenterology and Nutrition

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Background: Healthy human adults are able to hydrolyze dietary nucleic acids and nucleotides in the gastrointestinal tract, thus facilitating absorption of the resulting nucleosides. However, little is directly known of the ability of infants to hydrolyze nucleic acids early in life. Methods: Purified RNA (50, 100, 250, and 500 mg/L) in a suitable medium was exposed to jejunal explants of weaning piglets to determine if enzymes expressed by the explants were sufficient to hydrolyze the nucleic acid. Aliquots from the media were taken at time intervals, from 0 to 6 hours, and assayed for ribonucleoside content by high-performance liquid chromatography. Results: The investigators found a significant increase of free ribonucleosides during the study period and for all RNA concentrations tested, thus suggesting that intestinal explants are able to hydrolyze RNA. The kinetics of nucleoside concentrations varied for each nucleoside. For example, inosine increased over the entire 6-hour period and adenosine increased for the first 2 hours, decreasing afterward. Conclusions: It is concluded that cells from the intestinal epithelium are capable of hydrolyzing RNA. These results suggest that RNA present in human milk is hydrolyzed in the intestinal tract of the breast-fed infant, thus providing an additional source of nucleosides. The results indicate that current supplementation of infant formulas with nucleotides should be reconsidered to take into account the contribution of RNA present in human milk to the pool of bioavailable nucleotides. JPGN 35:685-690, 2002.

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Nutritional Implications of Replacing Bovine Milk Fat With Vegetable Oil in Infant Formulas

Berger,

Fleith,

Crozier

2000

J. pediatr. gastroenterol. nutr.

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Dietary Nucleotides Enhance Plasma Lecithin Cholesterol Acyl Transferase Activity and Apolipoprotein A-IV Concentration in Preterm Newborn Infants

Cited by 33 publications

References 13 publications

Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers

Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers

Ribonucleic Acid Hydrolysis by Intestinal Explants of Neonatal Piglets

Nutritional Implications of Replacing Bovine Milk Fat With Vegetable Oil in Infant Formulas

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