Dietary nucleotide supplementation as an alternative to in-feed antibiotics in weaned piglets

Valini, G.A.C.; Duarte, Márcio de Souza; Calderano, Arele Arlindo; Teixeira, Lucas Medina; Rodrigues, Gustavo Amorim; Fernandes, Kenner Morais; Veroneze, Renata; Serão, Nick V. L.; Mantovani, Hilário Cuquetto; Rocha, Gabriel Cipriano

doi:10.1016/j.animal.2020.100021

Cited by 16 publications

(8 citation statements)

References 28 publications

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“…During the last decade, the administration of exogenous nucleotides as a feed additive to animal diets has gained the interest of researchers and producers. Nucleotide supplementation has been mainly implemented in monogastric animals and fish (Tie et al, 2019;Valini et al, 2021), but few research studies have reported effects of nucleotides on ruminants (Abbaslou et al, 2020;Górka et al, 2021). Thus, our trial focused on effects of oral administration of nucleotides on oxidative stress, immune challenge, and morphological changes of calves.…”

Section: Discussionmentioning

confidence: 99%

Oral administration of nucleotides in calves: Effects on oxidative status, immune response, and intestinal mucosa development

Dinardo

Maggiolino

Martinello

et al. 2022

Journal of Dairy Science

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The present work aimed to investigate the effects of nucleotide oral administration on oxidative stress biomarkers, immune responses, gut morphology, serum biochemical parameters, and growth performance in calves from birth to 25 d of life. A total of 40 male Holstein Friesian calves were randomly divided in 2 groups. All the calves were born and reared on the same commercial dairy farm. They were fed the same colostrum, milk replacer, and calf starter. Five grams/head of an additive were orally administered with a syringe directly in the mouth to calves of the nucleotide group (NG). The additive contained 74.12 g/100 g of nucleic acids from hydrolyzed yeast, and 75.38% was free nucleotide sodium salt. The other group represented the negative control (CG). At 25 d of life all of the calves were slaughtered. Calves supplemented with nucleotides had a higher final live weight and improved average daily gain, which was associated with better efficiency of nutrient use. Oral nucleotide administration did not affect IgG absorption efficiency; however, NG calves showed greater duodenum villi length and higher crypt depth compared with CG. Oral nucleotide administration increased the activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and the antioxidant capacity [ferric reducing antioxidant power and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) scavenging activity] both in plasma and in liver. An enhanced ability of cells to counter reactive oxygen species-and reactive nitrogen species-mediated damage was also observed in peripheral blood mononuclear cells from NG. The findings highlight the effectiveness of oral nucleotide administration, and potentially dietary supplementation of nucleotides, in boosting oxidative and immune status in newborn calves.

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Section: Discussionmentioning

confidence: 99%

Oral administration of nucleotides in calves: Effects on oxidative status, immune response, and intestinal mucosa development

Dinardo

Maggiolino

Martinello

et al. 2022

Journal of Dairy Science

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“…We observed an improvement in intestinal microvillus length that translates to an increase in the absorptive surface area of the enterocytes, thereby promoting growth performance. Furthermore, there were relatively high amounts of nucleotides and glutamine (3.5% and 4.88%, respectively) which can be used as building blocks to synthesize other compounds for cell proliferation [7,8]. The greater availability of this genomic material could support enterocyte growth and mucosal development in the duodenum of early-weaned piglets.…”

Section: Intestinal Morphologymentioning

confidence: 99%

“…It also represents a unique composition of nucleotides, microbial enzymes, mannan oligosaccharides (MOS), and β-glucans, which is not fully understood [5,6]. These components are important for RNA transcription, cell proliferation, intestinal homeostasis, and immunity that may positively affect growth performance of young animals [7,8]. According to Moehn et al [9], the incorporation of 9% yeast-derived protein led to a similar apparent and standardized ileal digestibility of amino acids as spray-dried plasma protein in young piglets.…”

Section: Introductionmentioning

confidence: 99%

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Boontiam

Bunchasak

Cho

et al. 2022

Animals

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Hydrolyzed yeast (HY)-derived protein from Saccharomyces cerevisiae has a high digestible protein content and nucleotides and is a sweetener immunostimulatory substance. This could be used in nursery diets to minimize diarrhea and improve the growth rate and gut health of early-weaned piglets. This research was conducted with the objective of examining the effect of the inclusion level of HY as a potential protein ingredient for early-weaned piglets. A total of 72 crossbred weaned piglets [(Landrace × Large White) × Duroc] were assigned to three dietary treatments in six replicates with four pigs per pen. Dietary treatments were: (i) control (CON), piglets weaned at 18 days; (ii) CON diet with 5% HY inclusion (HY5); and (iii) CON diet with 10% HY inclusion (HY10) in a corn–soybean meal-based basal diet. Increasing HY levels positively improved body weight, average daily gain, and average daily feed intake (linear effect, p < 0.05). Furthermore, there was a linear increase in N-retention, albumin, jejunal villus height, villus height-to-crypt depth ratio, immunoglobulin A, acetate and propionate production, and Lactobacillus spp. count proportional to the dose of the HY-supplemented diet (p < 0.05). It also observed a decrease in diarrheal rate, jejunal crypt depth, blood urea nitrogen, pro-inflammatory cytokines, branched amino acids, and E. coli corresponding to the HY-supplemented levels (p < 0.05). However, the changes in the apparent total tract digestibility (dry matter, crude ash, and crude fat), blood glucose, butyrate, and Salmonella spp. were unaffected by the dietary HY level. Therefore, the supplementation of HY in the diet for early-weaned pigs not only supported the growth rate and immune function but also activated the beneficial bacterial growth of the early-weaned piglets.

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“…Hence, improving the immunity of piglets may be a feasible method to against weaning stress (3,4). In the past decades, antibiotic, as a feed additive, has been employed in increasing daily gain and preventing disease of piglets or other economical animals (5,6). Likewise, it also plays an important role in bacterial diarrhea control (6).…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets

Chen

Mao

et al. 2022

Front. Vet. Sci.

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Dietary nucleotide supplementation as an alternative to in-feed antibiotics in weaned piglets

Cited by 16 publications

References 28 publications

Oral administration of nucleotides in calves: Effects on oxidative status, immune response, and intestinal mucosa development

Oral administration of nucleotides in calves: Effects on oxidative status, immune response, and intestinal mucosa development

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets

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