Dietary nitrate supplementation improves reaction time in type 2 diabetes: Development and application of a novel nitrate-depleted beetroot juice placebo

Abstract

We have developed an effective placebo beetroot juice for use in trials of supplementation of dietary nitrate. Two weeks supplementation of the diet with 7.5 mmol of nitrate per day caused a significant improvement in simple reaction time in individuals with T2DM.

Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release

“…Participants were randomized to: 1) Nitrate supplementation (beetroot juice 2x70ml/day, containing 12.0 mmoles nitrate) or 2) Placebo (nitratedepleted beetroot juice 2x70ml/day, containing 0.003 mmoles nitrate) for 7 days. Nitrate-depleted beetroot juice was prepared according to published methods (25). After a 7 day wash-out period, the second 7-day intervention was conducted.…”

Effects of dietary nitrate supplementation on the oxygen cost of exercise and walking performance in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled crossover trial

“…Other dosing regimens (0.068 [17], 0.064 [29], 0.086 [30] mmol/kg) similar to ours have been shown to be effective at this relative dose. Production of the placebo juice has been detailed previously [31], with the final product being indistinguishable in taste, color, texture, appearance, and odor from the nitrate-rich beetroot juice [32]. The final 70 ml of juice was consumed $3 h before the commencement of exercise on the morning of testing.…”

Challenges and Prospects for Building Resilient Disease Management Strategies and Tactics for the New York Table Beet Industry

“…These well-documented effects range from nutritional intervention to disease mitigation [5]. Among the most commonly reported physiological changes associated with beet consumption include improvements in cardiovascular health and sugar metabolism attributed to the rich source of dietary nitrate [6,7], the antioxidant and anti-inflammatory effects of betalains [8] and the potential to improve stamina in exercise [9]. Red table beets are also grown as the main source of betacyanins, the basis of natural coloring used to manufacture some food products [10].…”