Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction

Coggan, Andrew R.; Broadstreet, Seth R.; Mahmood, Kiran; Mikhalkova, Deana; Madigan, Michael J.; Bole, Indra; Park, Soo Hyung; Leibowitz, Joshua L.; Kadkhodayan, Ana; Thomas, Deepak P.; Thies, Dakkota; Peterson, Linda R.

doi:10.1016/j.cardfail.2017.09.004

Cited by 38 publications

(35 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Coggan et al . ) in heart failure patients. Therefore, increased NO 2 − exposure following NO 3 − supplementation might have important therapeutic application in patients with diseases of the cardiovascular system.…”

Section: Discussionmentioning

confidence: 98%

“…In addition to evoking positive effects in skeletal muscle, NO 3 − supplementation or administration of NO donors can improve Ca 2+ handling and contractile function in cardiomyocytes (Pironti et al 2016;Tocchetti et al 2007). There is also evidence to suggest that NO 3 − supplementation can improve skeletal muscle (Coggan et al 2015b) and cardiac (Zamani et al 2015) function, and exercise capacity (Zamani et al 2015;Coggan et al 2018) in heart failure patients. Therefore, increased NO 2 − exposure following NO 3 − supplementation might have important therapeutic application in patients with diseases of the cardiovascular system.…”

Section: Translational Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological

Bailey

Gandra

Jones

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

Key points Dietary nitrate supplementation increases plasma nitrite concentration, which provides an oxygen‐independent source of nitric oxide and can delay skeletal muscle fatigue. Nitrate supplementation has been shown to increase myofibre calcium release and force production in mouse skeletal muscle during contractions at a supra‐physiological oxygen tension, but it is unclear whether nitrite exposure can delay fatigue development and improve myofibre calcium handling at a near‐physiological oxygen tension. Single mouse muscle fibres acutely treated with nitrite had a lower force and cytosolic calcium concentration during single non‐fatiguing contractions at a near‐physiological oxygen tension. Nitrite treatment delayed fatigue development during repeated fatiguing isometric contractions at near‐physiological, but not at supra‐physiological, oxygen tension in combination with better maintenance of myofilament calcium sensitivity and sarcoplasmic reticulum calcium pumping. These findings improve understanding of the mechanisms by which increased skeletal muscle nitrite exposure might be ergogenic and imply that this is related to improved calcium handling. Abstract Dietary nitrate (NO3−) supplementation, which increases plasma nitrite (NO2−) concentration, has been reported to attenuate skeletal muscle fatigue development. Sarcoplasmic reticulum (SR) calcium (Ca2+) release is enhanced in isolated single skeletal muscle fibres following NO3− supplementation or NO2− incubation at a supra‐physiological PnormalO2 but it is unclear whether NO2− incubation can alter Ca2+ handling and fatigue development at a near‐physiological PnormalO2. We hypothesised that NO2− treatment would improve Ca2+ handling and delay fatigue at a physiological PnormalO2 in intact single mouse skeletal muscle fibres. Each muscle fibre was perfused with Tyrode solution pre‐equilibrated with either 20% (PnormalO2∼150 Torr) or 2% O2 (PnormalO2 = 15.6 Torr) in the absence and presence of 100 µM NaNO2. At supra‐physiological PnormalO2 (i.e. 20% O2), time to fatigue was lowered by 34% with NaNO2 (control: 257 ± 94 vs. NaNO2: 159 ± 46 s, Cohen's d = 1.63, P < 0.05), but extended by 21% with NaNO2 at 2% O2 (control: 308 ± 217 vs. NaNO2: 368 ± 242 s, d = 1.14, P < 0.01). During the fatiguing contraction protocol completed with NaNO2 at 2% O2, peak cytosolic Ca2+ concentration ([Ca2+]c) was not different (P > 0.05) but [Ca2+]c accumulation between contractions was lower, concomitant with a greater SR Ca2+ pumping rate (P < 0.05) compared to the control condition. These results demonstrate that increased exposure to NO2− blunts fatigue development at near‐physiological, but not at supra‐physiological, PnormalO2 through enhancing SR Ca2+ pumping rate in single skeletal muscle fibres. These findings extend our understanding of the mechanisms by which increased NO2− exposure can mitigate skeletal muscle fatigue development.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Translational Perspectivementioning

confidence: 99%

Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological

Bailey

Gandra

Jones

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Nutrition interventions to improve CRF in HFrEF patients have included micronutrient supplementation [76], amino acids (AA) [77][78][79][80][81], nutrition support supplementation [84], N-3 PUFA [82,83], and dietary nitrates [85,86].…”

Section: Heart Failurementioning

confidence: 99%

“…The authors suggested that this may have been related to inadequate dosing; however, a recent trial of inhaled nitrates without ET also failed to increase peak VO 2 in subjects with HFpEF [93]. Dietary nitrate supplementation has also resulted in mixed effects on CRF in small pilot trials of subjects with HFrEF without ET [85,86]. Currently, the INABLE-Training trial (NCT02713126) is combining higher dosing of oral nitrates with a cardiac rehabilitation (CR) program for 12 weeks in a double-blind, randomized placebo-controlled trial of patients with HFpEF on a primary outcome of peak VO 2 .…”

Section: Dietary Nitrate Supplementation In Hfpefmentioning

confidence: 99%

Lifestyle Interventions with a Focus on Nutritional Strategies to Increase Cardiorespiratory Fitness in Chronic Obstructive Pulmonary Disease, Heart Failure, Obesity, Sarcopenia, and Frailty

et al. 2019

View full text Add to dashboard Cite

Cardiorespiratory fitness (CRF) is an independent predictor for all-cause and disease-specific morbidity and mortality. CRF is a modifiable risk factor, and exercise training and increased physical activity, as well as targeted medical therapies, can improve CRF. Although nutrition is a modifiable risk factor for chronic noncommunicable diseases, little is known about the effect of dietary patterns and specific nutrients on modifying CRF. This review focuses specifically on trials that implemented dietary supplementation, modified dietary pattern, or enacted caloric restriction, with and without exercise training interventions, and subsequently measured the effect on peak oxygen consumption (VO 2 ) or surrogate measures of CRF and functional capacity. Populations selected for this review are those recognized to have a reduced CRF, such as chronic obstructive pulmonary disease, heart failure, obesity, sarcopenia, and frailty. We then summarize the state of existing knowledge and explore future directions of study in disease states recently recognized to have an abnormal CRF.

show abstract

“…However, no significant difference between BRJ or placebo was measured in a 50-contraction fatigue test or six-minute walk distance. A more recent study by the same researchers showed an increased peak measured VO2 (p < 0.05) and improved time to exhaustion (p < 0.05) without change in ventilation or efficiency during exercise in eight HFrEF patients consuming BRJ compared to placebo [41]. However, these results were not confirmed by Hirai et al who found no significant change in time to exhaustion or measured VO2 in 10 HFrEF patients treated with BRJ or placebo [42].…”

Section: Hypoxic Conditionsmentioning

confidence: 86%

Physiological Effects of Beetroot in Athletes and Patients

Olsson¹,

Al-Saadi²,

Oehler³

et al. 2019

Cureus

View full text Add to dashboard Cite

Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction

Cited by 38 publications

References 47 publications

Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological

Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological

Lifestyle Interventions with a Focus on Nutritional Strategies to Increase Cardiorespiratory Fitness in Chronic Obstructive Pulmonary Disease, Heart Failure, Obesity, Sarcopenia, and Frailty

Physiological Effects of Beetroot in Athletes and Patients

Contact Info

Product

Resources

About