Dietary nitrate and reductive polyphenols may potentiate the vascular benefit and alleviate the ulcerative risk of low-dose aspirin

McCarty, Mark F.

doi:10.1016/j.mehy.2012.11.025

Cited by 6 publications

(3 citation statements)

References 95 publications

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“…Nitric oxide and its donors reduce the severity of gastric damage in rats [8] , [25] . Furthermore NO is a strong gastroprotective agent and serves as a mediator of gastric mucosal defense and augments the resistance of the mucosa to injury [54] , enhances mucosal blood flow, and stimulates the production of gastric mucus and reduces infiltration of activated neutrophils [33] , [27] . Therefore the ameliorative effect of vanillin against gastric ulceration may be ascribed to the restoration of the depleted gastric mucus levels.…”

Section: Discussionmentioning

confidence: 99%

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

et al. 2016

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Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied in experimental gastric ulcer. Gastric secretion and acidity were studied in pylorus ligated rats. Ulcer index, levels of gastric mucus, malondialdehyde (MDA), myeloperoxidase activity (MPO), expression of nuclear factor kappa B (NF-κB) p65, and histopathological changes were determined in ethanol induced gastric ulcer. Pre treatment with vanillin significantly reduced gastric secretion (P < 0.001) and acidity (P < 0.0001) and gastric ulcer index scores (P < 0.001). and augmented the gastric mucosal defense. Vanillin significantly restored the depleted gastric wall mucus levels (P < 0.0001) induced by ethanol and also significantly attenuated ethanol induced inflammation and oxidative stress by the suppression of gastric MPO activity (P < 0.001), reducing the expression of NF-κB p65 and the increased MDA levels (P < 0.001). Vanillin was also effective in alleviating the damage to the histological architecture and the activation of mast cells induced by ethanol.Together the results of this study highlight the gastroprotective activity of vanillin in gastric ulcers of rats through multiple actions that include inhibition of gastric secretion and acidity, reduction of inflammation and oxidative stress, suppression of expression of NF-κB, and restoration of the histological architecture.

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Section: Discussionmentioning

confidence: 99%

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

et al. 2016

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“…Hence, and regarding this finding, dietary nitrate does not show carcinogenic activity and could be not harmful for human health. Furthermore, after HNDs and reductive polyphenols (such as epicatechin and quercetin), NO exerts gastroprotective effects by boosting blood flow and mucus production in the gastric mucosa, which could have the potential to amplify the vascular-protective benefits of low-dose aspirin, while diminishing its pro-ulcerative risk (39).…”

Section: Beneficial Health Effectsmentioning

confidence: 99%

Integrative Medicine for Cardiovascular Disease and Prevention

Aggarwal

Rao³

2017

Medical Clinics of North America

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“…Several pieces of evidence showed that NO can be used as a protective agent for gastric ulcer by promoting mucosal blood flow, stimulating gastric mucus secretion and reducing leukocyte infiltration ( Table 1 ). 21 22 23 …”

Section: Introductionmentioning

confidence: 99%

The role of nitric oxide in peptic ulcer: a narrative review

Liang

Deng

et al. 2021

Med Gas Res

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Peptic ulcer refers to the inflammatory response and necrotic lesions of the mucosa under the action of various pathogenic factors, which goes deeply into the mucosal muscle layer and often occurs to the gastrointestinal mucosa related to gastric acid secretion, among which the stomach and duodenum are the most common. The clinical manifestations include slow onset, prolonged course and weekly upper abdominal pain. Nitric oxide (NO) is an intracellular and intercellular signaling molecule that plays an important role in many physiological and pathological processes. Studies have found that a small amount of NO produced in vivo plays a role in many physiological homeostasis, such as regulating blood pressure, platelet aggregation, nitrogenization of hemoglobin, and regulating proliferation and differentiation of stem cells. However, under the action of some cytokines and oxidative stress, intracellular NO synthase will catalyze the synthesis of large amounts of NO and participate in the inflammatory response, causing beneficial or harmful effect on the body. Numerous basic studies have focused on the relationship between NO and peptic ulcer. The purpose of this review is to summarize the role of NO in peptic ulcer and its possible mechanism.

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Dietary nitrate and reductive polyphenols may potentiate the vascular benefit and alleviate the ulcerative risk of low-dose aspirin

Cited by 6 publications

References 95 publications

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

Integrative Medicine for Cardiovascular Disease and Prevention

The role of nitric oxide in peptic ulcer: a narrative review

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