Dietary n-3 polyunsaturated fatty acids or soy protein isolate did not attenuate disease progression in a female rat model of autosomal recessive polycystic kidney disease

Maditz, Kaitlin; Oldaker, Chris; Nanda, Nainika; Benedito, Vagner A.; Livengood, Ryan H.; Tou, Janet C.

doi:10.1016/j.nutres.2014.05.001

Cited by 10 publications

(14 citation statements)

References 33 publications

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“…12/15-HETE is a key player in pathogenesis of diabetic kidney disease [138]. Oxylipins can activate peroxisome proliferatoractivated receptors (PPARs), which are normally expressed in the kidneys and mediate cellular proliferation, inflammation and fibrosis [139].…”

Section: Oxylipins In Kidney Liver and Serummentioning

confidence: 99%

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Islam

Ravandi

Aukema

2018

The Journal of Nutritional Biochemistry

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High protein (HP) diets are often used as a means to reduce obesity, but their long-term effects remain unclear. In vitro studies suggest the involvement of a subset of oxylipins in the tissue response to HP diets. To examine the role of these bioactive lipids in vivo, normal adult male Sprague Dawley rats were provided isocaloric diets with LP (low protein, 8% protein by weight), NP (normal protein, 14%) or HP (50%) diets for 2 weeks, and targeted lipidomic analysis of oxylipins in kidney (cortex and medulla), liver and serum was performed by HPLC-MS/MS. The main group of oxylipins affected by the HP diet was the oxylipins derived from linoleic acid (LA), many of which were elevated in kidney (particularly the medulla) and liver, but reduced in serum of rats provided the HP compared to NP or LP diets. A smaller proportion of other n-6 fatty acid derived oxylipins were lower in kidney and higher in liver, and none were affected in serum, by HP feeding. Few n-3 oxylipins were affected by protein level. In liver only, the oxylipin product to substrate ratios of the soluble epoxide hydrolase enzyme were higher in LP fed rats. Differences between cortex and medulla oxylipins suggest relatively higher cortex activity of 5- and 8-lipoxygenase and cytochrome P450 hydroxylase, and higher medulla cyclooxygenase and 12- and 15-lipoxygenase activity. Further studies are needed to elucidate the physiological effects of the changes in these novel oxylipins in response to short-term dietary HP.

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Section: Oxylipins In Kidney Liver and Serummentioning

confidence: 99%

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Islam

Ravandi

Aukema

2018

The Journal of Nutritional Biochemistry

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“…(AIN-93G) diet [18] , while the HFD consisted of 52.5% standard diet, 20% sucrose, 15% lard, 9.5% casein, 1.7% calcium hydrogen phosphate, 1.1% cholesterol, and 0.2% sodium cholate. The composition of each diet is presented in [19] .…”

Section: Animal Treatment Protocolmentioning

confidence: 99%

Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats

Qiu¹,

Gao²,

Xiang³

et al. 2015

WJG

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“…In an orthologous model of human ARPKD, weanling female PCK rats fed 16% kcal fat as ALA/LNA soybean oil compared to LNA-rich corn oil for 12 weeks had higher (P < 0.001) renal tissue ALA and DHA content [29]. Renal tissue n-6 PUFA, ARA content was lower (P < 0.001) in rats fed soybean oil with soy protein isolate, but not when casein was the protein source.…”

Section: Authorsmentioning

confidence: 94%

“…There were no significant differences in renal EPA content among diet groups. EPA may have been mobilized from tissue stores for eicosanoid production due to renal damage resulting from greater cyst obstruction in rats fed fish oil blend diet [29]. The results suggested increasing renal tissue DHA content had adverse effects on PKD.…”

Section: Long-chain N-3 Pufas and Pkdmentioning

confidence: 97%

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Evaluating the therapeutic value of omega-3 polyunsaturated fatty acid supplementation on polycystic kidney disease and co-morbidities

Tou

Gigliotti

Maditz

2015

Current Opinion in Food Science

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Dietary n-3 polyunsaturated fatty acids or soy protein isolate did not attenuate disease progression in a female rat model of autosomal recessive polycystic kidney disease

Cited by 10 publications

References 33 publications

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats

Evaluating the therapeutic value of omega-3 polyunsaturated fatty acid supplementation on polycystic kidney disease and co-morbidities

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