Dietary myricetin assuages atrazine-mediated hypothalamic-pituitary–testicular axis dysfunction in rats

Ikeji, Cynthia  Nwamaka; Adedara, Isaac A.; Farombi, Ebenezer O.

doi:10.1007/s11356-022-23033-5

Cited by 5 publications

(2 citation statements)

References 73 publications

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“…This finding agrees with the poor sperm parameters including, membrane integrity, mitochondrial functionality, decrease acrosome integrity of sperms obtained in the mice, Calomys laucha after 21 days exposure of the animal to low dosages of ATZ (Saalfeld et al, 2018). In addition to the decrease in the levels of serum and intratesticular testosterone, following ATZ exposure in mice, we also detected notable decline in the levels of pituitary hormones in our recent study (Ikeji et al, 2023). This finding suggests that ATZ may induce dysfunction in hypothalamus orchestrating an adverse reaction in the secretion of gonadotropins and testosterone, thus perturbing the hypothalamic-pituitary-gonadal axis which plays pivotal role in male reproductive functions.…”

Section: Testicular Toxicity Of Atrazine In Experimental Modelssupporting

confidence: 92%

“…Similar observations were made with the rat pheochromocytoma (PC12) cell line ( Abarikwu et al, 2011b ) and confirmed the medicinal prospects of kolaviron in neuronal model of ATZ-induced apoptotic cell death. Myricetin, a flavonoid abundantly found in red wines and grapes, displayed protective effect on testicular injury caused by ATZ, increased levels of the pituitary hormones and recovered normal testosterone production and circulation in both serum and interstitial fluid ( Ikeji et al, 2023 ). Also, myricetin attenuated ATZ-induced diminution in antioxidant enzyme activities and markers of oxidative stress, including the histological aberrations in the epididymis, hypothalamus and testes of mice.…”

Section: Chemopreventive Intervention With Selected Antioxidantsmentioning

confidence: 99%

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Atrazine: cytotoxicity, oxidative stress, apoptosis, testicular effects and chemopreventive Interventions

Abarikwu,

Ezim,

Ikeji

et al. 2023

Front. Toxicol.

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Atrazine (ATZ) is an environmental pollutant that interferes with several aspects of mammalian cellular processes including germ cell development, immunological, reproductive and neurological functions. At the level of human exposure, ATZ reduces sperm count and contribute to infertility in men. ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. When in vitro experimental models are exposed to ATZ, they are faced with increased levels of reactive oxygen species (ROS), cytotoxicity and decreased growth rate at dosages that may vary with cell types. This results in differing cytotoxic responses that are influenced by the nature of target cells, assay types and concentrations of ATZ. However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems.

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Section: Testicular Toxicity Of Atrazine In Experimental Modelssupporting

confidence: 92%

Section: Chemopreventive Intervention With Selected Antioxidantsmentioning

confidence: 99%