Dietary mycotoxins binders: a strategy to reduce aflatoxin m1 residues and improve milk quality of lactating Beetal goats

Ullah, Haq Aman; Durrani, Aneela Zameer; Ijaz, Muhammad; Javeed, Aqeel; Sadique, Umer; Hassan, Zahoor Ul; Rahman, Altaf Ur; Shah, Maqsood; Khattak, Irfan

doi:10.1007/s00003-016-1046-0

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…For this reason, the use of many mycotoxin’s adsorbents has been aimed at removing mainly aflatoxin B1 from the gastrointestinal tract of farm animals. Indeed, numerous studies, the results of which are discussed in reviews [54,57,59], have demonstrated a fairly high efficiency of traditional aluminosilicate adsorbents or adsorbents from yeast cell walls to reduce the toxic effects of this mycotoxin and reduce the degree of transfer of its main metabolite, aflatoxin M1 to milk [32,90,91]. However, the effectiveness of these adsorbents with respect to more lipophilic mycotoxins, such as zearalenone (Log Pow = 3.6) or ochratoxin A (Log Pow = 4.7), was, as noted, significantly lower [54,56,57,58,59,60,61].…”

Section: Discussionmentioning

confidence: 99%

“…For example, the use of this adsorbent in a herd of Holstein-Frisian lactating cows led to a significant decrease in SCC and to an increase in milk yield in comparison with the control group for 40 days. At the same time, the rate and degree of decrease in SCC (−64%) in milk and the increase in milk yield (+11%) were higher [95] than those observed when other “traditional” adsorbents were used under similar conditions [65,90,91,96,97]. Despite this fact, final conclusions on the degree of effectiveness of the use of one or another adsorbent can be made only after conducting joint comparative tests of adsorbents under the same conditions and on the same feed base.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that SCC increases significantly with the use of toxic feed [65,90,91,95,96,97]. Most likely, this is due to the negative effect of toxic components of feed on the immune system of animals, whose function can be suppressed both by representatives of mycotoxins [66,82,83,84,100,101,102] and PAHs and POPs [103,104,105,106].…”

Section: Discussionmentioning

confidence: 99%

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Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

Sotnichenko

Pantsov

Shinkarev

et al. 2019

Toxins

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The steady growth of inflammatory diseases of the udder in dairy cattle forces us to look for the causes of this phenomenon in the context of growing chemical pollution of the environment and feeds. Within the framework of this concept, an analysis was made of the polarity level of the three toxic impurity groups, which are commonly present in dairy cattle feeds. These impurities are presented by mycotoxins, polyaromatic hydrocarbons (PAH) and persistent organic pollutants (POP). It has been determined that 46% of studied mycotoxins (n = 1500) and 100% of studied polyaromatic hydrocarbons (n = 45) and persistent organic pollutants (n = 55) are lipophilic compounds, prone to bioaccumulation. A comparative evaluation of the sorption capacity of four adsorbents of a different nature and polarity with respect to the simplest PAH, naphthalene and lipophilic estrogenic mycotoxin, zearalenone in vitro has been carried out. The highest efficiency in these experiments was demonstrated by the reversed-phase polyoctylated polysilicate hydrogel (POPSH). The use of POPSH in a herd of lactating cows significantly reduced the transfer of aldrin, dieldrin and heptachlor, typical POPs from the “dirty dozen”, to the milk. The relevance of protecting the main functional systems of animals from the damaging effects of lipophilic toxins from feeds using non-polar adsorbents, and the concept of evaluating the effectiveness of various feed adsorbents for dairy cattle by their influence on the somatic cell count in the collected milk are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

Sotnichenko

Pantsov

Shinkarev

et al. 2019

Toxins

View full text Add to dashboard Cite

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“…Binding mycotoxin is a physical method of stopping bacteria from degrading aflatoxins [31]. Activated carbon was used to eliminate patulin from naturally contaminated cider and aflatoxin from naturally infected milk, according to studies [32]. Mycotoxins levels were lowered using this method, but more research is needed to ensure food safety.…”

Section: Curative Strategies On Mycotoxins Detection and Controlmentioning

confidence: 99%

Mycotoxin’s Infections and Prevention Methods: State of the Art

Viviane¹,

Masabo²,

Habiyaremye³

et al. 2021

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“…Studies regarding the mycotoxin toxicity in swine are numerous, but solutions for the reduction of these adverse effects are few. For example, the most used method to counteract the negative impact of mycotoxins in animals is adding "mycotoxin binders" or "mycotoxin modifiers", which are very effective for aflatoxins [29] but have limited efficiency against other types of mycotoxins [30] and could bind also vitamins and trace elements [31], generating deficiencies. Adding different plant derived antioxidants in feed could be a better solution to diminish the deleterious effects of mycotoxins on animal health.…”

Section: Introductionmentioning

confidence: 99%

The Reduction of the Combined Effects of Aflatoxin and Ochratoxin A in Piglet Livers and Kidneys by Dietary Antioxidants

Popescu

Avramescu

Marin

et al. 2021

Toxins

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The purpose of this study was to investigate the combined effects of aflatoxin B1 and ochratoxin A on protein expression and catalytic activities of CYP1A2, CYP2E1, CYP3A29 and GSTA1 and the preventive effect of dietary byproduct antioxidants administration against these mycotoxin damage. Three experimental groups (E1, E2, E3) and one control group (C) of piglets after weaning (TOPIGS-40 hybrid) were fed with experimental diets for 30 days. A basal diet containing normal compound feed for starter piglets was used as a control treatment and free of mycotoxin. The experimental groups were fed as follows: E1—basal diet plus a mixture (1:1) of two byproducts (grapeseed and sea buckthorn meal), E2—the basal diet experimentally contaminated with mycotoxins (479 ppb OTA and 62ppb AFB1) and E3—basal diet containing 5% of the mixture (1:1) of grapeseed and sea buckthorn meal and contaminated with the mix of OTA and AFB1. After 4 weeks, the animals were slaughtered, and tissue samples were taken from liver and kidney in order to perform microsomal fraction isolation, followed by protein expression and enzymatic analyses. The protein expressions of CYP2E1 and CYP3A29 were up-regulated in an insignificant manner in liver, whereas in kidney, those of CYP1A2, CYP2E1 and CYP3A29 were down-regulated. The enzymatic activities of CYP1A2, CYP2E1 and CYP3A29 decreased in liver, in a significant manner, whereas in kidney, these increased significantly. The co-presence of the two mycotoxins and the mixture of grape seed and sea buckthorn meal generated a tendency to return to the control values, which suggest that grapeseed and sea buckthorn meal waste represent a promising source in counteracting the harmful effect of ochratoxin A and aflatoxin B.

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Dietary mycotoxins binders: a strategy to reduce aflatoxin m1 residues and improve milk quality of lactating Beetal goats

Cited by 10 publications

References 21 publications

Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

Mycotoxin’s Infections and Prevention Methods: State of the Art

The Reduction of the Combined Effects of Aflatoxin and Ochratoxin A in Piglet Livers and Kidneys by Dietary Antioxidants

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