Dietary Mushroom Intake and the Risk of Breast Cancer Based on Hormone Receptor Status

Abstract

Although many studies have documented the antitumor activities of mushrooms, the association between mushroom intake and breast cancer, defined by hormone receptor status, has received minimal empirical investigation. This study evaluated the association between mushroom intake and the risk of breast cancer according to hormone receptor status among Korean women. Mushroom intake and breast cancer risk were examined among 358 breast cancer patients and 360 cancer-free controls. Intake of mushrooms was assessed using a quantitative food frequency questionnaire. Greater mushroom intake was related to lower risk of breast cancers among premenopausal women (odds ratio [OR] = 0.35, 95% confidence interval [CI] = 0.13-0.91 for the highest vs. the lowest quartile intake). The association was stronger for premenopausal women with estrogen receptor (ER)+/progesterone receptor (PR) + tumors (OR = 0.30, 95% CI = 0.11-0.79 for the highest vs. the lowest quartile intake) than those with ER-/PRtumors. Our results suggest that high consumption of mushrooms might be related to lower risks for breast cancers among premenopausal women; this association may be more robust among women with hormone receptor positive tumors.

Diet and Cancer Risk in the Korean Population: A Meta-analysis

“…Various diets among the Korean population have been studied for the risk of gastric (10 studies) (Kim et al, 2002;Ko et al, 2013;Ko et al, 2009;Lee et al, 1995;Lee et al, 2003a;Nan et al, 2005;Park et al, 1998;Park et al, 2000;Wie et al, 2014;Zhang et al, 2009), colorectal (5 studies) (Ahn et al, 2006;Kim et al, 2011;Kim et al, 2003;Lee et al, 2005;Oh et al, 2005) and breast cancer (10 studies) (Cho et al, 2010;Do et al, 2007;Hong et al, 2008;Kim et al, 2009;Kim et al, 2008;Lee et al, 2007;Lee et al, 2004;Lee et al, 2003b;Shin et al, 2010;Yu et al, 2010) (Tables 1-3); the studied diet types have been mostly soy products, fruits, and vegetables. A limited number of studies were conducted for each diet.…”

Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by Dietary Supplement BreastDefend

“…3 Recent epidemiological studies from Asia demonstrated inverse correlation between mushroom intake and gastric, gastrointestinal, and breast cancer. [4][5][6][7] Moreover, different dietary phytochemicals have demonstrated cancer chemopreventive activities in tissue culture and animal studies. 8 For example, quercetin downregulated expression of Her-2, tyrosine kinase receptor, which is overexpressed in breast cancers.…”

The role of edible mushrooms in health: Evaluation of the evidence

“…An epidemiological study of women with histologically confirmed breast cancer has identified that daily intake and the average consumption frequency of mushrooms were inversely associated with breast cancer risk, and a strong inverse association was found in post-menopausal women, but not in premenopausal women (Hong, Kim, Nam, Kong, & Kim, 2008), which is in contrast to another epidemiological study that has suggested a decreased risk of breast cancer from mushroom consumption by pre-menopausal women (Shin et al, 2010). In this latter study, greater mushroom intake was related to lower risk of breast cancers among premenopausal women for the highest vs. the lowest quartile intake.…”