Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: A review

Martínez‐Montoro, José Ignacio; Martínez-Sánchez, María Antonia; Román, Andrés Balaguer; Gil-Martínez, José; Mesa-López, Maria José; Valenzuela, Juan Egea; Ruiz–Alcaraz, Antonio J.; Queipo-Ortuño, María Isabel; Ferrer, Miguel A.; Fernández‐García, José Carlos; Ramos‐Molina, Bruno

doi:10.1016/j.ijsu.2022.106751

Cited by 5 publications

(2 citation statements)

References 98 publications

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“…The extracts were then derivatized into fatty acid methyl esters (FAME), dried under a nitrogen stream and stored at -20°C until analysis. The FAME were analyzed with a GC-EI-MS QP-2020 NX (Shimadzu, Kyoto, Japan) [15].…”

Section: Gc-ms Analysis Of Fatty Acidsmentioning

confidence: 99%

The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma

Hellmann,

Zwara,

Czapiewska

et al. 2024

Preprint

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Background and objectives Over the years we observed changes in the metabolism of glucose, amino acids, fatty acids (FA) and nucleotides in cancer cells in order to maintain their viability and proliferate. Moreover, as the latest data show, cancer also forces a complete change in the behavior of other tissues. For instance, fat-filled adipocytes are often found in the vicinity of invasive solid human tumors. We investigated the effects of papillary thyroid carcinoma (PTC) on the lipid metabolism of healthy tissue distant from the tumor. Method Thyroid tissue was collected from female patients immediately after surgical removal of the entire thyroid gland. Blood samples were collected from PTC patients and healthy volunteers. Real-time PCR assays were performed to analyze the expression of lipogenic genes and a broad panel of FA was determined using the gas chromatography-mass spectrometry method. Results The concentration of lipids was higher in paratumor tissue than in healthy thyroid tissue (p=0.005). The lipogenic genes tested were significantly increased in paratumor tissue compared to healthy tissue, especially enzymes related to the synthesis of very long-chain saturated and polyunsaturated FAs (VLCSFAs and PUFAs, respectively) (p ˂0.001). The FA profile also showed increased levels of C22-C26, VLCSFAs and almost all PUFAs in paratumor tissue (p ˂0.05). Conclusion Our study suggests that a restructuring of lipid metabolism occurs in the adjacent healthy thyroid gland and that the metabolism of VLCSFAs and PUFAs is higher in the paratumor tissue than in the distant tissue of the healthy thyroid gland.

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Section: Gc-ms Analysis Of Fatty Acidsmentioning

confidence: 99%

The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma

Hellmann,

Zwara,

Czapiewska

et al. 2024

Preprint

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show abstract

“…The changes in intestinal microbiota may be related to the curative effect of colon cancer therapy [51,52]. Therefore, 16S ribosomal RNA (rRNA) sequencing analysis was performed to investigate the change of intestinal microbiota after PCM plus Laser-induced treatment.…”

Section: The Comprehensive Landscape Of Gut Microbiotamentioning

confidence: 99%

Bufotalin-loaded biomimetic prussian blue nanoparticles for colorectal cancer chemo-photothermal therapy via induce ferroptosis

Tian

Luo

et al. 2023

Preprint

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Background: As a ferroptosis-inducing platform, based on its release of iron and ferrous ions to induce production of reactive oxygen species (ROS), it has attracted extensive attention in cancer treatment. Since iron-based nanomaterials such as prussian blue (PB), can only produce limited ROS. Bufotalin (CS-5), a promising ferroptosis inducer, was introduced to improve the efficiency of ferroptosis. However, the clinical application of CS-5 was limited by cardiotoxicity and high renal clearance rate. Therefore, we constructed a biomimetic nanosystem (PB@CS-5@M) with satisfactory tumor enrichment ability and long blood circulation time for the treatment of colorectal cancer induced by ferroptosis. Results: In this work, the PB@CS-5@M has efficient loading of CS-5, which significantly reduces the cardiotoxicity of CS-5. After photothermal therapy, the high temperature caused by laser stimulation triggers the release of CS-5, iron and ferrous ions to kill colorectal cancer cells. Furthermore, the ability of CS-5 to significantly down-regulate the expression of GPX4 and HIF-1a, induce ROS production and damage mitochondria to induce ferroptosis in colorectal cancer was amplified. In addition, the down-regulation of HSP70 expression under laser stimulation effectively improved the chemosensitivity of HCT116 cells to CS-5. Conclusions: The chemotherapeutic effect of CS-5 combined with the photothermal effect of PB can effectively treat colon cancer by inducing ferroptosis.

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Genetically proxied intestinal microbiota and risk of bladder cancer

Zhang,

Yao,

Zhang

2024

International Journal of Surgery

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Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: A review

Cited by 5 publications

References 98 publications

The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma

The influence of cancer on the reprogramming of lipid metabolism in healthy thyroid tissues of patients with papillary thyroid carcinoma

Bufotalin-loaded biomimetic prussian blue nanoparticles for colorectal cancer chemo-photothermal therapy via induce ferroptosis

Genetically proxied intestinal microbiota and risk of bladder cancer

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