Dietary Micronutrient Intakes Are Associated with Markers of Inflammation but Not with Markers of Subclinical Atherosclerosis,

Abstract

Few studies have examined associations of dietary micronutrients with markers of inflammation and subclinical atherosclerosis. The present study investigated associations of heme iron, nonheme iron, zinc (Zn), magnesium (Mg), β-carotene, vitamin C, and vitamin E with C-reactive protein (CRP), IL-6, total homocysteine (tHcy), fibrinogen, coronary artery calcium, and common and internal carotid artery intima media thickness. Micronutrient intakes and markers of inflammation and subclinical atherosclerosis were studied in 5,181 participants from the Multi-Ethnic Study of Atherosclerosis who were aged 45-84 y and free of diabetes and cardiovascular disease. Models were adjusted for energy intake, demographics, lifestyle characteristics, and BMI. Dietary nonheme iron and Mg intakes were inversely associated with tHcy concentrations (mean tHcy: 9.11, 8.86, 8.74, 8.71, and 8.50 μmol/L, and 9.20, 9.00, 8.65, 8.76, and 8.33 μmol/L across increasing quintiles of nonheme iron and Mg, respectively; P-trend < 0.001 for both). However, dietary Zn and heme iron were positively associated with CRP [mean: 1.73, 1.75, 1.78, 1.88, and 1.96 mg/L across increasing quintiles of Zn and 1.72, 1.76, 1.83, 1.86, and 1.94 mg/L across increasing quintiles of heme iron (P-trend = 0.002 and 0.01, respectively). Other tested micronutrient-marker associations were not significant. In conclusion, of the 49 tested associations, only 7 were significant. Although this study does not provide strong support for associations between the micronutrients and markers of inflammation and subclinical atherosclerosis, the results are consistent with dietary guidelines that advocate for a balanced diet that includes a variety of plant foods containing Mg, Zn, and nonheme iron.

Composition of Dietary Macronutrient Intake Is Not Associated with Prevalence of Coronary Artery Calcification in Healthy Korean Adults

“…One prospective study in women showed that low carbohydrate intake and high saturated fat intake were associated with increased relative risk (RR) of CAC, but total energy, total fat and protein intake were not significantly related to the presence of CAC [24]. Several studies investigated relationships beetween dietary factors and other markers of subclinical atherosclerosis besides CAC [25,26]. Cross-sectional study reported that dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis [25].…”

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

“…Five studies included both men and women, and two studies consisted women only. Five studies used semi-quantitative food frequency questionnaires to collect dietary data, while other two studies used secondary dietary data from NHANES (1999-2000 and 1999-2002).In the original studies, dietary Mg intake was either categorized into three / four groups based on RDA levels (10,18) or divided into tertiles or quintiles (4,(13)(14)(15)17). Serum CRP was measured by using high sensitivity assay techniques (Table 1).…”

“…We extracted adjusted geometric means of CRP levels with 95% CIs as well as median Mg levels for each quintiles of Mg intake in cross-sectional studies (4,(13)(14)(15). In all the studies, data from fully adjusted models were used.…”

MexiB 6 AS A RESULT OF FORTIFICATION OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE WITH MAGNESIUM AND PYRIDOXINE: PROTEOME EFFECTS

“…Эти положения, вытекающие из фундаментальных исследований, подтверждаются результатами крупномас-штабных клинических исследований [25][26][27]. Например, в крупномасштабном исследовании, в котором участвовал 10 601 здоровый доброволец, показано, что высоким кон-центрациям пиридоксаль-5-фосфата в крови соответство-вали более низкие уровни гомоцистеина [27].…”

“…Например, в крупномасштабном исследовании, в котором участвовал 10 601 здоровый доброволец, показано, что высоким кон-центрациям пиридоксаль-5-фосфата в крови соответство-вали более низкие уровни гомоцистеина [27]. В крупномас-штабном исследовании атеросклероза (MESA), включав-шем 5181 участника в возрасте 45-84 лет, установлено, что потребление магния обратно пропорционально концентра-циям гомоцистеина (р<0,001) [26]. Таким образом, синер-гизм между ЭМГПС, пиридоксином и магнием весьма ва-жен для обезвреживания гомоцистеина -такое лекарствен-ное воздействие может существенно снизить риск развития инфаркта миокарда, ишемической болезни сердца, ишеми-ческого и тромботического инсульта.…”