Dietary micro-fibrillated cellulose improves growth, reduces diarrhea, modulates gut microbiota, and increases butyrate production in post-weaning piglets

Uddin, Md Karim; Mahmud, Md. Rayhan; Hasan, Shah; Peltoniemi, Olli; Oliviero, Claudio

doi:10.1038/s41598-023-33291-z

Cited by 9 publications

(4 citation statements)

References 73 publications

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“…However, butyric acid is easily oxidized and denatured, producing a pungent odor. A trace amount of butyric acid was produced after fermentation in this experiment, which had no significant impact on the aromatic smell of the fermented feed ( Słupecka-Ziemilska et al, 2022 ; Uddin et al, 2023 ). Biagi et al (2007) reported that adding a small amount of butyric acid as a feed additive to the feed can improve the microbial intestinal flora of piglets and immune system.…”

Section: Discussionmentioning

confidence: 82%

Efficient conversion of distillers grains as feed ingredient by synergy of probiotics and enzymes

Chen,

Deng,

Jiang

et al. 2024

Front. Microbiol.

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The direct feeding value of distillers grains is low due to the presence of higher cellulose, lignin and anti-nutritional factors such as mannan and xylan. In this study, complex enzymes and probiotic flora based on “probiotic enzyme synergy” technology were used to produce fermented distillers grains. The optimal substrate ratio, moisture content, fermentation time and temperature were determined. Subsequently, scale-up experiments were conducted to determine the performance of fermented feed. The results showed that multi-probiotic (Lactobacillus casei, Bacillus subtilis, Saccharomyces cerevisiae, and Aspergillus oryzae) cooperated with complex enzymes (glucanase, mannanase, xylanase) showed excellent fermentation effect, crude protein, trichloroacetic acid soluble protein and fat increased by 31.25, 36.68, and 49.11% respectively, while crude fiber, acidic fiber and neutral fiber decreased by 34.24, 26.91, and 33.20%, respectively. The anti-nutritional factors mannan and arabinoxylan were reduced by 26.96 and 40.87%, respectively. Lactic acid, acetic acid, and propionic acid in the fermented organic acids increased by 240.93, 76.77, and 89.47%, respectively. Butyric acid increased significantly from scratch, and the mycotoxin degradation effect was not significant. This study provides a potential approach for high-value utilization of distillers grains.

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Section: Discussionmentioning

confidence: 82%

Efficient conversion of distillers grains as feed ingredient by synergy of probiotics and enzymes

Chen,

Deng,

Jiang

et al. 2024

Front. Microbiol.

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“…In addition, we also found the genus Intestinibacter to be associated with a lower risk of GH. There have been relatively few previous studies on Intestinibacter , but observational study and animal model have both reported the role of Intestinibacter in producing butyrate [ 24 , 25 ], which is a short chain fatty acid (SCFA) metabolized by GM. Placental inflammation and angiogenic factors played the central role in affecting blood pressure in pregnancy, and macrophages are the key regulator [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

Wu,

Li,

Lin

et al. 2023

Aging

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Background: Recent studies have shown that gut microbiota (GM) is related to hypertensive disorders in pregnancy (HDP). However, the causal relationship needs to be treated with caution due to confounding factors and reverse causation. Methods: We obtained genetic variants from genome-wide association studies including GM (N = 18,340) in MiBioGen Consortium as well as HDP (7,686 cases/115,893 controls) and specific subtypes in FinnGen Consortium. Then, Inverse variance weighted, maximum likelihood, weighted median, MR-Egger, and MR.RAPS methods were applied to examine the causal association. Reverse Mendelian randomization (RMR) and multivariable MR were performed to confirm the causal direction and adjust the potential confounders, respectively. Furthermore, sensitivity analyses including Cochran’s Q statistics, MR-Egger intercept, MR-PRESSO global test, and the leave-one-out analysis were conducted to detect the potential heterogeneity and horizontal pleiotropy. Results: The present study found causalities between eight gut microbial genera and HDP. The HDP-associated gut microbial genera identified by MR analyses varied in different subtypes. Specifically, our study found causal associations of LachnospiraceaeUCG010, Olsenella, RuminococcaceaeUCG009 , Ruminococcus2 , Anaerotruncus , Bifidobacterium , and Intestinibacter with GH, of Eubacterium ( ruminantium group ), Eubacterium ( ventriosum group ), Methanobrevibacter , RuminococcaceaeUCG002 , and Tyzzerella3 with PE, and of Dorea and RuminococcaceaeUCG010 with eclampsia, respectively. Conclusions: This study first applied the MR approach to detect the causal relationships between GM and specific HDP subtypes. Our findings may promote the prevention and treatment of HDP targeted on GM and provide valuable insights to understand the mechanism of HDP in different subtypes from the perspective of GM.

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“…Limited previous studies have investigated the association between Intestinibacter and childhood obesity. However, both observational studies and animal models consistently emphasize the role of Intestinibacter in the production of butyrate, a metabolite generated through microbial fermentation ( 48 , 49 ). Butyrate increases fatty acid oxidation in the muscle and decreases lipolysis via the orphan G protein–coupled receptor 43 pathway in white adipose tissue ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization analyses support causal relationship between gut microbiota and childhood obesity

Li,

Gao,

Luo

et al. 2023

Front. Pediatr.

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BackgroundChildhood obesity (CO) is an increasing public health issue. Mounting evidence has shown that gut microbiota (GM) is closely related to CO. However, the causal association needs to be treated with caution due to confounding factors and reverse causation.MethodsData were obtained from the Microbiome Genome Consortium for GM as well as the Early Growth Genetics Consortium for childhood obesity and childhood body mass index (CBMI). Inverse variance weighted, maximum likelihood, weighted median, and MR.RAPS methods were applied to examine the causal association. Then replication dataset was used to validate the results and reverse Mendelian randomization analysis was performed to confirm the causal direction. Additionally, sensitivity analyses including Cochran's Q statistics, MR-Egger intercept, MR-PRESSO global test, and the leave-one-out analysis were conducted to detect the potential heterogeneity and horizontal pleiotropy.ResultsOur study found suggestive causal relationships between eight bacterial genera and the risk of childhood obesity (five for CO and four for CBMI). After validating the results in the replication dataset, we finally identified three childhood obesity-related GM including the genera Akkermansia, Intestinibacter, and Butyricimonas. Amongst these, the genus Akkermansia was both negatively associated with the risk of CO (OR = 0.574; 95% CI: 0.417, 0.789) and CBMI (β = −0.172; 95% CI: −0.306, −0.039).ConclusionsIn this study, we employed the MR approach to investigate the causal relationship between GM and CO, and discovered that the genus Akkermansia has a protective effect on both childhood obesity and BMI. Our findings may provide a potential strategy for preventing and intervening in CO, while also offering novel insights into the pathogenesis of CO from the perspective of GM.

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Dietary micro-fibrillated cellulose improves growth, reduces diarrhea, modulates gut microbiota, and increases butyrate production in post-weaning piglets

Cited by 9 publications

References 73 publications

Efficient conversion of distillers grains as feed ingredient by synergy of probiotics and enzymes

Efficient conversion of distillers grains as feed ingredient by synergy of probiotics and enzymes

Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

Mendelian randomization analyses support causal relationship between gut microbiota and childhood obesity

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