Dietary methyl donor deficiency during pregnancy in rats shapes learning and anxiety in offspring

Konycheva, Galina; Dziadek, Marie; Ferguson, Lynnette R.; Krägeloh, Christian U.; Coolen, Marcel W.; Davison, Michael; Breier, Bernhard H.

doi:10.1016/j.nutres.2011.09.015

Cited by 56 publications

(50 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-and/or postnatal protein restriction in rats increased open arm entries, time and distance in elevated plus maze test, suggesting decreased avoidance (less anxiety) and increased exploration (Reyes-Castro et al, 2011). In another study using the similar elevated plus maze test, growth restriction through the maternal deficiency of methyl donors, i.e., choline, folate and methionine, showed an increase in anxiety-related behaviors in rats (Konycheva et al, 2011). In mice, maternal protein restriction resulted in persistent alterations in dopamine circuitry and increases in dopamine-dependent behaviors (Vucetic et al, 2010).…”

Section: Discussionmentioning

confidence: 89%

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

et al. 2012

View full text Add to dashboard Cite

-To clarify the effect of systemic growth retardation on behavior, pregnant rats were fed a synthetic diet with either a normal (20% casein) or low (10% casein) protein concentration from gestational day 10 to postnatal day (PND) 21 at weaning. Offspring were examined for sensory and reflex functions, detailed clinical observations, manipulative test, grip strength, motor activity and water-filled multiple T-maze test. Lowering trend in the air righting reflex index during lactation period and a decrease in grip strength on PND 72 were observed in the low protein diet group showing suppression of systemic growth. However, they were simply the reflection of delayed systemic growth, because parameters on impaired reflex function, disturbance of motor function and paralysis were unaffected. On the other hand, low protein diet resulted in increased motor activity in female offspring. Thus, malnutrition due to maternal protein restriction may cause adolescent hyperactivity.

show abstract

Section: Discussionmentioning

confidence: 89%

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The effects of maternal methyl donor availability on fetal growth were inconsistent. In rats, maternal methyl donor deficiency during pregnancy leads to reduced birth weight [39], whereas in mice, perinatal choline supplementation did not affect the birth weight [40]. These divergent results may be interpreted by a number of attributes including animal species, physiological stage, methyl donor type as well as the level and the duration of methyl donor supplementation.…”

Section: Discussionmentioning

confidence: 94%

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions

Sun

et al. 2014

Eur J Nutr

View full text Add to dashboard Cite

show abstract

“…A seminal article by Waterland et al (2008) subsequently reported that methyl donor supplementation induces DNA hypermethylation during development and prevents transgenerational amplification of obesity in agouti viable yellow (Avy) mice. After that, many studies have analyzed the epigenetic effects of a diet deficient in methyl donors or with methyl donor supplementation during pregnancy in different metabolic diseases, including altered behavior in offspring (i.e, anxiety) through permanent changes in hippocampal DNA methylation (Konycheva et al, 2011). However, until now, few studies have associated perinatal methyl donors with long-term changes in body weight and metabolism.…”

Section: Methyl Donorsmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

253

161

View full text Add to dashboard Cite

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

show abstract

Dietary methyl donor deficiency during pregnancy in rats shapes learning and anxiety in offspring

Cited by 56 publications

References 81 publications

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Contact Info

Product

Resources

About