Dietary methionine restriction ameliorates the impairment of learning and memory function induced by obesity in mice

Xu, Yao; Yang, Yuhui; Sun, Jin; Zhang, Yuanyuan; Luo, Tingyu; Li, Bowen; Jiang, Yuge; Shi, Yonghui; Li, Guowei

doi:10.1039/c8fo01922c

Cited by 41 publications

(75 citation statements)

References 72 publications

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“…Methionine restriction in rodents reproduces the beneficial effects of total amino acid restriction, on body weight and composition, insulin sensitivity and sympathetically mediated energy expenditure. Compared to total amino acid restriction, methionine restriction can lead to either hyperphagia or transient hypophagia in diet induced obesity rodent models [87,88]. Methionine restriction improves glucose metabolism and insulin sensitivity in obese mice by a cross talk between the adipose tissue and skeletal muscle, involving an adipose-derived factor, the adiponectin.…”

Section: Sulfur Based Amino Acids As a Potential Therapy For Obesitymentioning

confidence: 99%

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Protein, amino acids and obesity treatment

Simonson

Boirie‌

Guillet

2020

Rev Endocr Metab Disord

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Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free massespecially muscle might be detrimental. This occurs because protein breakdown predominates over synthesis, thus administering anabolic dietary compounds like proteins might counter fat free mass loss while allowing for fat mass loss. Indeed, varying the quantity of proteins will decrease muscle anabolic response and increase hyperphagia in rodents fed a low protein diet; but it will favor lean mass maintenance and promote satiety, in certain age groups of humans fed a high protein diet. Beyond protein quantity, protein source is an important metabolic regulator: whey protein and plant based diets exercize favorable effects on the risk of developing obesity, body composition, metabolic parameters or fat free mass preservation of obese patients. Specific amino-acids like branched chain amino acids (BCAA), methionine, tryptophan and its metabolites, and glutamate can also positively influence parameters and complications of obesity especially in rodent models, with less studies translating this in humans. Tuning the quality and quantity of proteins or even specific amino-acids can thus be seen as a potential therapeutic intervention on the body composition, metabolic syndrome parameters and appetite regulation of obese patients. Since these effects vary across age groups and much of the data comes from murine models, long-term prospective studies modulating proteins and amino acids in the human diet are needed.

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Section: Sulfur Based Amino Acids As a Potential Therapy For Obesitymentioning

confidence: 99%

“…In DIO mice models, methionine restriction also improves lipid profiles and hepatosteatosis [ 56 , 88 , 90 , 93 , 94 ]. Methionine restriction reduced the lipogenesis/lipid catabolism ratio, improving lipid accumulation and thus liver function, in male C57BL/6 J mice fed a 21 week long HFD [ 56 ].…”

Section: Using Specific Amino Acids To Treat Obesitymentioning

confidence: 99%

Protein, amino acids and obesity treatment

Simonson

Boirie‌

Guillet

2020

Rev Endocr Metab Disord

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“…[26] MR also ameliorates learning and memory impairments and reduces oxidative stress in the rat brain. [27] Moreover, potential implications of the relationship between MR and the gut microbiome were suggested by the finding that restriction of sulfur-containing amino acids improved barrier function by markedly upregulating Claudins. [28] Fermentative bacteria and sulfate-reducing bacteria metabolize Met and other sulfurcontaining compounds, [29] and these organisms might produce similar effects in humans, because short-term changes in dietary sulfur were found to influence the relative abundance of intestinal sulfate-reducing bacteria.…”

Section: Introductionmentioning

confidence: 99%

Methionine Restriction Regulates Cognitive Function in High‐Fat Diet‐Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing‐ and Inflammation‐Related Microbes

Wang

Ren

Hui

et al. 2020

Molecular Nutrition Food Res

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Scope Methionine restriction (MR) is known to potently alleviate inflammation and improve gut microbiome in obese mice. The gut microbiome exhibits diurnal rhythmicity in composition and function, and this, in turn, drives oscillations in host metabolism. High‐fat diet (HFD) strongly altered microbiome diurnal rhythmicity, however, the role of microbiome diurnal rhythmicity in mediating the improvement effects of MR on obesity‐related metabolic disorders remains unclear. Methods and results 10‐week‐old male C57BL/6J mice are fed a low‐fat diet or HFD for 4 weeks, followed with a full diet (0.86% methionine, w/w) or a methionine‐restricted diet (0.17% methionine, w/w) for 8 weeks. Analyzing microbiome diurnal rhythmicity at six time points, the results show that HFD disrupts the cyclical fluctuations of the gut microbiome in mice. MR partially restores these cyclical fluctuations, which lead to time‐specifically enhance the abundance of short‐chain fatty acids producing bacteria, increases the acetate and butyric, and dampens the oscillation of inflammation‐related Desulfovibrionales and Staphylococcaceae over the course of 1 day. Notably, MR, which protects against systemic inflammation, influences brain function and synaptic plasticity. Conclusion MR could serve as a potential nutritional intervention for attenuating obesity‐induced cognitive impairments by balancing the circadian rhythm in microbiome‐gut‐brain homeostasis.

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“…(113) High-fat diet induced obese mice exhibit impaired learning and memory, accompanied by a reduction in H 2 S production in the hippocampus, cortex, and plasma. (114) Higher hippocampal inflammation was also observed. However, obese animals fed high-fat and low methionine diet for the same period, improved in all behavioural tasks, alongside decreased brain inflammation and normalization of H 2 S levels.…”

Section: Methionine Restriction and Cognitive Functionmentioning

confidence: 94%

“…However, obese animals fed high-fat and low methionine diet for the same period, improved in all behavioural tasks, alongside decreased brain inflammation and normalization of H 2 S levels. (114) Dietary alterations might alter the methionine cycle, producing chronically elevated levels of homocysteine. The increased plasma concentration of homocysteine has been linked with cognitive decline, dementia, and AD, (115) being shown to induce alterations in the hippocampal plasticity and a slow-onset reduction of synaptic transmission, what confirms its possible role in the pathology of neurodegenerative diseases.…”

Section: Methionine Restriction and Cognitive Functionmentioning

confidence: 99%

Effects of dietary restriction on metabolic and cognitive health

2020

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Life expectancy in most developed countries has been rising over the last century. In the UK alone, there are around 12 million people over 65 years old and centenarians have increased by 85% in the past 15 years. As a result of our ageing population, which is due mainly to improvements in medical treatments, public health, improved housing and lifestyle choices, there is an associated increase in prevalence of pathological conditions, such as metabolic disorders, type 2 diabetes (T2D), cardiovascular and neurodegenerative diseases, many types of cancer and others. Statistics suggest that nearly 54% of elderly people in the UK live with at least two chronic conditions, revealing the urgency for identifying interventions that can prevent and/or treat such disorders. Nonpharmacological, dietary interventions such as caloric restriction (CR) and methionine restriction (MR) have revealed promising outcomes in increasing longevity and preventing and/or reversing the development of ageing-associated disorders. In this review, we discuss the evidence and mechanisms that are involved in these processes. FGF21 and H 2 S are important molecules involved in the effects of CR and MR in the extension of life span. Their role is also associated with the prevention of metabolic and cognitive disorders, highlighting these interventions as promising modulators for improvement of health span.

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Dietary methionine restriction ameliorates the impairment of learning and memory function induced by obesity in mice

Abstract: Dietary methionine restriction improves impairment of learning and memory function induced by obesity, likely by increasing H2S production.

Cited by 41 publications

References 72 publications

Protein, amino acids and obesity treatment

Protein, amino acids and obesity treatment

Methionine Restriction Regulates Cognitive Function in High‐Fat Diet‐Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing‐ and Inflammation‐Related Microbes

Effects of dietary restriction on metabolic and cognitive health

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