Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China

Du, Shanshan; Wu, Xiaoyan; Han, Tianshu; Duan, Wei; Liu, Lei; Qi, Jiayue; Niu, Yucun; Na, Lixin; Sun, Changhao

doi:10.1007/s00125-018-4674-3

Cited by 41 publications

(30 citation statements)

References 46 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Does BA-dependent regulation of Mn homeostasis have any impact on cardiometabolic disease? Some researchers have reported that patients with type 2 diabetes have plasma or serum Mn at levels higher than controls, whereas others have reported the opposite (73)(74)(75)(76). Because Mn levels must be maintained within a small range (31,44), it makes sense that both deficiency and excess of Mn would lead to negative consequences.…”

Section: Discussionmentioning

confidence: 99%

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Ahmad

Higuchi

Bertaggia

et al. 2020

Journal of Biological Chemistry

View full text Add to dashboard Cite

Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out physicochemical and signaling functions. A major site of BA action is the terminal ileum, where enterocytes actively reuptake BAs and express high levels of BA-sensitive nuclear receptors. BA pool size and composition are affected by changes in metabolic health, and vice versa. One of several factors that differentiate BAs is the presence of a hydroxyl group on C12 of the steroid ring. 12α-hydroxylated BAs (12HBAs) are altered in multiple disease settings, but the consequences of 12HBA abundance are incompletely understood. We employed mouse primary ileum organoids to investigate the transcriptional effects of varying 12HBA abundance in BA pools. We identified Slc30a10 as one of the top genes differentially induced by BA pools with varying 12HBA abundance. SLC30A10 is a manganese (Mn) efflux transporter critical for whole-body manganese excretion. We found that BA pools, especially those low in 12HBAs, induce cellular manganese efflux, and that Slc30a10 induction by BA pools is driven primarily by lithocholic acid signaling via the vitamin D receptor. Administration of lithocholic acid or a vitamin D receptor agonist resulted in increased Slc30a10 expression in mouse ileum epithelia. These data demonstrate a previously unknown role for BAs in intestinal control of Mn homeostasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Ahmad

Higuchi

Bertaggia

et al. 2020

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Does BA-dependent regulation of Mn homeostasis have any impact on cardiometabolic disease? Some researchers have reported that patients with type-2 diabetes have plasma or serum Mn at levels higher than controls, while others have reported the opposite (73)(74)(75)(76). Because Mn levels must be maintained within a small range (31,44), it makes sense that both deficiency and excess of Mn would lead to negative consequences.…”

Section: Discussionmentioning

confidence: 99%

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Ahmad

Higuchi

Bertaggia

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Mn participates in various mechanisms involved in the genesis of DR, like the generation of ROS by having prooxidative properties and antioxidant mechanisms [127], and it could have a role in inflammation. In fact, the dietary intake of this micronutrient was inversely associated with the incidence of T2DM and was partially associated with lower OS measured by 8-hydroxydeoxyguanosine [128]; nevertheless, in preclinical studies, both deficient or excessive intake of Mn aggravated apoptosis by upregulating capase-3, caspase-8, and caspase-9 and inhibited Nrf2 signaling, while optimal intake protected against ROS, MDA, and protein carbonyl [129]. Mn may have a protective role against endothelial dysfunction by upregulating disulfide bond A-like protein (DsbA-L) and thus increasing adiponectin, which ultimately downregulate ICAM-1, a biomarker of endothelial dysfunction; nonetheless, its evaluation in retinal tissues is necessary [130].…”

Section: Nutraceuticalmentioning

confidence: 99%

Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation

Robles-Rivera

Castellanos-González

Olvera-Montaño

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a progressive disease induced by a sustained state of chronic hyperglycemia that can lead to several complications targeting highly metabolic cells. Diabetic retinopathy (DR) is a multifactorial microvascular complication of DM, with high prevalence, which can ultimately lead to visual impairment. The genesis of DR involves a complex variety of pathways such as oxidative stress, inflammation, apoptosis, neurodegeneration, angiogenesis, lipid peroxidation, and endoplasmic reticulum (ER) stress, each possessing potential therapeutic biomarkers. A specific treatment has yet to be developed for early stages of DR since no management is given other than glycemic control until the proliferative stage develops, offering a poor visual prognosis to the patient. In this narrative review article, we evaluate different dietary regimens, such as the Mediterranean diet, Dietary Pattern to Stop Hypertension (DASH) and their functional foods, and low-calorie diets (LCDs). Nutraceuticals have also been assessed in DR on account of their antioxidant, anti-inflammatory, and antiangiogenic properties, which may have an important impact on the physiopathology of DR. These nutraceuticals have shown to lower reactive oxygen species (ROS), important inflammatory factors, cytokines, and endothelial damage biomarkers either as monotherapies or combined therapies or concomitantly with established diabetes management or nonconventional adjuvant drugs like topical nonsteroidal anti-inflammatory drugs (NSAIDs).

show abstract

Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China

Cited by 41 publications

References 46 publications

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation

Contact Info

Product

Resources

About