Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α

Abstract

Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis. Results. There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55. Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) α, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31–5.36; P=0.003) and 1.98 (95% CI: 1.09–3.59; P=0.008). There was a direct negative effect of dietary magnesium intake on LTL (B=−0.002; P=0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005). Conclusions. Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.

Comparison of Chronic Wound Inpatients and Outpatients’ Diets and Meals Nutrient Content in Taabo Wound Management Unit, Côte d’Ivoire

“…Zinc deficiency is thought to be responsible for poor wound healing (Medicine 2003). As for magnesium the content ranged from 9.19 ppm to 18.6 ppm was lower than 300 ppm recommended daily as confirm Yu et al 2020 [31], its deficiency contributes to the aging of the skin, which can lead to a skin healing disorder, as supported by Colboc and Meaume 2018 [32]. As for calcium, it is essential for the vascular phase of healing leading to hemostasis, coagulation and fibrosis as mentioned by Démarchez 2014 [33], calcium deficiency can be the cause of hemorrhage.…”

Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian

“…In the present study, plasma magnesium level was independently and positively associated with telomere length even after adjusting for covariates. The majority of previous reports suggest that magnesium might have a protective effect on telomere attrition rate [ 32 , 33 , 34 ] whereas O’Callaghan et al [ 35 ] reported a negative association. It has also been reported that primary fibroblasts grown in a magnesium-deficient medium have increased telomere shortening and lose their replicative potential with accelerated expression of senescence-associated biomarkers [ 6 ].…”

Association of Dietary Magnesium Intake With Leukocyte Telomere Length in United States Middle-Aged and Elderly Adults

“…Mazidi et al ( 24 ) used data from NHAENS 1999–2001 and found mean (adjusted for sex, age, and race) dietary intakes of magnesium monotonically increased across TL quarters. Yu et al ( 32 ) conducted a cross-sectional study of 467 participants with a mean magnesium intake of 247.13 mg/day and found an inverse relationship between dietary magnesium and LTL. O’Callaghan et al ( 33 ) used data from 23 South Australians aged 65 years or older and found a negative association between telomere length and serum magnesium levels ( r = −0.61, P = 0.001, respectively).…”