Dietary magnesium intake alters age-related changes in rat adipose tissue cellularity

Devaux, Sylvie; Adrian, Markus; Laurant, Pascal; Berthelot, Alain; Quignard‐Boulangé, Annie

doi:10.1684/mrh.2016.0406

Cited by 10 publications

(3 citation statements)

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“…These findings are consistent with previous studies [37,39]. In addition to their effects on bone formation, Mg ions at optimal concentrations enhance the phenotype of chondrocytes [46], and magnesium deficiency elevates the numbers of adipocytes [47]. High concentrations of magnesium inhibit calcification of the extracellular matrix and protect articular cartilage via the Erk/autophagy pathway [27].…”

supporting

confidence: 91%

MicroRNA-16, via FGF2 Regulation of the ERK/MAPK Pathway, Is Involved in the Magnesium-Promoted Osteogenic Differentiation of Mesenchymal Stem Cells

Hua

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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microRNAs (miRNAs) participate in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, few reports have discussed the effect of miRNAs on the magnesium chloride (MgCl2)-induced promotion of osteogenic differentiation of BMSCs, a process involved in the healing of bone tissue. As determined in the present investigation, MgCl2 decreased miR-16 levels; increased levels of fibroblast growth factor 2 (FGF2), p-p38, and p-ERK; and promoted the osteogenic differentiation of BMSCs. Enhancement of miR-16 levels by an miR-16 mimic blocked these MgCl2-induced changes. Moreover, luciferase reporter assays confirmed that miR-16 binds to the 3′UTR region of FGF2 mRNA. Down-regulation of FGF2 blocked the MgCl2-induced increases of p-p38 and p-ERK and the promotion of the osteogenic differentiation of BMSCs. Furthermore, over-expression of miR-16 attenuated the MgCl2-induced overproduction of p-p38 and p-ERK1/2 and the high levels of osteogenic differentiation, effects that were reversed by elevated expression of FGF2. In summary, the present findings provide a mechanism by which miR-16 regulates MgCl2-induced promotion of osteogenic differentiation by targeting FGF2-mediated activation of the ERK/MAPK pathway.

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supporting

confidence: 91%

MicroRNA-16, via FGF2 Regulation of the ERK/MAPK Pathway, Is Involved in the Magnesium-Promoted Osteogenic Differentiation of Mesenchymal Stem Cells

Hua

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…However, clinical studies evaluating the effect of magnesium supplementation on the accumulation of adipose tissue are still lacking. In animal models, it has been observed that magnesium supplementation prevents the accumulation of adipose tissue associated with diet [ 22 ]. The mechanism that explains this association is not yet fully understood.…”

Section: Discussionmentioning

confidence: 99%

Higher dietary magnesium intake is associated with lower body mass index, waist circumference and serum glucose in Mexican adults

Castellanos-Gutiérrez

Sánchez‐Pimienta

Carriquiry

et al. 2018

Nutr J

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BackgroundObesity and diabetes mellitus (DM) are public health concerns in Mexico of top-level priority due to their high prevalence and their growth rate in recent decades. The accumulation of adipose tissue leads to an unbalanced release of pro-oxidant factors, which causes cellular damage and favors the development of comorbidities. Recent evidence suggests that oxidative stress also promotes the accumulation of adipose tissue and the development of insulin resistance. The objective of this study is to evaluate the association between usual intake of antioxidant nutrients, specifically vitamins A, C, E and magnesium with body mass index (BMI), waist circumference (WC) and serum glucose concentrations in a representative sample of Mexican adults.MethodologyWe analyzed data on diet, BMI, WC and serum glucose from the Mexican National Health and Nutrition Survey 2012. Analysis included 20- to 65-year-old adults without a known diagnosis of DM (n = 1573). Dietary information was obtained using the five-step multiple-pass method developed by the United States Department of Agriculture and adapted to the Mexican context. Nutrient usual intake distributions were estimated using the Iowa State University method, through the “Software for Intake Distribution Estimation” (PC-Side) v.1.02. Associations were analyzed using multivariate regression models.ResultsHigher dietary magnesium intake was associated with lower markers of adiposity, so that an increase in 10 mg per 1000 kcal/day of magnesium was associated with an average decrease in BMI of 0.72% (95% CI: -1.36, − 0.08) and 0.49 cm (95% CI: -0.92, − 0.07) of WC. Additionally, in women with normal glucose concentrations, an increase in magnesium intake was associated with an average decrease in serum glucose by 0.59% (95% CI: -1.08, − 0.09).ConclusionThe results suggest that magnesium intake is associated with lower BMI, WC and serum glucose in Mexican population. However, more studies are required to elucidate the nature of this association.Electronic supplementary materialThe online version of this article (10.1186/s12937-018-0422-2) contains supplementary material, which is available to authorized users.

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“…Mg2+ intake was decreased in 35% of French individuals with BMI>35 kg/m2 [16]The CARDIA 30-year study in over 5,000 subjects indicates that Mg2+ intake is inversely associated with obesity and C-reactive protein levels [17]. In addition to trials in animal models of induced obesity, Mg2 supplementation with magnesium + Inhibit fatty tissue buildup [18]. Also, human studies indicate an inverse association between Mg2+ magnesium intake and markers of obesity, such as BMI and waist circumference [19,20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum magnesium in obesity and overweight and normal weight

et al. 2022

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The current study aimed to estimate of Magnesium Mg+ in adults in Obesity, Overweight and Normal weight and compare them and the relationship of magnesium with Body mass index BMI ,waist circumference WC and lipid profile Materials and Methods: This study included 100 people (29) 29% males and (71) 71% females whose ages were over 20 years old. They were Also divided according to nutritional status into obese group, overweight group and normal weight. The information required for the samples was recorded and BMI was measured, WC , Mg level and lipid profile were measured .Results: The results showed a decrease in the magnesium level in the obese as well as in the overweight and it was normal in the normal weight. The level of magnesium decreased in women and was higher in men in all feeding conditions, and the BMI of women was higher than that of men. The results of this work showed that there is an inverse negative relationship between Mg and each of BMI, WC, TCHO, TG ,LDL while the positive correlation between Mg and HDL.Conclusion: In finally, magnesium deficiency can be considered one of the factors that lead to obesity, and diseases associated with obesity.

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Dietary magnesium intake alters age-related changes in rat adipose tissue cellularity

Cited by 10 publications

References 0 publications

MicroRNA-16, via FGF2 Regulation of the ERK/MAPK Pathway, Is Involved in the Magnesium-Promoted Osteogenic Differentiation of Mesenchymal Stem Cells

MicroRNA-16, via FGF2 Regulation of the ERK/MAPK Pathway, Is Involved in the Magnesium-Promoted Osteogenic Differentiation of Mesenchymal Stem Cells

Higher dietary magnesium intake is associated with lower body mass index, waist circumference and serum glucose in Mexican adults

Evaluation of serum magnesium in obesity and overweight and normal weight

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