Dietary Magnesium Deficiency Induces Heart Rhythm Changes, Impairs Glucose Tolerance, and Decreases Serum Cholesterol in Post Menopausal Women

Nielsen, Forrest H.; Milne, David B.; Klevay, Leslie M.; Gallagher, S K; Johnson, LuAnn K.

doi:10.1080/07315724.2007.10719593

Cited by 92 publications

(75 citation statements)

References 20 publications

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“…Magnesium deficiency is connected with the occurrence of many disorders, such as osteoporosis, hypertension, heart arrhythmia, impaired glucose tolerance, and serum cholesterol. [29][30][31] A reduced level of magnesium also increases oxidative stress and can reduce erythrocyte SOD concentrations. 30 Calcium (Ca) is involved in many metabolic processes.…”

Section: +mentioning

confidence: 99%

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Venous insufficiency: Differences in the content of trace elements. A preliminary report

Rusak¹,

Karuga-Kuźniewska²,

Wiatrak³

et al. 2018

Adv Clin Exp Med

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Background. Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Our results show that insufficient veins have different levels of some trace elements: magnesium, calcium, manganese, and silicon compared to control samples. This study could lead to a better understanding of the molecular causes of venous insufficiency and may help to develop better methods of treatment.

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Section: +mentioning

confidence: 99%

“…[29][30][31] A reduced level of magnesium also increases oxidative stress and can reduce erythrocyte SOD concentrations. 30 Calcium (Ca) is involved in many metabolic processes. It occurs in the human body mainly in the bones and teeth in the form of calcium hydroxyapatite.…”

Section: +mentioning

confidence: 99%

Venous insufficiency: Differences in the content of trace elements. A preliminary report

Rusak¹,

Karuga-Kuźniewska²,

Wiatrak³

et al. 2018

Adv Clin Exp Med

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“…Magnesium and its involvement in apo E/Aβ interactions determine cellular apo E expression [73] [74] and cholesterol metabolism [75]- [77] with relevance to Aβ oligomer formation and magnesium alterations determine Aβ flux from the brain to the liver [4]. Cholesterol has been shown to be directly involved in membrane APP/Aβ interactions and magnesium levels have been shown to determine cholesterol metabolism involved in the early stages of organ disease and amyloidosis [78]- [80].…”

Section: Magnesium Therapy Regulates Amyloid Beta Metabolism With Impmentioning

confidence: 99%

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

Martins¹

2016

Health

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In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer's disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions with the prevention of myocardial infarction and Type 3 diabetes. Magnesium deficiency and its effects on Sirt1 regulation have become important with magnesium deficiency associated with appetite dysregulation, senescence, glucose/nitric oxide dyshomeostasis, increased ceramide and toxic amyloid beta formation. Magnesium therapy activates the peripheral sink amyloid beta clearance pathway with the reversal of cell senescence associated with various chronic diseases such as cardiovascular disease, Type 3 diabetes and Alzheimer's disease.

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“…These are summarized in Micronutrient status may also be suboptimal in the acute phase of recovery from injury, but improve over time. 55 Almost all of the above listed micronutrients have been linked to glycemic and/or lipid profiles, [58][59][60][61][62][63][64][65][66][67][68][69][70][71] but a detailed exploration of these deficiencies and their association with CMS risks of dysglycemia and dyslipidemia exceeds the scope of this monograph. In addition, only a few of these deficiencies have consistently been reported to be prevalent in persons with SCI over the last 10 years.…”

Section: Micronutrients and Alcoholmentioning

confidence: 99%

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

Nash

Cowan

Kressler

2012

The Journal of Spinal Cord Medicine

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Component and coalesced health risks of the cardiometabolic syndrome (CMS) are commonly reported in persons with spinal cord injuries (SCIs). These CMS hazards are also co-morbid with physical deconditioning and elevated pro-atherogenic inflammatory cytokines, both of which are common after SCI and worsen the prognosis for all-cause cardiovascular disease. This article describes a systematic procedure for individualized CMS risk assessment after SCI, and emphasizes evidence-based and intuitioncentered countermeasures to disease. A unified approach will propose therapeutic lifestyle intervention as a routine plan for aggressive primary prevention in this risk-susceptible population. Customization of dietary and exercise plans then follow, identifying shortfalls in diet and activity patterns, and ways in which these healthy lifestyles can be more substantially embraced by both stakeholders with SCI and their health care providers. In cases where lifestyle intervention utilizing diet and exercise is unsuccessful in countering risks, available pharmacotherapies and a preferred therapeutic agent are proposed according to authoritative standards. The over-arching purpose of the monograph is to create an operational framework in which existing evidence-based approaches or heuristic modeling becomes best practice. In this way persons with SCI can lead more active and healthy lives.

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Dietary Magnesium Deficiency Induces Heart Rhythm Changes, Impairs Glucose Tolerance, and Decreases Serum Cholesterol in Post Menopausal Women

Cited by 92 publications

References 20 publications

Venous insufficiency: Differences in the content of trace elements. A preliminary report

Venous insufficiency: Differences in the content of trace elements. A preliminary report

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

Evidence-based and heuristic approaches for customization of care in cardiometabolic syndrome after spinal cord injury

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