Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

B, Pyndt Jørgensen; Winther, Gudrun; Kihl, Pernille; Nielsen, Dennis Sandris; Wegener, Gregers; Ak, Hansen; Sørensen, Dorte Bratbo

doi:10.1017/neu.2015.10

Cited by 50 publications

(33 citation statements)

References 18 publications

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“…Several previous studies have shown that calcium supplementation results in increased gut microbial diversity in mice [ 46 , 47 ]. Moreover, magnesium-deficient diets have been shown to adversely affect gut microbial composition, and to promote both anxiety- and depressive-like behaviour in mice [ 48 , 49 ]. However, there is little evidence to date on the effects of magnesium supplementation on gut microbial diversity.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

et al. 2018

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Accumulating evidence demonstrates that dietary supplementation with functional food ingredients play a role in systemic and brain health as well as in healthy ageing. Conversely, deficiencies in calcium and magnesium as a result of the increasing prevalence of a high fat/high sugar “Western diet” have been associated with health problems such as obesity, inflammatory bowel diseases, and cardiovascular diseases, as well as metabolic, immune, and psychiatric disorders. It is now recognized that modulating the diversity of gut microbiota, the population of intestinal bacteria, through dietary intervention can significantly impact upon gut health as well as systemic and brain health. In the current study, we show that supplementation with a seaweed and seawater-derived functional food ingredient rich in bioactive calcium and magnesium (0.1% supplementation) as well as 70 other trace elements, significantly enhanced the gut microbial diversity in adult male rats. Given the significant impact of gut microbiota on health, these results position this marine multi-mineral blend (MMB) as a promising digestive-health promoting functional food ingredient.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

et al. 2018

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“…The anxiolytic potential of Mg has been demonstrated in rodent models. Naturally and experimentally induced hypomagnesemia elevates anxiety states in mouse models [12,21,42,43]. Blood plasma and brain Mg levels are also significantly correlated with anxiety-related behavioral responses in rodents [44].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

2017

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Background: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. Methods: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken. Results: 18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome. Conclusions: Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.

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“…Interestingly, a significant correlation was found between the gut microbiota of the diet deficient in Mg and a decrease in hippocampal IL-6 levels, suggesting that this immunemodulation could be the mechanism by which diet induced changes in the gut microbiota composition alter behaviour [61]. A similar study found that a diet deficient in Mg decreased bacterial diversity and altered anxiety-like behaviour [62].…”

Section: Dietary Interventionsmentioning

confidence: 84%

Food for thought: The role of nutrition in the microbiota-gut–brain axis

Oriach¹,

Robertson²,

Stanton³

et al. 2016

Clinical Nutrition Experimental

192

107

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Recent research has provided strong evidence for the role of the commensal gut microbiota in brain function and behaviour. Many potential pathways are involved in this bidirectional communication between the gut microbiota and the brain such as immune mechanisms, the vagus nerve and microbial neurometabolite production. Dysbiosis of gut microbial function has been associated with behavioural and neurophysical deficits, therefore research focused on developing novel therapeutic strategies to treat psychiatric disorders by targeting the gut microbiota is rapidly growing. Numerous factors can influence the gut microbiota composition such as health status, mode of birth delivery and genetics, but diet is considered among the most crucial factors impacting on the human gut microbiota from infancy to old age. Thus, dietary interventions may have the potential to modulate psychiatric symptoms associated with gutebrain axis dysfunction. Further clinical and in vivo studies are needed to better understand the mechanisms underlying the link between nutrition, gut microbiota and control of behaviour and mental health.

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Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

Abstract: Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

Cited by 50 publications

References 18 publications

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

Food for thought: The role of nutrition in the microbiota-gut–brain axis

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