Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats

Goda, Yuki; Yamanaka, Daisuke; Nishi, Hisao; Masuda, Masato; Kamei, Hiroyasu; Kumano, Mikako; Ito, Koichi; Katsumata, Masaya; Yamanouchi, Keitaro; Kataoka, Naoyuki; Hakuno, Fumihiko; Takahashi, Shinichiro

doi:10.1016/j.jbc.2021.101179

Cited by 10 publications

(8 citation statements)

References 31 publications

(28 reference statements)

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“…It is worth mentioning that, unlike the decrease in levels seen with the majority of amino acids, histidine and serine increased by about 50 % and threonine by 2·5-fold with the deficient diet. The increase in threonine levels (and at a lower extent in histidine and serine) in lysine deficiency was previously reported in the literature ( 53 – 57 ) and could be explained by a hindered utilisation and/or oxidation of these amino acids.…”

Section: Discussionsupporting

confidence: 65%

Low-quality protein modulates inflammatory markers and the response to lipopolysaccharide insult: the case of lysine

et al. 2023

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The relationship between non-communicable diseases (NCDs) and eating behaviour has long been attributed to a surplus of food and energy. However, the increase in the prevalence of NCDs and their underlying low-grade inflammatory milieu among people of low socioeconomic status (SES) has highlighted the existence of a confounding factor. In this work, we aim to study the effect of lysine deficiency on some inflammatory markers in the absence or presence of an inflammatory insult [lipopolysaccharide (LPS)]. For this purpose, thirty-two five-week-old male Sprague Dawley rats were randomly distributed into four groups: 1) control diet, 2) control diet+LPS, 3) lysine-deficient diet, and 4) lysine-deficient diet+LPS. Groups were only allowed their experimental diets for four weeks, during which LPS (50 µg/kg) or saline injections were administered intraperitoneally three times per week. The study showed that lysine deficiency blunted growth and body compartments development, decreased albumin production and elevated liver c-reactive protein (CRP) expression, independently of interleukins 6 and 1β, the main precursors of CRP. Also, the insufficient levels of lysine in the diet increased hyperactivity and triggered an anxiety-like behaviour, exacerbated with LPS. This work presents evidence that various physiological changes are associated with the absence of a sufficient amount of lysine in the diet and can potentially increase the risk factor for diseases. Thus, the increment in NCDs among the low SES populations, who heavily rely on cereals as a main source of protein, can be, at least partially, blamed on low lysine availability in diets.

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Section: Discussionsupporting

confidence: 65%

Low-quality protein modulates inflammatory markers and the response to lipopolysaccharide insult: the case of lysine

et al. 2023

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“…Several studies have previously evaluated the potential effects of lysine on the regulation of lipid metabolism in animals. Goda et al [ 9 ] reported that triglycerides accumulate more in the muscle of rats fed with dietary lysine restriction. Katsuma et al [ 20 ] conveyed that a lysine-deficient diet can increase the lipid content in the skeletal muscle of pigs.…”

Section: Resultsmentioning

confidence: 99%

“…Lysine is a promising amino acid. Although reports are inconsistent, amino acids are reported to induce lipid accumulation in vivo and in vitro [ 9 , 10 ]. The mechanisms involved in enhancing adipocyte differentiation through decreasing level of lysine are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Low lysine stimulates adipogenesis through ZFP423 upregulation in bovine stromal vascular cells

Cruz¹,

Pacunla²,

Hwang³

2022

J Anim Sci Technol

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“…Besides the abnormal levels of D-homocysteine, the L-aspartic acid, and L-homoserine indicate a disordered cysteine and methionine metabolism, which plays a role in vascular inflammation, liver disease, and chronic renal failure [ 37 ]. Additionally, an elevated L-threonine level is associated with an abnormal muscular lipid accumulation [ 38 ]. Here, the LRA intake mitigated the impacts of the DG on these metabolites and may reduce the risk of age-related hepatic, renal, cardiovascular, and cerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Dietary Lycium ruthenicum Murr. Anthocyanins Intake Alleviated Oxidative Stress-Mediated Aging-Related Liver Injury and Abnormal Amino Acid Metabolism

Chen

Wang

2022

Foods

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In recent years, the relationship between Lycium ruthenicum Murr. anthocyanins (LRA) and health has attracted increasing attention. The purpose of this study is to investigate the anti-aging effect and mechanism of LRA through a D-galactose (DG)-induced aging rat model. Our results showed that the long-term intake of LRA, for 8 weeks, improved motor function, reduced serum aging markers, promoted the endogenous antioxidant system, and suppressed the serum inflammatory cytokines in aging rats. Besides, the LRA treatment alleviated DG-induced liver injuries by relieving the inflammation and inhibiting Fas/FasL-mediated cell death. More importantly, the abnormal serum metabolome profiles of the aging rats were restored by the LRA, relating to 38 metabolites and 44 pathways. Specifically, the LRA significantly affected the amino acid and protein-related metabolic pathways by regulating the levels of L-threonine, L-aspartic acid, glycine, L-histidine, D-homocysteine, L-homocitrulline, L-homoserine, guanidineacetic acid, and kynurenine. These results have important implications for the development of LRA as an anti-aging and liver-protective ingredient.

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Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats

Abstract: Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats,

Cited by 10 publications

References 31 publications

Low-quality protein modulates inflammatory markers and the response to lipopolysaccharide insult: the case of lysine

Low-quality protein modulates inflammatory markers and the response to lipopolysaccharide insult: the case of lysine

Low lysine stimulates adipogenesis through ZFP423 upregulation in bovine stromal vascular cells

Long-Term Dietary Lycium ruthenicum Murr. Anthocyanins Intake Alleviated Oxidative Stress-Mediated Aging-Related Liver Injury and Abnormal Amino Acid Metabolism

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