Dietary long-chain n−3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products

Niu, Kaijun; Hozawa, Atsushi; Kuriyama, Shinichi; Ohmori-Matsuda, Kaori; Shimazu, Taichi; Nakaya, Naoki; Fujita, Kazuki; Tsuji, Ichiro; Nagatomi, Ryoichi

doi:10.1093/ajcn/84.1.223

Cited by 89 publications

(59 citation statements)

References 35 publications

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“…Whilst there are no published LC n-3 PUFA intakes in Japanese children, Japanese adults 12 certainly consume much higher intakes of LC n-3 PUFA consuming at least 1g per day [15,16].…”

Section: Discussionmentioning

confidence: 99%

Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health

Meyer

Kolanu

2011

Nutrition

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“…Whilst there are no published LC n-3 PUFA intakes in Japanese children, Japanese adults 12 certainly consume much higher intakes of LC n-3 PUFA consuming at least 1g per day [15,16].…”

Section: Discussionmentioning

confidence: 99%

Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health

Meyer

Kolanu

2011

Nutrition

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“…Only 3 studies were based on populations with a broad range of EPA and DHA intakes (12,13,19), and none examined whether associations were nonlinear. FIGURE 1.…”

Section: Discussionmentioning

confidence: 99%

“…From 4 communities, we selected a random sample of 84 participants balanced across age strata (14)(15)(16)(17)(18)(19), and .50 y). The remaining 3 communities had ,84 participants; thus, all participants were included in these analyses.…”

Section: Study Samplementioning

confidence: 99%

“…Only 3 published observational studies were based on populations with chronic, high intakes of EPA and DHA (12,13,19); however, none reached intakes as high as those of Yup'ik Eskimos and none examined whether associations remain constant or are nonlinear across a broad range of intakes. Because of their traditional diet, which is based largely on fish and other marine foods (20), Yup'ik Eskimos have a mean intake of EPA and DHA that is .20 times the current mean intake of the general US population (3.7 compared with 0.14 g/d in men and 2.4 compared with 0.09 g/d in women) (21).…”

Section: Introductionmentioning

confidence: 99%

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Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among Yup’ik Eskimos

Makhoul¹,

Kristal²,

Gulati³

et al. 2010

The American Journal of Clinical Nutrition

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Background: Few studies have examined the associations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with biomarkers of chronic disease risk in populations with high intakes. Objective: We examined the associations of red blood cell (RBC) EPA and DHA, as percentages of total fatty acids, with biomarkers of chronic disease risk across a wide range of EPA and DHA intakes. Design: In a cross-sectional study of 357 Yup'ik Eskimos, generalized additive models were used to plot covariate-adjusted associations of EPA and DHA with chronic disease biomarkers. Linear regression models were used to test for the statistical significance of these associations. Results: Means (5th-95th percentiles) for RBC EPA and DHA were 2.8% (0.5-5.9%) and 6.8% (3.3-9.0%), respectively. Associations of EPA and DHA were inverse and linear for triglycerides (b 6 SE = 20.10 6 0.01 and 20.05 6 0.01, respectively) and positive and linear for HDL cholesterol (b 6 SE = 2.0 6 0.5 and 0.9 6 0.6, respectively) and apolipoprotein A-I (b 6 SE = 2.6 6 0.8 and 1.7 6 0.8, respectively). Positive linear associations of DHA with LDL and total cholesterol (b 6 SE = 7.5 6 1.4 and 6.80 6 1.57, respectively) were observed; for EPA, these associations were nonlinear and restricted to concentrations ',5% of total fatty acids. Associations of EPA and DHA with C-reactive protein were inverse and nonlinear: for EPA, the association appeared stronger at concentrations '.3% of total fatty acids; for DHA, it was observed only at concentrations '.7% of total fatty acids. Conclusion: Increasing EPA and DHA intakes to amounts well above those consumed by the general US population may have strong beneficial effects on chronic disease risk.Am J Clin Nutr 2010;91:777-85.

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“…The Tsurugaya project was a comprehensive geriatric assessment, which included medical status, physical function and cognitive function, performed in 2002 and 2003 [10][11][12][13][14][15] . In this study, we used the data for 2003 because baseline disability status as assessed by long-term care insurance (LTCI) certification was available.…”

Section: Study Participantsmentioning

confidence: 99%

Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project

Nitta

Hozawa

Kuriyama

et al. 2010

JAT

Self Cite

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Aim:The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26).Although the risk was attenuated (HR 1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.

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Dietary long-chain n−3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products

Cited by 89 publications

References 35 publications

Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health

Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health

Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among Yup’ik Eskimos

Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project

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