Dietary lipids and endometrial cancer: the current epidemiologic evidence

Bandera, Elisa V.; Kushi, Lawrence H.; Moore, Dirk F.; Gifkins, Dina; McCullough, Marjorie L.

doi:10.1007/s10552-007-9021-9

Cited by 36 publications

(48 citation statements)

References 47 publications

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“…The literature with respect to calcium and endometrial carcinogenesis is limited. In a rodent model, calcium reduces fat-induced cell proliferation by maintaining intracellular calcium concentrations (Jacobson et al, 1989) and greater fat intakes has been related to endometrial cancer risk (Bandera et al, 2007b). Calcium has been inversely associated with risk of breast cancer, another hormone-dependent cancer (Mccullough et al, 2005;Shin et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

McCullough¹,

Bandera²,

Moore³

et al. 2008

Preventive Medicine

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Objective-In response to a recent ecologic study of UV exposure and endometrial cancer incidence, we present the epidemiologic evidence on the relation between intake of vitamin D and its metabolically related nutrient, calcium, and the occurrence of endometrial cancer.Methods-We conducted a systematic literature review and meta-analysis of vitamin D and calcium in relation to endometrial cancer, including peer-reviewed manuscripts published up to May 2007. Random and fixed effects summary estimates were computed.Results-Pooled analyses of the three case-control studies of dietary vitamin D and endometrial cancer uncovered heterogeneous results that were not significant in random or fixed effects analyses. Cut-points for the highest vitamin D intakes ranged from >244 to >476 IU/day. Qualitatively similar findings were observed for dietary calcium. Only two studies provided estimates for calcium supplements (random effects OR=0.62, 95% CI 0.39-0.99; fixed effects OR=0.62, 95% CI 0.42-0.93, for top vs bottom category, p for heterogeneity=0.25).Conclusions-The limited epidemiological evidence suggests no relation between endometrial cancer in the ranges of dietary vitamin D examined, and suggests a possible inverse association for calcium from supplements. Prospective studies, ideally including plasma 25(OH) D to estimate vitamin D input from diet and sun exposure, are needed to further explore these hypotheses.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

McCullough¹,

Bandera²,

Moore³

et al. 2008

Preventive Medicine

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“…In the 2007 WCRF report, only 1 cohort study was cited [279] (LOE IIa) which examined the association between SFA intake and endometrial cancer. However, no risk association was found [257] (LOE IIa).…”

Section: Quantity and Quality Of Dietary Fat And Fatty Acid Intakementioning

confidence: 99%

“…The SLR for the WCRF report cited 1 cohort study, which showed no risk association [279] (LOE IIa). In the updated version of the WCRF report [261] (LOE IIa), MUFA were not covered for this carcinoma.…”

Section: Quantity and Quality Of Dietary Fat And Fatty Acid Intakementioning

confidence: 99%

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Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Wolfram

Bechthold²,

Boeing

et al. 2015

Ann Nutr Metab

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As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification of fat and/or fatty acid intake could have a preventive potential. The aim of the guideline of the German Nutrition Society (DGE) was to systematically evaluate the evidence for the prevention of the widespread diseases obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease (CHD), stroke, and cancer through the intake of fat or fatty acids. The main results can be summarized as follows: it was concluded with convincing evidence that a reduced intake of total and saturated fat as well as a larger intake of polyunsaturated fatty acids (PUFA) at the expense of saturated fatty acids (SFA) reduces the concentration of total and low-density lipoprotein cholesterol in plasma. Furthermore, there is convincing evidence that a high intake of trans fatty acids increases risk of dyslipoproteinaemia and that a high intake of long-chain polyunsaturated n-3 fatty acids reduces the triglyceride concentration in plasma. A high fat intake increases the risk of obesity with probable evidence when total energy intake is not controlled for (ad libitum diet). When energy intake is controlled for, there is probable evidence for no association between fat intake and risk of obesity. A larger intake of PUFA at the expense of SFA reduces risk of CHD with probable evidence. Furthermore, there is probable evidence that a high intake of long-chain polyunsaturated n-3 fatty acids reduces risk of hypertension and CHD. With probable evidence, a high trans fatty acid intake increases risk of CHD. The practical consequences for current dietary recommendations are described at the end of this article.

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“…The association between dietary cholesterol and EC has been assessed in nine previous case-control studies (20,(22)(23)(24)(25)28,31,32,34) with mixed results: three found statistically significant increased risks (20,24,32) , but the remaining six found non-significant reduced risks (23,25) , no association (34) or non-significant increased risks (22,28,31) . A pooled analysis of six of these studies reported a non-statistically significant increased risk of 35-39 % with higher cholesterol intake (29) . Studies of serum cholesterol have shown similar mixed results (35)(36)(37)(38)(39)(40)(41) .…”

Section: Discussionmentioning

confidence: 99%

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

Biel

Csizmadi

Cook

et al. 2011

Public Health Nutr.

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Objective: Intake of nutrients may influence the risk of endometrial cancer (EC). We aimed to estimate the association of intake of individual nutrients from food and from food plus supplements with EC occurrence. Design: A population-based case-control study conducted in Canada (2002Canada ( -2006. Setting: Nutrient intakes from food and supplements were assessed using an FFQ. Logistic regression was used to estimate EC risk within quartile levels of nutrient intakes. Subjects: Incident EC cases (n 506) were identified from the Alberta Cancer Registry, and population controls were frequency-and age-matched to cases (n 981). Results: There existed little evidence of an association with EC for the majority of macronutrients and micronutrients examined. We observed a statistically significant increased risk associated with the highest, compared with the lowest, quartile of intake of dietary cholesterol (multivariable-adjusted OR 5 1?51, 95 % CI 1?08, 2?11; P for trend 5 0?02). Age-adjusted risk at the highest level of intake was significantly reduced for Ca from food sources (OR 5 0?73, 95 % CI 0?54, 0?99) but was attenuated in the multivariable model (OR 5 0?82, 95 % CI 0?59, 1?13). When intake from supplements was included in Ca intake, risk was significantly reduced by 28 % with higher Ca (multivariable-adjusted OR 5 0?72, 95 % CI 0?51, 0?99, P for trend 5 0?04). We also observed unexpected increased risks at limited levels of intakes of dietary soluble fibre, vitamin C, thiamin, vitamin B 6 and lutein/zeaxanthin, with no evidence for linear trend. Conclusions: The results of our study suggest a positive association between dietary cholesterol and EC risk and an inverse association with Ca intake from food sources and from food plus supplements.

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Dietary lipids and endometrial cancer: the current epidemiologic evidence

Abstract: Background: Because dietary fat has been postulated to affect obesity and estrogen levels, two important risk factors for endometrial cancer, its association with this disease has received some attention. We summarize here the current evidence for several dietary lipids.

Cited by 36 publications

References 47 publications

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

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