Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice

DeCoffe, Daniella; Quin, Candice; Gill, S K; Tasnim, Nishat; Brown, Kirsty; Godovannyi, Artem; Dai, Chunping; Abulizi, Nijiati; Chan, Yee Kwan; Ghosh, Sanjoy; Gibson, Deanna L.

doi:10.1093/infdis/jiw084

Cited by 34 publications

(45 citation statements)

References 44 publications

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“…Beneficial effects of UF and olive oil were demonstrated in an acute DSS model of colitis and in mice with C. rodentium induced colitis. Disease amelioration included alleviation of oxidative stress, reduction of pro-inflammatory proteins and increased levels of intestinal alkaline phosphatase, which can de-phosphorylate bacterial LPS ( 161 – 163 ). In line with these findings, isolated blood and intestinal T cells from UC patients treated with UF resulted in a reduction in T cell activation, β7 integrin expression and IFNγ production as well as induction of apoptosis ( 164 ).…”

Section: Nutrients and Their Impact On Microbiota And Immune Responsementioning

confidence: 99%

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

et al. 2017

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Recent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host’s physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma.

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Section: Nutrients and Their Impact On Microbiota And Immune Responsementioning

confidence: 99%

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

et al. 2017

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“…A growing body of experimental and clinical evidence points to a link between a westernized diet, including a high intake of saturated fatty acids, and chronic inflammatory diseases ( 3 – 5 ). As dietary saturated and unsaturated fatty acids apparently modulate activity of immune cells, their influence on the immune responses triggered upon infection is also beginning to be investigated ( 6 ). These facts drive the interest in palmitic acid with an aim of elucidating the molecular mechanisms of its immunomodulatory properties.…”

Section: Introductionmentioning

confidence: 99%

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

et al. 2018

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S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage. S-palmitoylation determines the functioning of proteins by affecting their association with membranes, compartmentalization in membrane domains, trafficking, and stability. In this review, we focus on S-palmitoylation of proteins, which are crucial for the interactions of pathogenic bacteria and viruses with the host. We discuss the role of palmitoylated proteins in the invasion of host cells by bacteria and viruses, and those involved in the host responses to the infection. We highlight recent data on protein S-palmitoylation in pathogens and their hosts obtained owing to the development of methods based on click chemistry and acyl-biotin exchange allowing proteomic analysis of protein lipidation. The role of the palmitoyl moiety present in bacterial lipopolysaccharide and lipoproteins, contributing to infectivity and affecting recognition of bacteria by innate immune receptors, is also discussed.

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“…In contrast, while North American dietary guidelines recommend consuming omega-6 polyunsaturated fatty acids (n-6 PUFA), common in vegetable seed oils, excessive consumption of n-6 PUFA is a risk factor for IBD in humans [10]. In support of these findings, we have shown n-6 PUFA exacerbates murine colitis [9,11,12]. Conflicting data exists for dietary intake of saturated fatty acids (SFA), which have no double bonds and are found in dairy as well as coconut oil.…”

Section: Introductionmentioning

confidence: 74%

“…Yet, components of animal fat, such as butyric acid, suppress inflammation [16], protect against DSS-colitis [17] and stimulate colonic repair [18]. In line with this, we have shown that milk fat promotes beneficial responses during colitis [9]. While there is evidence that different dietary fatty acids have differential effects on host health, their effects on the gut bacterial ecosystem and their functional interaction with the host are not well explored.…”

Section: Introductionmentioning

confidence: 95%

“…In general, MUFA consumption is associated with health benefits including lower prevalence of digestive system cancers [6], decreased type 2 diabetes [7] and IBD [8]. Indeed, we have shown that olive oil diets are effective at protecting against murine colitis [9]. In contrast, while North American dietary guidelines recommend consuming omega-6 polyunsaturated fatty acids (n-6 PUFA), common in vegetable seed oils, excessive consumption of n-6 PUFA is a risk factor for IBD in humans [10].…”

Section: Introductionmentioning

confidence: 99%

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Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids

et al. 2019

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The dynamics of the tripartite relationship between the host, gut bacteria and diet in the gut is relatively unknown. An imbalance between harmful and protective gut bacteria, termed dysbiosis, has been linked to many diseases and has most often been attributed to high-fat dietary intake. However, we recently clarified that the type of fat, not calories, were important in the development of murine colitis. To further understand the host-microbe dynamic in response to dietary lipids, we fed mice isocaloric high-fat diets containing either milk fat, corn oil or olive oil and performed 16S rRNA gene sequencing of the colon microbiome and mass spectrometry-based relative quantification of the colonic metaproteome. The corn oil diet, rich in omega-6 polyunsaturated fatty acids, increased the potential for pathobiont survival and invasion in an inflamed, oxidized and damaged gut while saturated fatty acids promoted compensatory inflammatory responses involved in tissue healing. We conclude that various lipids uniquely alter the host-microbe interaction in the gut. While high-fat consumption has a distinct impact on the gut microbiota, the type of fatty acids alters the relative microbial abundances and predicted functions. These results support that the type of fat are key to understanding the biological effects of high-fat diets on gut health.

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Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice

Cited by 34 publications

References 44 publications

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids

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