Dietary Lipid and Postnatal Development. II. Palmityl Coenzyme A Oxidation in Heart and Liver

Aprille, June R.

doi:10.1203/00006450-197612000-00007

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…The capacity of heart (Wittels and Bressler, 1965 ;Warshaw and Terry, 1970 ;Warshaw, 1972 ;Mersmann and Phinney, 1973 ;Aprille, 1976 ;Wolfe, Maxwell and Nelson, 1978 ;Werner et al, 1982Werner et al, , 1983a, skeletal muscle (Wolfe, Maxwell and Nelson, 1978 ;Glatz and Veerkamp, 1982 ;Carroll et al, 1983) and kidney (Wolfe, Maxwell and Nelson, 1978 ;Freund, Sedraoui and Geloso, 1984) to oxidize NEFA increases shortly after birth in rats, rabbits, pigs and calves. In contrast, it has been reported that substantial fatty acid oxidation occurs only 2 weeks after birth in dog heart (Breuer et al, 1968).…”

Section: Introductionmentioning

confidence: 99%

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Fatty acid oxidation and ketogenesis during development

Girard¹,

Duée²,

Ferré³

et al. 1985

Reprod. Nutr. Dévelop.

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Section: Introductionmentioning

confidence: 99%

“…In contrast, it has been reported that substantial fatty acid oxidation occurs only 2 weeks after birth in dog heart (Breuer et al, 1968). Rosenthal and Warshaw (1977) (Aprille, 1976 ;Wolfe, Maxwell and Nelson, 1978).…”

Section: Introductionmentioning

confidence: 99%

Fatty acid oxidation and ketogenesis during development

Girard¹,

Duée²,

Ferré³

et al. 1985

Reprod. Nutr. Dévelop.

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“…Aprille [10] has shown that a fat-rich diet is not suf ficient per se to induce these maturational changes in metabolism in rabbit liver and heart. On the other hand, hormonal in fluences on the metabolic maturation of a variety of tissues and organs, (including liv er, brain and adipose tissue) are well docu mented [1 ,5 ,7 , 11-13], However, the poten tial role of hormones, especially insulin and glucagon, in promoting metabolic matura tion of mammalian myocardium has not been exhaustively explored.…”

Section: Introductionmentioning

confidence: 99%

Insulin Responsiveness of Neonatal Pig Myocardium

Sicard¹,

Werner²

1989

Neonatology

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The transition from preferential use of carbohydrates to fatty acids for energy production by neonatal mammalian myocardium might be hormonally influenced. In neonatal pigs (between 1 and 4 days of age), plasma glucose, lactate, and glucagon concentrations remained constant at adult levels, while plasma triglycerides and insulin content remained stable at substantially lower levels. Insulin, whether administered in vivo or during perfusion, increased myocardial glucose utilization [GU] and lactate production [LP]. Stimulation of GU and LP by insulin exposure in vivo persisted for at least 1 h during perfusions after insulin was removed. Exogenous lactate (0.5 mM) diminished insulin-stimulated GU and LP; and was used as a substrate at 1.25mM. Thus, insulin augmented glycolytic activity of neonatal piglet myocardium; however, exogenous lactate, within the physiological range, altered the nature of the myocardium’s response by, as yet, undetermined mechanisms. Therefore, the transition from carbohydrate to fatty acid utilization for energy production by the neonatal myocardium does not appear to result from decreased carbohydrate metabolism or reduced myocardial responsiveness to insulin.

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“…It has also 1979a). Several previous published papers demonbeen reported that fatty acids of medium chain strated the general lack of ability of tissues, length (C8-C12) are preferentially hydrolysed from especially liver and heart, of foetal and newborn triacylglycerols in the stomach and the intestine of animals to oxidize fatty acids 9-10-day-old suckling rats (Fernando-Warna- Warshaw & Terry, 1970;Bieber et al, 1973;Foster kulasuriya et al, 1981) and that there is a & Bailey, 1976; Aprille, 1976;Yeh & Zee, 1979).…”

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confidence: 99%

Development of fatty acid oxidation in neonatal guinea-pig liver

Shipp¹,

Parameswaran²,

Arinze³

1982

Biochemical Journal

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The capacity of foetal and neonatal liver to oxidize short-, medium- and long-chain fatty acids was studied in the guinea pig. Liver mitochondria from foetal and newborn animals were unable to synthesize ketone bodies from octanoate, but octanoylcarnitine and palmitoylcarnitine were readily ketogenic. The ketogenic capacity at 24 h after birth was as high as in adult animals. Hepatocytes isolated from term animals were unable to oxidize fatty acids, but at 6 h after birth production of 14CO2, acid-soluble products and acetoacetate from 1-14C-labelled fatty acids was 40-50% of the rates at 24 h. At 12 h of age these rates had already reached the 24 h values and did not change during suckling in the first week of life. The activities of hepatic fatty acyl-CoA synthetases, which were minimal in the foetus or at term, increased to maximal values in 12-24 h. The data show that the capacity for beta-oxidation and ketogenesis develops maximally in this species during the first 6-12 h after birth, and appears to be partly dependent on the development of fatty acid-activating enzyme.

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Dietary Lipid and Postnatal Development. II. Palmityl Coenzyme A Oxidation in Heart and Liver

Cited by 8 publications

References 11 publications

Fatty acid oxidation and ketogenesis during development

Fatty acid oxidation and ketogenesis during development

Insulin Responsiveness of Neonatal Pig Myocardium

Development of fatty acid oxidation in neonatal guinea-pig liver

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