Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity

Jahan, Marefa; Kracht, Susie; Ho, Yen Yi; Haque, Ziaul; Bhattachatyya, Birendra N.; Wynn, Peter; Wang, Bing

doi:10.1371/journal.pone.0185817

Cited by 24 publications

(19 citation statements)

References 47 publications

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“…Lactoferrin shows great potential as a postnatal therapy, in addition to positive effects antenatally. Lactoferrin is highly abundant in human colostrum and milk, and it reaches the brain after oral administration (197, 199). In this regard, breastfed infants show higher total anti-oxidant capacity and a lower oxidative stress index compared to non-breastfed infants.…”

Section: Specific Neonatal Morbidities (Table 1)mentioning

confidence: 99%

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

et al. 2019

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Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy complication of pathological reduced fetal growth, leading to significant perinatal mortality and morbidity, and subsequent long-term deficits. Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus. The neonatal morbidities associated with FGR depend on the timing of onset of placental dysfunction and growth restriction, its severity, and the gestation at birth of the infant. In this review, we explore the pathophysiological mechanisms involved in the development of major neonatal morbidities in FGR, and their impact on the health of the infant. Fetal cardiovascular adaptation and altered organ development during gestation are principal contributors to postnatal consequences of FGR. Clinical presentation, diagnostic tools and management strategies of neonatal morbidities are presented. We also present information on the current status of targeted therapies. A better understanding of neonatal morbidities associated with FGR will enable early neonatal detection, monitoring and management of potential adverse outcomes in the newborn period and beyond.

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Section: Specific Neonatal Morbidities (Table 1)mentioning

confidence: 99%

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

et al. 2019

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“…Maternal bLf supplementation increased the pregnancy rate, litter size, and survival, and the levels of IgA antibodies in the serum of gilts and their litter [122]. These findings indicate that bLf consumption provided benefits on survival and immunity during pregnancy and lactation.…”

Section: Lactoferrin: Modulatory Effects On the Gut Microbiotamentioning

confidence: 99%

The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria

Vega-Bautista

Garza

Carrero

et al. 2019

IJMS

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Lactoferrin (Lf) is an iron-binding milk glycoprotein that promotes the growth of selected probiotic strains. The effect of Lf on the growth and diversification of intestinal microbiota may have an impact on several issues, including (i) strengthening the permeability of the epithelial cell monolayer, (ii) favoring the microbial antagonism that discourages the colonization and proliferation of enteric pathogens, (iii) enhancing the growth and maturation of cell-monolayer components and gut nerve fibers, and (iv) providing signals to balance the anti- and pro-inflammatory responses resulting in gut homeostasis. Given the beneficial role of probiotics, this contribution aims to review the current properties of bovine and human Lf and their derivatives in in vitro probiotic growth and Lf interplay with microbiota described in the piglet model. By using Lf as a component in pharmacological products, we may enable novel strategies that promote probiotic growth while conferring antimicrobial activity against multidrug-resistant microorganisms that cause life-threatening diseases, especially in neonates.

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“…Recently, we have demonstrated a concentration‐dependency of Lf in upregulating intestinal gene expression of the brain‐derived neurotrophic factors (BDNF), UCHL1, and alkaline phosphatase activity, which alleviated early weaning diarrhea in postnatal piglets. [ 16 ] We also demonstrated maternal Lf supplementation during gestation and lactation improved pig production and immunity [ 17 ] and, in maternal nutritional interventional studies, was beneficial in reversing intrauterine growth restriction ‐induced sequela including morphological changes in the hippocampus in rodents. [ 18 ]…”

Section: Introductionmentioning

confidence: 99%

Functional Correlates and Impact of Dietary Lactoferrin Intervention and its Concentration‐dependence on Neurodevelopment and Cognition in Neonatal Piglets

Chen

Wang

Yang

et al. 2021

Molecular Nutrition Food Res

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Scope: Lactoferrin (Lf ), a sialylated milk glycoprotein, promotes early neurodevelopment and cognition. Functional concentrations of Lf, however, remain unknown. Our objective is to determine the concentration-dependency of Lf on genes associated with neurodevelopment and cognition in neonatal piglets. Methods and results: Piglets are given milk replacer with Lf at concentrations of 155 (low) or 285 mg kg -1 day -1 (high) from postnatal days 3 to 38. Gene expression associated with neurodevelopment, cognition, and cognate proteins were quantitated. This study found 1) The rate of learning and long-term memory was higher with 155 mg kg -1 day -1 assessed in an eight-arm radial maze; 2) Global gene transcription profiling showed this lower concentration upregulated genes and functions correlated with neurodevelopment and cognition, while the higher concentration regulated cellular processes for neuroprotection; 3) Expression of BDNF genes and proteins were higher with both concentrations, while genes regulating BDNF signaling, including SLC6A3, IGF-1 responded more to the lower concentration; 4) The lower concentration modulated genes in the five highest networks associated with cellularity and neurocognition, while the prevention of neurodevelopmental and neurological pathologies was associated with the higher concentration. Conclusion: The lower concentrations of Lf enhanced neurodevelopment and cognition, while higher concentrations are greater neuroprotective, findings of potential novel clinical relevance.

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Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity

Cited by 24 publications

References 47 publications

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria

Functional Correlates and Impact of Dietary Lactoferrin Intervention and its Concentration‐dependence on Neurodevelopment and Cognition in Neonatal Piglets

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