Dietary l-Arginine Supplementation Enhances the Reproductive Performance of Gilts

Mateo, R. D.; Wu, Guoyao; Park, Jun C.; Shinzato, I.; Kim, Sung Woo

doi:10.1093/jn/137.3.652

Cited by 264 publications

(233 citation statements)

References 37 publications

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“…This study utilized multiparous sow to better comprehend the status of oxidative stress during different stages of reproduction. The performance of all sows in this study was normal, which is similar to our previous publications, with regard to BW gain during gestation, BW changes during lactation, feed intake during gestation and lactation, litter size, litter birth weight and litter weight gain (Mateo et al, 2007(Mateo et al, , 2008(Mateo et al, and 2009Kim et al, 2009). In this study, there was no truly non-pregnant sow to compare the oxidative damage with pregnant sow because of practical difficulty in obtaining non-pregnant sows with similar age, parity and BW to those used in this study.…”

Section: Discussionsupporting

confidence: 90%

Oxidative stress status of highly prolific sows during gestation and lactation

Berchieri-Ronchi

Kim

Yan

et al. 2011

Animal

159

122

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Elevated oxidative stress is reported to be associated with pregnancy complications in highly prolific sows. Oxidative DNA damage and the antioxidant status were determined in blood samples collected during the course of gestation and lactation in multiparous sows. Blood samples were drawn from sows (n 5 5) on days 30, 60, 90 and 110 of gestation (G30, G60, G90 and G110, respectively), on day 3, 10 and 18 of lactation (L3, L10 and L18, respectively) and on day 5 of postweaning (W5). Lymphocytes were isolated from the fresh blood and cryopreserved in each time point. Lymphocyte DNA damage was analyzed by alkaline single-cell gel electrophoresis (comet assay) to determine the single-and double-strand brakes and endogenous antioxidant concentrations using an HPLC system with UV detection. The comet assay showed elevated (P , 0.05) DNA damage (between 38% and 47%) throughout the gestational and lactational periods than during early gestation (G30; 21%). Plasma retinol concentration was reduced (P , 0.05) at the end of gestation (G110) compared with G30. Plasma a-tocopherol concentrations also showed a similar trend as to retinol. This study indicates that there is an increased systemic oxidative stress during late gestation and lactation, which are not fully recovered until the weaning compared with the G30, and that antioxidant nutrients in circulation substantially reduced in the mother pig at G110.

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Section: Discussionsupporting

confidence: 90%

Oxidative stress status of highly prolific sows during gestation and lactation

Berchieri-Ronchi

Kim

Yan

et al. 2011

Animal

159

122

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“…By excluding the early gestation period, dietary Arg supplementation starting from day 22 or 30 of gestation and continuing until farrowing markedly improved placental growth and litter performance (Mateo et al, 2007;Gao et al, 2012). In this study, Arg supplemented to sows from day 30 to day 90 (Arg90 group) or 114 of gestation (Arg114 group) did not markedly increase total pigs born, however, the less dead pigs in sows receiving Arg between days 30-114 of gestation resulted in more live-born pigs, compared with sows with no Arg supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…putrescine, spermidine, and spermine), which are crucial for placental angiogenesis, trophoblast growth, and uteroplacental blood flow, thereby stimulating nutrients transfer and wastes exchange, consequently fetal growth and development (Wu et al, 2006). It has been reported that dietary Arg supplementation from early gestation until day 114 of gestation enhanced sow placental growth, litter size, and weight (Mateo et al, 2007;Gao et al, 2012). However, the sow placental growth has reached maximum in late gestation (McPherson et al, 2004;Freking et al, 2007), instead the efficient placenta in late gestation is physiologically required for rapid fetal growth in the last 20 days of gestation (Biensen et al, 1999;Macpherson et al, 2004).…”

mentioning

confidence: 99%

Effects of dietary arginine supplementation on reproductive performance and immunity of sows

Che¹,

Yang²,

Fang³

et al. 2013

Czech J. Anim. Sci.

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Arginine (Arg) is considered to have beneficial effects on placental development and function, as well as reproductive performance. The well-developed placenta is highly required in late gestation for rapid fetal growth, however, it is unknown if there is a crucial role of Arg in late gestation. Likewise, the immunological response of sows to Arg needs to be determined. Therefore, this study is designed to investigate the effects of dietary Arg supplementation on reproductive performance and immunity of sows. At day 30 of gestation, sixty sows (Landrace × Large White) were allocated to 3 groups receiving corn and soybean-based control diet (control group, n = 20), control diet supplemented with 1% l-arginine HCl until day 90 of gestation (Arg90 group, n = 20), and control diet supplemented with 1% l-arginine HCl until day 114 of gestation (Arg114 group, n = 20), respectively. Litter performance was recorded at parturition. Blood samples (n = 6) collected at days 30, 90, and 110 of gestation were measured for metabolic and immunological parameters. At parturition, total litter size was not affected by dietary Arg supplementation. As a result of less pigs born dead, however, sows in Arg114 group had more pigs born alive than sows in control group (+1.6 pigs, P < 0.05), total and live litter weights were increased (+1.6~2.1 kg, P < 0.05) in Arg114 group relative to both control and Arg90 groups. Compared with control group, dietary Arg supplementation increased (+12~110%, P < 0.05) plasma levels of ornithine, proline, and arginine at either day 90 (Arg90 and Arg110 groups) or day 110 of gestation (Arg110 group). Moreover, immune response was enhanced in Arg-supplemented sows, as indicated by the increased levels of serum immunoglobulin and porcine reproductive and respiratory syndrome virus (PRRSV) antibody. These findings indicate dietary Arg supplementation can improve litter performance and immune response, and the beneficial effect of Arg on fetal growth is evident in late gestation.

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“…Therefore, nutrient partitioning among fetuses is less variable as is within-litter variation in birth weight of piglets. However, there are other reports that do not indicate positive effects of dietary supplementation with L-arginine during mid-gestation to term on within-litter uniformity (Mateo et al, 2007;Gao et al, 2012). These different findings may be explained by differences in the total amounts of dietary L-arginine and other amino acids consumed by gestating pigs (Wu et al, 2013b;2013c).…”

Section: Nutrition Related To Fetal Growth During Late Gestationmentioning

confidence: 96%

“…Amino acids in the arginine family (arginine, glutamine, glutamate, proline, aspartate, asparagine, citrulline, and ornithine) have been studied extensively given their prominent effects in improving litter size (Greenberg et al, 1997;Hazeleger et al, 2007;Mateo et al, 2007;Gao et al, 2012;Li et al, 2014). At the same time, dietary supplementation with 25.5 g/d L-arginine from Day 77 of pregnancy until term reduced within-litter variation in birth weight of live-born piglets by 20.6% and 25.4% in arginine and control groups, respectively (Quesnel et al, 2014).…”

Section: Nutrition Related To Fetal Growth During Late Gestationmentioning

confidence: 99%

Within-litter variation in birth weight: impact of nutritional status in the sow

Yuan

Zhu

Shi

et al. 2015

J. Zhejiang Univ. Sci. B

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Accompanying the beneficial improvement in litter size from genetic selection for high-prolificacy sows, within-litter variation in birth weight has increased with detrimental effects on post-natal growth and survival due to an increase in the proportion of piglets with low birth-weight. Causes of within-litter variation in birth weight include breed characteristics that affect uterine space, ovulation rate, degree of maturation of oocytes, duration of time required for ovulation, interval between ovulation and fertilization, uterine capacity for implantation and placentation, size and efficiency of placental transport of nutrients, communication between conceptus/fetus and maternal systems, as well as nutritional status and environmental influences during gestation. Because these factors contribute to within-litter variation in birth weight, nutritional status of the sow to improve fetal-placental development must focus on the following three important stages in the reproductive cycle: pre-mating or weaning to estrus, early gestation and late gestation. The goal is to increase the homogeneity of development of oocytes and conceptuses, decrease variations in conceptus development during implantation and placentation, and improve birth weights of newborn piglets. Though some progress has been made in nutritional regulation of within-litter variation in the birth weight of piglets, additional studies, with a focus on and insights into molecular mechanisms of reproductive physiology from the aspects of maternal growth and offspring development, as well as their regulation by nutrients provided to the sow, are urgently needed.

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Dietary l-Arginine Supplementation Enhances the Reproductive Performance of Gilts

Cited by 264 publications

References 37 publications

Oxidative stress status of highly prolific sows during gestation and lactation

Oxidative stress status of highly prolific sows during gestation and lactation

Effects of dietary arginine supplementation on reproductive performance and immunity of sows

Within-litter variation in birth weight: impact of nutritional status in the sow

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