Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia

Malhotra, Anita; Shafiq, Nusrat; Arora, Atul; Singh, Meenu; Kumar, Rajendra; Malhotra, Samir

doi:10.1002/14651858.cd001918.pub3

Cited by 43 publications

(38 citation statements)

References 381 publications

(14 reference statements)

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“…Phytosterol supplementation at ;2 g/d has been shown to reduce serum cholesterol concentrations in the range of 8-16%, particularly in hypercholesterolemic individuals, including those with familial hypercholesterolemia (21,22) and dyslipidemic conditions associated with metabolic syndrome (23) and diabetes (24). Although the safety of phytosterol supplementation during pregnancy has been examined in a number of preclinical studies (25)(26)(27) and a human investigations (28) without any negative effects reported, the potential application of phytosterols as a cholesterol-lowering therapy for use in hypercholesterolemic pregnancies has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice

Rideout

Movsesian

Tsai

et al. 2015

The Journal of Nutrition

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Section: Introductionmentioning

confidence: 99%

Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice

Rideout

Movsesian

Tsai

et al. 2015

The Journal of Nutrition

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“…The intervention was developed for use in a research trial investigating the feasibility and acceptability of delivering an intervention aimed at reducing cardiovascular risk factors in individuals with FH through improving adherence to currently recommended dietary and physical activity treatment advice, described in full elsewhere (ISRCTN24880714). The trial aims to address the findings of recent systematic reviews which have highlighted the lack of evidence investigating the efficacy of providing this advice upon the management of CVD risk factors in this population group [39,40]. Given the available research Fig.…”

Section: The Feasibility Trialmentioning

confidence: 99%

The development of a theory informed behaviour change intervention to improve adherence to dietary and physical activity treatment guidelines in individuals with familial hypercholesterolaemia (FH)

Kinnear

Wainwright

Bourne

et al. 2020

BMC Health Serv Res

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Background: Familial hypercholesterolaemia (FH) is a genetic condition characterised by elevated levels of lowdensity lipoprotein cholesterol (LDL-C) and an increased risk of cardiovascular disease (CVD). Following dietary and physical activity guidelines could help minimise this risk but adherence is low. Interventions to target these behaviours are therefore required. A comprehensive understanding of the target behaviours and behaviour change theory should drive the process of intervention development to increase intervention effectiveness and scalability. This paper describes the application of a theoretical framework to the findings of a qualitative evidence synthesis (QES) to inform the content and delivery of an intervention to improve adherence to dietary and physical activity guidelines in individuals with FH. Methods: The Behaviour Change Wheel (BCW) was used to guide intervention development. Factors influencing dietary and physical activity behaviours were identified from an earlier QES and mapped onto factors within the BCW. A comprehensive behavioural diagnosis of these factors was conducted through application of the theoretical domains framework (TDF). Using these data, the most appropriate intervention functions and behaviour change techniques (BCTs) for inclusion in the intervention were identified. Decision making was guided by evaluation criteria recommended by BCW guidance and feedback from individuals with FH. Results: Factors influencing dietary and physical activity behaviours mapped onto twelve of the fourteen TDF domains, with seven intervention functions deemed suitable to target the domains' theoretical constructs. Twentysix BCTs were identified as being appropriate for delivery within these functions and were included in the intervention. For instance, within the enablement intervention function, the BCT problem solving was incorporated by inclusion of a 'barriers and solutions' section. Guided by evaluation criteria and feedback from individuals with FH, the intervention will be delivered as an hour-long family-based appointment, followed up with four telephone calls. Conclusions: The novel application of the BCW and TDF to the results of a QES has enabled the development of a theory and evidence informed behaviour change intervention. This systematic approach facilitates evaluation of the intervention as part of an ongoing feasibility trial. The transparent approach taken can be used to guide intervention development by researchers in other fields.

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“…Metanálise de 2014 estudou o efeito do uso de fitoesterol na redução dos níveis de LDL-Colesterol em crianças e adultos com Hipercolesterolemia Familiar e concluiu que o uso do fitoesterol como adjuvante à dieta de redução do colesterol teve impacto benéfico e estatisticamente significativo, apesar de não ter sido possível demonstrar se o uso desta medicação também reduziria eventos secundários, como incidência de DAC 54 .…”

Section: Terapêutica Das Dislipidemiasunclassified

Consenso da Associação Brasileira de Nutrologia sobre manejo da dislipidemia secundária à obesidade infanto-juvenil

Nogueira‐de‐Almeida¹,

Mello²,

Mello³

et al. 2018

Int J Nutrol

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RESUMO ObjetivoEstabelecer consenso sobre o manejo da dislipidemia secundária à obesidade infanto-juvenil. Métodos Foi realizada pesquisa bibliográfica nas bases de dados Medline, Scielo e LILACS. Com base nas evidências científicas, o grupo de trabalho estabeleceu as condutas recomendadas pelo Departamento de Nutrologia Pediátrica da ABRAN. Resultados Os autores redigiram o consenso que foi aprovado pela Diretoria da Associação Brasileira de Nutrologia -ABRAN. Conclusões São apresentadas, com base nas evidências científicas, as recomendações para a condução dos casos de dislipidemia associados à obesidade na infância e adolescência.Palavras-Chave: Dislipidemia, lipídeos, aterosclerose, crianças e adolescentes. INTRODUÇÃOA obesidade é um fenômeno global, cuja prevalência vem aumentando nas últimas décadas, chegando a assumir caráter de epidemia. Dados recentes confirmam o crescimento acelerado de indivíduos com excesso de peso também na população infanto-juvenil, que apresenta prevalência de sobrepeso de 31,6% nos Estados Unidos 1 . No Brasil, segundo os últimos dados do IBGE, 51,4% dos meninos e 43,8% das meninas entre 5 e 9 anos de idade apresentam excesso de peso, números que mostram a importância desta entidade mórbida na esfera da saúde pública 1, 2 . O acúmulo de gordura

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Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia

Abstract: Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia (Review)

Cited by 43 publications

References 381 publications

Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice

Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice

The development of a theory informed behaviour change intervention to improve adherence to dietary and physical activity treatment guidelines in individuals with familial hypercholesterolaemia (FH)

Consenso da Associação Brasileira de Nutrologia sobre manejo da dislipidemia secundária à obesidade infanto-juvenil

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