Dietary interventions and molecular mechanisms for healthy musculoskeletal aging

Murphy, Andrew W.; Vyavahare, Sagar; Kumar, Sandeep; Lee, Tae Jin; Sharma, Ashok; Adusumilli, Satish; Hamrick, Mark W.; Isales, Carlos M.; Fulzele, Sadanand

doi:10.1007/s10522-022-09970-1

Cited by 6 publications

(2 citation statements)

References 111 publications

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“…The GSTM1 gene experiences a frequent polymorphism resulting in a large deletion, with up to 50% of Caucasoid individuals being homozygous for this variant (GSTM1null) [36]. As to GSTM2, prior research has revealed the regulatory effect of GSTM2 on pulmonary [37], hepatic [38], skeletal muscle [39], and cardiac function [40], with particular emphasis on its antioxidant and detoxifying properties. Moreover, studies have shown that GSTM2 regulates tumor cell metastasis and treatment sensitivity [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA

Wu,

Yao,

et al. 2024

J Nanobiotechnol

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Skin aging is characterized by the disruption of skin homeostasis and impaired skin injury repair. Treatment of aging skin has long been limited by the unclear intervention targets and delivery techniques. Engineering extracellular vesicles (EVs) as an upgraded version of natural EVs holds great potential in regenerative medicine. In this study, we found that the expression of the critical antioxidant and detoxification gene Gstm2 was significantly reduced in aging skin. Thus, we constructed the skin primary fibroblasts-derived EVs encapsulating Gstm2 mRNA (EVsGstm2), and found that EVsGstm2 could significantly improve skin homeostasis and accelerate wound healing in aged mice. Mechanistically, we found that EVsGstm2 alleviated oxidative stress damage of aging dermal fibroblasts by modulating mitochondrial oxidative phosphorylation, and promoted dermal fibroblasts to regulate skin epidermal cell function by paracrine secretion of Nascent Polypeptide-Associated Complex Alpha subunit (NACA). Furthermore, we confirmed that NACA is a novel skin epidermal cell protective molecule that regulates skin epidermal cell turnover through the ROS-ERK-ETS-Cyclin D pathway. Our findings demonstrate the feasibility and efficacy of EVs-mediated delivery of Gstm2 for aged skin treatment and unveil novel roles of GSTM2 and NACA for improving aging skin. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA

Wu,

Yao,

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…The timely and appropriate dietary interventions may alleviate the ill effects of ageing associated with these two hallmarks. Another review article by Murphy et al (2022) summarizes the literature reports on the role of various dietary/nutritional interventions in relevance to their impact on bone and muscle health. Interestingly the authors analyzed several recent studies on CR regimens using Gene Expression Omnibus (GEO) database and made an attempt to link the CR/DR interventions to specific common transcriptome changes in the signaling molecules.…”

mentioning

confidence: 99%

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

Kaur

Sharma

2022

Biogerontology

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Characteristics of genetic basis copy number variation in production and adaptation traits of Chinese indigenous sheep

Jin,

Liu,

et al. 2024

Journal of Genetics and Genomics

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Dietary interventions and molecular mechanisms for healthy musculoskeletal aging

Cited by 6 publications

References 111 publications

Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA

Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

Characteristics of genetic basis copy number variation in production and adaptation traits of Chinese indigenous sheep

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