Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer Study

Wang, Zhenjie; Joshi, Amit Man; Ohnaka, Keizo; Morita, Makiko; Toyomura, Kengo; Kono, Suminori; Ueki, Takashi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Tomonori; Izutsu, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Katsuto; Ichimiya, Hitoshi; Terasaka, Reiji

doi:10.1080/01635581.2012.690927

Cited by 27 publications

(15 citation statements)

References 26 publications

(28 reference statements)

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“…Tocopherols and these triterpenes are fat-soluble antioxidants that scavenge ROS [34, 39, 40]. These compounds may have been responsible for the increased antioxidant activity of the EEPs observed in the assay with the free radical ABTS, as this method is applied to hydrophilic and lipophilic antioxidant systems [41].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Bonamigo

Campos

Alfredo

et al. 2017

Oxidative Medicine and Cellular Longevity

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Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations. The compounds stigmasterol, taraxasterol, vanilic acid, caffeic acid, quercetin, luteolin, and apigenin were found only in EEP-M. The EEPs were able to scavenge the free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and protected human erythrocytes against lipid peroxidation, with the latter effect being demonstrated by their antihemolytic activity and inhibition of malondialdehyde formation. The EEPs showed cytotoxic activity against erythroleukemic cells and necrosis was the main mechanism of death observed. In addition, the concentrations at which the EEPs were cytotoxic were not toxic against Caenorhabditis elegans. In this context, it is concluded that EEP-S and EEP-M show antioxidant and cytotoxic activities and are promising bioactive mixtures for the control of diseases associated with oxidative stress and tumor cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Bonamigo

Campos

Alfredo

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…46 Ascorbic acid cannot be synthesized by human cells and must be obtained from the diet and is typically metabolized by bacteria in the GI tract. 46 Intake of ascorbic acid has been disputed as protective against CRC, 47,48 and very little is known about the role of diketogulonic acid in CRC. In our subjects, there was no difference in ascorbic acid intake (dietary and supplemental) between cases and controls (data not shown), yet decreased levels of diketogulonic acid were observed in cases.…”

Section: Discussionmentioning

confidence: 99%

Altered Tissue Metabolites Correlate with Microbial Dysbiosis in Colorectal Adenomas

et al. 2014

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Several studies have linked bacterial dysbiosis with elevated risk of colorectal adenomas and cancer. However, the functional implications of gut dysbiosis remain unclear. Gut bacteria contribute to nutrient metabolism and produce small molecules termed the “metabolome”, which may contribute to the development of neoplasia in the large bowel. We assessed the metabolome in normal rectal mucosal biopsies of 15 subjects with colorectal adenomas and 15 nonadenoma controls by liquid chromatography and gas chromatography time-of-flight mass spectrometry. Quantitative real-time PCR was used to measure abundances of specific bacterial taxa. We identified a total of 274 metabolites. Discriminant analysis suggested a separation of metabolomic profiles between adenoma cases and nonadenoma controls. Twenty-three metabolites contributed to the separation, notably an increase in adenoma cases of the inflammatory metabolite prostaglandin E2 and a decrease in antioxidant-related metabolites 5-oxoproline and diketogulonic acid. Pathway analysis suggested that differential metabolites were significantly related to cancer, inflammatory response, carbohydrate metabolism, and GI disease pathways. Abundances of six bacterial taxa assayed were increased in cases. The 23 differential metabolites demonstrated correlations with bacteria that were different between cases and controls. These findings suggest that metabolic products of bacteria may be responsible for the development of colorectal adenomas and CRC.

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“…While some forms of collagens have been linked to the inhibition of tumor growth [63], epidemiological studies examining the range of vitamin C intake that can affect the collagen maturation found either a small reduction or no change in cancer risk at higher dietary vitamin C intake [64][65][66]. One possible explanation is that the extracellular matrix is composed of various collagen family members and the net contribution of good-quality collagens may not be growth inhibitory.…”

Section: Cancersmentioning

confidence: 99%

The Multifaceted Biological Roles of Vitamin C

Kuo¹

2013

J Nutr Food Sci

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Scurvy due to severe vitamin C (ascorbic acid) deficiency among sailors was one of the earliest documented occupational diseases. This review first discussed some reduction potential-based biochemical activities of vitamin C such as assisting the post-translational collagen modification as well as acting as an antioxidant and pro-oxidant. These known activities of vitamin C were then used to address recent outcomes of vitamin C clinical trials on the prevention and treatment of non-scurvy diseases such as cardiovascular diseases and cancer. The pro-oxidant activity may contribute to the adverse effect of high-level vitamin C supplementation in clinical trials.

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Dietary Intakes of Retinol, Carotenes, Vitamin C, and Vitamin E and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer Study

Cited by 27 publications

References 26 publications

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Antioxidant, Cytotoxic, and Toxic Activities of Propolis from Two Native Bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides

Altered Tissue Metabolites Correlate with Microbial Dysbiosis in Colorectal Adenomas

The Multifaceted Biological Roles of Vitamin C

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