Dietary Intake of Vegetables and Cooking Oil Was Associated With Drug-Induced Liver Injury During Tuberculosis Treatment: A Preliminary Cohort Study

Abstract

Background and Purpose: Drug-induced liver injury is challenging during tuberculosis treatment. There is no epidemiological data investigating the relation between dietary intake and the risk of drug-induced liver injury during tuberculosis treatment. The aim of this study is to investigate the association of food and nutrient intake with the incidence of tuberculosis-drug-induced liver injury.Methods: A cohort study was conducted in two city-level tuberculosis-specialized hospitals in Linyi City and Qingdao City, China from January 2011 to December 2013. The dietary intake was assessed by a 3-day 24-h food recall survey and a standard food-frequency questionnaire. The liver functions including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were monitored throughout the 6-month tuberculosis therapy. Liver injury was defined as ALT or AST higher than two times of the upper limit of normal (ULN). Liver dysfunction was defined as ALT or AST higher than the ULN. The ULN for ALT and AST is 40 U/L. Multivariate logistic regression analyses were performed to determine the dietary factors associated with the incidence of liver injury and liver dysfunction.Results: A total of 605 patients were included in the analysis. During the treatment, 8.1% patients exhibited liver injury and 23.3% patients exhibited liver dysfunction. A lower intake of vegetables was associated with a higher risk of liver injury [OR (95% CI): 3.50 (1.52–8.08), P = 0.003) and liver dysfunction [OR (95% CI): 2.37 (1.31–4.29), P = 0.004], while a lower intake of cooking oil was associated with a lower risk of liver injury [OR (95% CI): 0.44 (0.20–0.96), P = 0.040)] and liver dysfunction [OR (95% CI): 0.51 (0.31–0.85), P = 0.009].Conclusion: The current study indicated that the higher risks of tuberculosis-drug-induced liver injury and liver dysfunction were statistically associated with decreased vegetable intake and increased cooking oil intake.

Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects

“…The decreased levels of ALT, AST, and MDA in the present study agree with previous findings that represented the protective effect of VC on the liver of carbon tetrachloride-intoxicated rats ( 28 , 29 ). Several studies have reported that VC produces a protective effect against drugs and chemical agents that induce hepatotoxicity ( 28 , 29 ).…”

“…The decreased levels of ALT, AST, and MDA in the present study agree with previous findings that represented the protective effect of VC on the liver of carbon tetrachloride-intoxicated rats ( 28 , 29 ). Several studies have reported that VC produces a protective effect against drugs and chemical agents that induce hepatotoxicity ( 28 , 29 ). The target of VC is the mitochondria, preventing mitochondrial swelling, mitochondrial membrane potential dissipation, and ROS burst, thereby preventing hepatic apoptosis; these effects may oppose the action of MTX ( 15 , 20 ).…”

Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies

“…In addition to drug treatment, the potential role of dietary components hasreceived increased attention. Previous studies have shown the effectiveness of healthy dietary patterns and components for the prevention of CVD and other diseases [ 2 , 3 , 4 ]. Fish is rich in various nutrients (e.g., protein, vitamin D and polyunsaturated fatty acids) and may have a beneficial role in preventing CVD events [ 5 , 6 ].…”

Nutritional intervention is promising in alleviating liver injury during tuberculosis treatment: a review

“…The relationship between protein, micronutrients deficiency and the incidence of TBLI was rarely explored and may be a future research direction. Our recent cohort study ( 108 ) indicated that a high vegetable intake and a low cooking oil intake were associated with a reduced risk of TBLI. An optimal dietary pattern may be further investigated for reducing the risk of TBLI.…”