Dietary intake of table olives exerts antihypertensive effects in association with changes in gut microbiota in spontaneously hypertensive rats

Gómez-Contreras, Aldo; Franco-Ávila, Talia; Miró, Lluïsa; Juan, M. Emília; Moretó, Miquel; Planas, Joana M.

doi:10.1039/d2fo02928f

Cited by 2 publications

(2 citation statements)

References 53 publications

(115 reference statements)

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“…The doses administered to the rats are equivalent to the human consumption of 30 and 60 Arbequina table olives and were selected because the intake of 30 olives was double to one serving according to the Mediterranean diet pyramid . Moreover, this dosage is relevant to health because the administration of 3.85 g/kg to spontaneously hypertensive rats decreased blood pressure, being the antihypertensive effect associated with changes in the concentration of angiotensin II, malondialdehyde as well as gut microbiota remodeling . Our results have demonstrated that hydroxytyrosol provided in table olives, although extensively metabolized, remained in plasma during 8 h. Therefore, table olives can be considered an efficient vehicle to deliver hydroxytyrosol, thus, emerging as a functional food.…”

Section: Introductionmentioning

confidence: 74%

Pharmacokinetics of Hydroxytyrosol and Its Sulfate and Glucuronide Metabolites after the Oral Administration of Table Olives to Sprague-Dawley Rats

Kundisová,

Colom,

Juan

et al. 2024

J. Agric. Food Chem.

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The pharmacokinetics (PK) of hydroxytyrosol and its metabolites were characterized following oral administration to Sprague-Dawley rats of 3.85 and 7.70 g of destoned Arbequina table olives/kg. Plasma samples were analyzed using a fully validated method consisting of liquid extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Noncompartmental PK analysis of hydroxytyrosol demonstrated linear PK between doses of 2.95 and 5.85 mg hydroxytyrosol/kg. Half-life was approximately 2.5 h, while mean residence time was around 4 h. Clearance occurred by conversion to two sulfate and two glucuronide conjugates. The area under the plasma concentration–time curve (AUC) ratios of metabolites versus parent hydroxytyrosol was approximately 7–9-fold for the sulfate and below 0.25 for the glucuronide, indicating sulfation as the predominant metabolic pathway. Despite extensive metabolism, hydroxytyrosol remained in plasma for up to 8 h with AUCs of 4293 and 8919 min·nmol/L for the doses of 3.85 and 7.70 g/kg, respectively. Therefore, table olives provide a more sustained plasma profile than other foods containing hydroxytyrosol, which may enhance its health-protecting activities.

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Section: Introductionmentioning

confidence: 74%

Pharmacokinetics of Hydroxytyrosol and Its Sulfate and Glucuronide Metabolites after the Oral Administration of Table Olives to Sprague-Dawley Rats

Kundisová,

Colom,

Juan

et al. 2024

J. Agric. Food Chem.

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“…Furthermore, our study demonstrated that the RPP intervention led to a significant downregulation of the amount of Ruminococcus, as well as the conditionally pathogenic bacterium Bacteroides. Ruminococcus is known to produce inflammatory polysaccharides that disrupt intestinal barrier function [46], and its reduction has been associated with improved hypertension [47]. These results suggest that RPPs could contribute to the maintenance of gut microbiota stability.…”

Section: Discussionmentioning

confidence: 93%

Bioactive Peptides from Ruditapes philippinarum Attenuate Hypertension and Cardiorenal Damage in Deoxycorticosterone Acetate–Salt Hypertensive Rats

Sun,

Wang,

Liu

et al. 2023

Molecules

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Hypertension is a common disease that affects human health and can lead to damage to the heart, kidneys, and other important organs. In this study, we investigated the regulatory effects of bioactive peptides derived from Ruditapes philippinarum (RPP) on hypertension and organ protection in deoxycorticosterone acetate (DOCA)–salt hypertensive rats. We found that RPPs exhibited significant blood pressure-lowering properties. Furthermore, the results showed that RPPs positively influenced vascular remodeling and effectively maintained a balanced water–sodium equilibrium. Meanwhile, RPPs demonstrated anti-inflammatory potential by reducing the serum levels of inflammatory cytokines (TNF-α, IL-2, and IL-6). Moreover, we observed the strong antioxidant activity of RPPs, which played a critical role in reducing oxidative stress and alleviating hypertension-induced damage to the aorta, heart, and kidneys. Additionally, our study explored the regulatory effects of RPPs on the gut microbiota, suggesting a possible correlation between their antihypertensive effects and the modulation of gut microbiota. Our previous studies have demonstrated that RPPs can significantly reduce blood pressure in SHR rats. This suggests that RPPs can significantly improve both essential hypertension and DOAC–salt-induced secondary hypertension and can ameliorate cardiorenal damage caused by hypertension. These findings further support the possibility of RPPs as an active ingredient in functional anti-hypertensive foods.

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Dietary intake of table olives exerts antihypertensive effects in association with changes in gut microbiota in spontaneously hypertensive rats

Abstract: Arbequina table olive (AO) consumption lowers blood pressure (BP) in spontaneously hypertensive rats (SHR). This study evaluates whether dietary supplementation with AO induced changes in the gut microbiota that are...

Cited by 2 publications

References 53 publications

Pharmacokinetics of Hydroxytyrosol and Its Sulfate and Glucuronide Metabolites after the Oral Administration of Table Olives to Sprague-Dawley Rats

Pharmacokinetics of Hydroxytyrosol and Its Sulfate and Glucuronide Metabolites after the Oral Administration of Table Olives to Sprague-Dawley Rats

Bioactive Peptides from Ruditapes philippinarum Attenuate Hypertension and Cardiorenal Damage in Deoxycorticosterone Acetate–Salt Hypertensive Rats

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