Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia

An, Jun-Mo; Kang, Eung Shick; Han, Young‐Min; Oh, Ji Young; Lee, Dong Yoon; Choi, Sun-Hye; Kim, Duk Hwan; Hahm, Ki Baik

doi:10.3164/jcbn.19-10

Cited by 27 publications

(25 citation statements)

References 48 publications

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“…After checking their reference lists, we excluded reviews, book chapters, case reports, conference articles, and study protocols, which resulted in 35 research articles being left. These articles were screened fully to assess their eligibility, and eight articles were accepted for inclusion based on exposure, study population, and outcome measures [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. After reviewing the reference lists of the included articles and broadening the term “disease” to (“heart failure” OR COPD OR “renal failure” OR HIV), one additional study was included in the review [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review—Gut Permeability as Potential Treatment Target

et al. 2021

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Muscle wasting is a frequently observed, inflammation-driven condition in aging and disease, known as sarcopenia and cachexia. Current treatment strategies target the muscle directly and are often not able to reverse the process. Because a reduced gut function is related to systemic inflammation, this might be an indirect target to ameliorate muscle wasting, by administering pro-, pre-, and synbiotics. Therefore, this review aimed to study the potential of pro-, pre-, and synbiotics to treat muscle wasting and to elucidate which metabolites and mechanisms affect the organ crosstalk in cachexia. Overall, the literature shows that Lactobacillus species pluralis (spp.) and possibly other genera, such as Bifidobacterium, can ameliorate muscle wasting in mouse models. The beneficial effects of Lactobacillus spp. supplementation may be attributed to its potential to improve microbiome balance and to its reported capacity to reduce gut permeability. A subsequent literature search revealed that the reduction of a high gut permeability coincided with improved muscle mass or strength, which shows an association between gut permeability and muscle mass. A possible working mechanism is proposed, involving lactate, butyrate, and reduced inflammation in gut–brain–muscle crosstalk. Thus, reducing gut permeability via Lactobacillus spp. supplementation could be a potential treatment strategy for muscle wasting.

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Section: Resultsmentioning

confidence: 99%

The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review—Gut Permeability as Potential Treatment Target

et al. 2021

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“…Cachexia is characterized by the activation of systemic inflammation, which is reflected by increased serum levels of C-reactive protein [ 57 ]; however, the catabolic drive during cancer cachexia can also be reflected by other cytokines, including IL-6 and TNFα. Increased levels of these cytokines were reported in association with sarcopenia and cachexia during conditions such as aging [ 58 , 59 ] and cancer [ 60 ], and nutritional interventions targeted at suppressing inflammation were shown to ameliorate cancer cachexia in experimental models [ 61 ]. The effects of protein and amino acid supplementation alone or associated with other interventions on serum concentrations of proinflammatory cytokines were investigated in three studies [ 36 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review

Zanetti¹,

Cappellari²,

Barazzoni³

et al. 2020

Nutrients

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Deterioration of muscle strength during cancer results in functional limitation, poor quality of life and reduced survival. The indirect effects on muscle strength of nutritional interventions based on protein and amino acid derivatives targeted at improving muscle mass are poorly documented. A scoping review was performed to examine the available evidence on the effects of proteins, amino acids and their derivatives on muscle strength in adult cancer patients. Pubmed and Scopus databases were searched to identify research articles published in the last 10 years. Fourteen studies met the inclusion criteria, showing that changes in muscle strength following protein or amino acid supplementation are generally concordant with those in muscle mass in cancer patients. Administration of both energy and proteins in the presence of reduced oral intakes results in more robust effects on both muscle strength and mass. It is not clear whether this is due to the correction of the energy deficit or to an interaction between proteins and other macronutrients. The optimal mixture, type, and dose of amino acid/protein supplementation alone or in combination with other anabolic strategies should be determined to provide the best nutritional approach in cancer.

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“…Therefore, multimodal comprehensive treatment should be adopted to delay muscle atrophy caused by cachexia. related measures include activating the Pi3K/aKT/mTor signaling pathway (138,139), inhibiting the UPS (140,141), proinflammatory factors (142), signal transduction pathways (53,143) and transcription factors (144), and regulating the expression of certain organelles (145) and receptors (146) related to muscle atrophy caused by cancer cachexia.…”

Section: Treatment Of Muscle Atrophy Caused By Cancer Cachexiamentioning

confidence: 99%

“…A previous study identified that IL-6 and its receptor, as well as JAK2 and STAT3 were significantly attenuated with kimchi. Kimchi was discovered to be a potential option to ameliorate cancer cachexia through its ability to suppress il-6 and decrease muscle atrophy in a c26 mouse model (142). in addition, in an experimental model of c26-induced cancer cachexia, 20S, 21-epoxy-resibufogenin-3-acetate (erBa) markedly inhibited body weight loss.…”

Section: Treatment Of Muscle Atrophy Caused By Cancer Cachexiamentioning

confidence: 99%

“…in addition, in an experimental model of c26-induced cancer cachexia, 20S, 21-epoxy-resibufogenin-3-acetate (erBa) markedly inhibited body weight loss. erBa is a specific small molecule with il-6 receptor antagonist activity (142). Furthermore, another previous study revealed that aerobic interval training enhanced the il-10/TnF-α ratio, an anti-inflammatory index, and IL-15 expression levels in the skeletal muscle of tumor-bearing mice (153).…”

Section: Treatment Of Muscle Atrophy Caused By Cancer Cachexiamentioning

confidence: 99%

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Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)

Huang

et al. 2020

Mol Med Rep

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Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer, including pancreatic, lung and gastric cancers. cancer cachexia is a multifactorial syndrome characterized by a continuous decline in skeletal muscle mass that cannot be reversed by conventional nutritional therapy. The pathophysiological characteristic of cancer cachexia is a negative protein and energy balance caused by a combination of factors, including reduced food intake and metabolic abnormalities. numerous necessary cellular processes are disrupted by the presence of abnormal metabolites, which mediate several intracellular signaling pathways and result in the net loss of cytoplasm and organelles in atrophic skeletal muscle during various states of cancer cachexia. currently, the clinical morbidity and mortality rates of patients with cancer cachexia are high. once a patient enters the cachexia phase, the consequences are difficult to reverse and the treatment methods for cancer cachexia are very limited. The present review aimed to summarize the recent discoveries regarding the pathogenesis of cancer cachexia-induced muscle atrophy and provided novel ideas for the comprehensive treatment to improve the prognosis of affected patients. Contents 1. introduction 2. activation of the uPS 3. Induction of proinflammatory factors 4. regulation of signaling pathways, transcription factors and micrornas (mirnas/mirs) 5. cell autophagy/lysosomal and ca 2+-dependent protein degradation pathways 6. endoplasmic reticulum stress and mitochondrial dysfunction 7. other receptors and substances that affect metabolism 8. Treatment of muscle atrophy caused by cancer cachexia 9. conclusion

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Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia

Cited by 27 publications

References 48 publications

The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review—Gut Permeability as Potential Treatment Target

The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review—Gut Permeability as Potential Treatment Target

The Impact of Protein Supplementation Targeted at Improving Muscle Mass on Strength in Cancer Patients: A Scoping Review

Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)

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