Dietary intake of one-carbon metabolism-related nutrients and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort

Abstract

Dietary intake of one-carbon metabolism-related nutrients has been linked to cancer-related outcomes, but their effects on hepatocellular carcinoma (HCC) mortality are still unknown. The objective was to assess whether pre-diagnostic...

High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations

“…Six studies (four case-control and two cohort studies) addressed the association between vitamin B12 (plasma concentration and/or intake) and hepatic cancer or mortality after the diagnosis of hepatic cancer [ 7 , 8 , 9 , 10 , 11 , 12 ]. The exposure in five of those studies was serum/plasma B12, while one study additionally investigated vitamin B12 intake [ 7 ] and one study investigated only vitamin B12 intake [ 12 ].…”

“…Six studies (four case-control and two cohort studies) addressed the association between vitamin B12 (plasma concentration and/or intake) and hepatic cancer or mortality after the diagnosis of hepatic cancer [ 7 , 8 , 9 , 10 , 11 , 12 ]. The exposure in five of those studies was serum/plasma B12, while one study additionally investigated vitamin B12 intake [ 7 ] and one study investigated only vitamin B12 intake [ 12 ]. The reference categories of plasma B12 concentrations in the individual studies were based on the within-study data distribution and showed large variations between the studies (i.e., reference categories of plasma B12 were <699 ng/L (or 516 pmol/L); 227–265 pmol/L; <154 pmol/L; and 200–600 pmol/L).…”

“…Vitamin B12 intake did not differ between patients with liver cancer and the controls and the intake was also not associated with the plasma concentrations of B12 [ 7 ]. No association was found between pre-diagnostic B12 intake and all-cause mortality and hepatic cancer-specific mortality during 791 days follow up among patients recently diagnosed with liver cancer [ 12 ].…”

“…Lin et al found that higher plasma B12 concentrations were associated with liver cancer, while B12 intake did not differ between cases and controls [ 7 ]. These results, combined with the lack of association between pre-diagnostic B12 intake and cancer [ 12 ], strongly suggest that high plasma B12 is not explained by high vitamin B12 intake. Lin et al also reported associations between high plasma vitamin B12 concentrations and tumor size, the degree of liver injury, and tumor progression [ 7 ], suggesting that with progression of the tumor and liver damage, vitamin B12 (of so far unknown origin) is increasingly trapped in the circulation.…”

Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases

“…Shotgun proteomics analysis indicated a significant decrease of methionine metabolism enzymes (MAT1A, GNMT, and AHCY) and trans-sulfuration pathway enzyme (CBS) after PH (Figure 6B). Since OCM is essential in maintaining quiescent and differentiated hepatocytes, [43][44][45][46] and its regulation during LR is poorly understood, we have performed a systematic analysis of 12 enzymes involved in this pathway. To this end we used a standardized PRM assay targeting enzymes catalyzing reactions of the methionine cycle (MAT1A, MAT2A, MAT2B, GNMT, AHCY, BHMT, and MTAP), the folate cycle (SHMT1 and 2, DHFR), and the transsulfuration pathways (CTH and CBS).…”