Dietary intake of omega fatty acids and polyphenols and its relationship with the levels of inflammatory markers in men with chronic coronary syndrome after percutaneous coronary intervention

Abstract

It has been established as an independent prognostic factor for CVD. 3 Furthermore, it can be used as a predictor of acute and long-term death after percutaneous coronary intervention (PCI). 4 Similarly to the PLR, the NLR can be calculated based on complete blood count. It has been reported to have a prognostic value in CVD and is regarded as an independent predictor of cardiovascular death and long-term mortality in patients after PCI. 5 C-reactive protein is an acute-phase protein produced by the liver

Inflammation and its resolution in coronary artery disease: a tightrope walk between omega-6 and omega-3 polyunsaturated fatty acids

“…Taken together, the study by Sut et al 3 is an important contribution to the current knowledge on the dietary effects on inflammation in general and, in particular, on the role of the omega-6 / omega-3 PUFA ratio as The association of a higher ratio of dietary omega-6 / omega-3 PUFAs with inflammation reported by Sut et al 3 may hence potentially reflect an imbalance between proinflammatory and proresolving mediators derived from omega-6 and omega-3 PUFAs, respectively. Indeed, several downstream PUFA -derived lipid mediators have been shown to directly regulate the atherosclerotic process.…”

“…stratifying the study population by a dietary ratio of omega-6 to omega-3 PUFAs revealed significantly higher CRP levels in subjects with the ratio higher than 4:1. 3 These results indicate that the relative intake of omega-6 and omega-3 PU-FAs may reveal significant associations with inflammation in CAD. The latter assumption is supported by studies in healthy volunteers showing that a high omega-6 / omega-3 PUFA ratio is associated with increased levels of inflammatory biomarkers such as CRP or tumor necrosis factor α.…”

“…Furthermore, since a majority of patients with CAD are put on complex medication regimens, a possible drug -related interaction effect on protective PUFA characteristics should be further explored. Finally, it should be noted that the Food Frequency Questionnaire may have overestimated the PUFA intake, since the median omega-3 PUFA intake was reported to be 4.2 g/d, 3 which is remarkably high.…”

“…4 In contrast, polyphenol intake did not predict any of the inflammatory marker levels. 3 A closer look at the downstream metabolism of PUFAs may provide additional insights into the role of the omega-6 / omega-3 PUFA ratio in coronary atherosclerosis. Indeed, omega-6 PUFAs are fatty acids responsible for the proinflammatory response, serving as a substrate for the production of the proinflammatory lipid mediators: leukotrienes and prostaglandins.…”

“…Importantly, considered before they can be fully applied to dietary advice and clinical practice. The multiparametric approach for determining dietary anti--inflammatory effects based on CRP, PLR, and NLR values, advocated by Sut et al, 3 must be further studied since the results were obtained in a cohort that included only men with previously diagnosed CAD. No control of known cardiovascular confounding factors (absence of multivariable / multivariate analyses) also weakens the intrinsic validity of the study.…”