Dietary intake of mother in childbearing age with BMI &lt;18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v)

Parwanto, ML Edy; Senjaya, Hardy

doi:10.18203/2394-6040.ijcmph20170264

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…In detail, that differences of dietary intake at mother in childbearing age with BMI <18.5 kg/m 2 and has heterozygous variant SHBG genotype (W/v) determine to status of chronic energy deficiency (CED), therefore that low protein, fat and carbohydrate intake then getting low of CED status. 15 We suspect that beside of genetic factor, environment factor such as dietary intake also affected to ACG. Because that too need of ACG reports from genetic aspect and dietary intake.…”

Section: Introductionmentioning

confidence: 98%

The genetic aspect and morphological appearance of achondrogenesis

Parwanto

2017

Int J Reprod Contracept Obstet Gynecol

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Achondrogenesis (ACG) is a number of disorders that are the most severe form of congenital chondrodysplasia characterized with bones and cartilage malformation. Generally, characteristic of ACG is a small body, short limbs, and other skeletal abnormalities. As a result of infants with ACG their serious health problems, usually born prematurely, are stillborn, or die shortly after birth from respiratory failure. Currently 3 type variants of ACG such as ACG-1A, ACG-1B and ACG-2. ACG-1A appears to be autosomal recessive (AR), with thyroid hormone receptor interactor 11 (TRIP11) gen mutation, while ACG1B also appears to be AR, with diastrophic dysplasia sulfate transporter or DTDST (SLC26A2) gen mutation. ACG-2 is caused by autosomal dominant (AD), with type 2 collagen (COL2A1) gen mutation. ACG-1A had characterizid such as physis abnormal, vertebral bodies with unossified or smal and oval, skull poorly ossified, periodic acid–Schiff (PAS) stain positive chondrocyte inclusions finding in long bones. ACG-1B had physis abnormal, vertebral bodies with unossified or smal and oval, skull ossified, perichondrocyte collagen rings finding in long bones. ACG-2 also had physis abnormal, metaphyseal cupping, vertebral bodies with unossified or small and oval, enlarged chondrocyte lacunae.

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Section: Introductionmentioning

confidence: 98%

The genetic aspect and morphological appearance of achondrogenesis

Parwanto

2017

Int J Reprod Contracept Obstet Gynecol

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“…This is in accordance with research that shows that subjects with a BMI of <18.5 kg/m 2 actually have a low intake of macronutrients (proteins, fats, and carbohydrates), resulting in chronic energy deficiency with a low status. 46…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength as an indicator of decreased cognitive function in the elderly

Alyssa

Parwanto

2022

Int J Res Med Sci

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In the elderly, the aging process occurs which is associated with a decrease in several functions in the body, including cognitive function and musculoskeletal function. According to the Centers for Disease Control (CDC), 1 in 9 elderly’s has decreased cognitive function. This decline in cognitive function is a form of cognitive dysfunction and is a precursor to the symptoms of Alzheimer's disease and other dementias. According to one study, the prevalence of people who were not detected for dementia because they had never undergone a cognitive examination was 61.7%. One of the possible causes is the absence of cognitive examinations in primary health facilities due to the unavailability of fast and easy instruments. Low hand grip strength has been associated with decreased cognitive function, and can be an effective indicator for early detection of cognitive impairment. In addition, hand grip strength can also be a predictor of decreased cognitive function in the elderly. The exact mechanism between decreased motor power and cognitive function is still unclear. Probably caused by the same cause like the presence of neuropathology in brain such as Lewy bodies, amyloid plaques, neurofibrillary tangles, infarction and atrophy.

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“…The results showed that subjects with BMI <18.5 kg/m2 actually had a low intake of macronutrients (protein, fat, and carbohydrates), resulting in chronic energy deficiency with low status. (93) Based on the results of this study, the intake of macronutrients must be met so that the elderly do not experience chronic energy deficiency and their quality of life becomes better.…”

Section: Systematic Review and Metaanalysismentioning

confidence: 98%

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

Parwanto,

Tjahyadi,

Amalia

et al. 2023

Univ Med

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The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.

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Dietary intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v)

Cited by 5 publications

References 27 publications

The genetic aspect and morphological appearance of achondrogenesis

The genetic aspect and morphological appearance of achondrogenesis

Handgrip strength as an indicator of decreased cognitive function in the elderly

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

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