Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis

Barros, A.; M, Felipe; Barbosa, Isabelle Ribeiro; Leite-Lais, Lúcia; Pedrosa, Lúcia Fátima Campos

doi:10.3390/metabo13060696

Cited by 4 publications

(2 citation statements)

References 74 publications

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“…SleP has been reported to be able to deliver selenium into brain, protect brain from peroxynitrite-mediated oxidation and nitration, and combine with heavy metals as chelation antidote in brain [70][71][72][73][74][75]. It has been demonstrated as the most efficient [59][60][61][62][63][64]66]; (e) relationship between selenium level in Huntington's disease patients and Huntington's disease [67]. Note: SD, standard deviation; Std.…”

Section: Discussionmentioning

confidence: 99%

Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis

Zhou,

Zhang,

Cao

et al. 2023

Nutrients

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Background: Neurodegenerative diseases (NDs) have posed significant challenges to public health, and it is crucial to understand their mechanisms in order to develop effective therapeutic strategies. Recent studies have highlighted the potential role of selenium in ND pathogenesis, as it plays a vital role in maintaining cellular homeostasis and preventing oxidative damage. However, a comprehensive analysis of the association between selenium and NDs is still lacking. Method: Five public databases, namely PubMed, Web of Science, EMBASE, Cochrane and Clinical Trials, were searched in our research. Random model effects were chosen, and Higgins inconsistency analyses (I2), Cochrane’s Q test and Tau2 were calculated to evaluate the heterogeneity. Result: The association of selenium in ND patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) was studied. A statistically significant relationship was only found for AD patients (SMD = −0.41, 95% CI (−0.64, −0.17), p < 0.001), especially for erythrocytes. However, no significant relationship was observed in the analysis of the other four diseases. Conclusion: Generally, this meta-analysis indicated that AD patients are strongly associated with lower selenium concentrations compared with healthy people, which may provide a clinical reference in the future. However, more studies are urgently needed for further study and treatment of neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis

Zhou,

Zhang,

Cao

et al. 2023

Nutrients

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“…Choline deficiency is associated with liver damage and/or muscle damage [ 128 ]. In a recent study conducted on a small cohort of sALS patients, prevalence of folate deficiency was considered severe and correlated with disease severity, along with other vitamin deficiencies [ 130 ]. In addition, excessive alcohol consumption, smoking, and ionizing radiations have also been associated with altered 1C metabolism or DNAm [ 131 , 132 , 133 ].…”

Section: Environmental and Developmental Impacts On 1c Metabolismmentioning

confidence: 99%

From Environment to Gene Expression: Epigenetic Methylations and One-Carbon Metabolism in Amyotrophic Lateral Sclerosis

Hernan-Godoy,

Rouaux

2024

Cells

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The etiology of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) is complex and considered multifactorial. The majority of ALS cases are sporadic, but familial cases also exist. Estimates of heritability range from 8% to 61%, indicating that additional factors beyond genetics likely contribute to ALS. Numerous environmental factors are considered, which may add up and synergize throughout an individual’s lifetime building its unique exposome. One level of integration between genetic and environmental factors is epigenetics, which results in alterations in gene expression without modification of the genome sequence. Methylation reactions, targeting DNA or histones, represent a large proportion of epigenetic regulations and strongly depend on the availability of methyl donors provided by the ubiquitous one-carbon (1C) metabolism. Thus, understanding the interplay between exposome, 1C metabolism, and epigenetic modifications will likely contribute to elucidating the mechanisms underlying altered gene expression related to ALS and to developing targeted therapeutic interventions. Here, we review evidence for 1C metabolism alterations and epigenetic methylation dysregulations in ALS, with a focus on the impairments reported in neural tissues, and discuss these environmentally driven mechanisms as the consequences of cumulative exposome or late environmental hits, but also as the possible result of early developmental defects.

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Exploring antioxidant strategies in the pathogenesis of ALS

Pinilla-González,

Montecinos-Barrientos,

Martin-Kommer

et al. 2024

Open Life Sciences

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The central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). ALS is a leading cause of motor neuron disease, characterized by a rapidly progressing and incurable condition. ALS often results in death from respiratory failure within 3–5 years from the onset of the first symptoms, underscoring the urgent need to address this medical challenge. The aim of this study is to present available data supporting the role of oxidative stress in the mechanisms underlying ALS and to discuss potential antioxidant therapies currently in development. These therapies aim to improve the quality of life and life expectancy for patients affected by this devastating disease.

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Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis

Cited by 4 publications

References 74 publications

Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis

Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis

From Environment to Gene Expression: Epigenetic Methylations and One-Carbon Metabolism in Amyotrophic Lateral Sclerosis

Exploring antioxidant strategies in the pathogenesis of ALS

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