Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma

Abstract

A higher intake of green leafy vegetables and cruciferous vegetables is associated with a lower risk of NHL overall, particularly follicular lymphoma and DLBCL.

Prediagnostic circulating carotenoid levels and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort

“…Previous studies, in agreement with our findings in blood, have reported inverse associations for individual carotenoids estimated from FFQs, 9,10,[12][13][14]18,21 as well as for carotenoid-rich foods, including green leafy vegetables [9][10][11][12][13][14][15] and yellow-orange vegetables. 9,10,17,20,21 Associations for the intake of fruits in relation to the risk of NHL have been less consistent.…”

“…39,40 Despite our lack of a priori hypothesis and the limited evidence of heterogeneity across common NHL subtypes examined in our analysis, the finding of significant risk estimates primarily confined to DLBCL agrees with several previous reports. [12][13][14]23,24 However, inverse associations with dietary intake of carotenoids have been reported for other NHL subtypes. 11,21 Multiple mechanisms of action for carotenoids in relation to NHL have been proposed.…”

“…4 Based on the hypothesis that lymphoid tissues are vulnerable to nutrient imbalances affecting metabolic pathways and functions necessary to maintain immune functions, 5,6 the association between dietary factors and the risk of NHL has been examined. 7,8 Reports from retrospective case-control studies [9][10][11][12][13][14][15][16][17][18] and prospective cohorts [19][20][21] have found inverse associations between fruit intake, vegetable intake, or both and NHL, although null findings also have been reported. [22][23][24][25][26] Dietary carotenoids are a class of fat-soluble isoprenoid compounds obtained primarily through the consumption of yelloworange fruits and vegetables, green leafy vegetables, and tomatoes; they can function as antioxidants and some function as vitamin A precursors.…”

Dietary and Lifestyle Factors and Risk of Non-Hodgkin's Lymphoma in Oman

“…Our results are consistent with the reported data suggesting that a higher intake of vegetables, in particular the dark green leafy vegetables, may reduce the risk of NHL (Ward et al, 1994;Talamini et al, 2006;Chang et al, 2006;Kelemen et al, 2006;Skibola, 2007;Chiu et al, 2011;Chen et al, 2012). Vegetables are considered as a rich source of carotenoids, vitamins C, E, folate and dietary fiber, as well as numerous other phytochemicals that may inhibit the carcinogenesis by neutralizing the reactive oxygen species generated endogenously or supplied exogenously.…”

Magnesium and lymphoma: opportunities in translation

“…11 In the general population, low magnesium intake predicts the development of NHL. 12 About 60% of patients diagnosed with NHL are aged 65 years and above. Similarly, cytosolic free magnesium concentrations decrease linearly with increasing age.…”