Dietary Intake and Bioavailability of Fluoride

Rao, GS

doi:10.1146/annurev.nu.04.070184.000555

Cited by 76 publications

(13 citation statements)

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“…In some cases distinct areas of hyper or hypo mineralization can be observed on teeth [3,9]. In the worst cases particularly with exposure to elevated levels of fluoride [10] or lead, dark mottled regions are seen.…”

Section: Introductionmentioning

confidence: 99%

Application of laser ablation?inductively coupled plasma-mass spectrometry (LA?ICP?MS) to investigate trace metal spatial distributions in human tooth enamel and dentine growth layers and pulp

Kang

Amarasiriwardena

Goodman

2004

Analytical and Bioanalytical Chemistry

125

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Human tooth enamel provides a nearly permanent and chronological record of an individual's nutritional status and anthropogenic trace metal exposure during development; it might thus provide an excellent bio archive. We investigated the micro-spatial distribution of trace metals (Cu, Fe, Mg, Sr, Pb, and Zn) in 196 x 339 microm2 raster pattern areas (6.6 x 10(4) microm2) in a deciduous tooth using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Ablated areas include prenatal and postnatal enamel, the neonatal line, the dentine-enamel junction (DEJ), dentine, and the dentine-pulp junction. Topographic variations in the surface elemental distribution of lead, zinc, strontium, and iron intensities in a deciduous tooth revealed heterogeneous distribution within and among regions. 43Ca normalized elemental intensities showed the following order: Sr>Mg>>Zn>Pb>Fe>Cu. Elevated zinc and lead levels were present in the dental pulp region and at the neonatal line. This study demonstrates the ability of LA-ICP-MS to provide unique elemental distribution information in micro spatial areas of dental hard tissues. Elemental distribution plots could be useful in decoding nutrition and pollution information embedded in their bio apatite structure.

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Section: Introductionmentioning

confidence: 99%

Application of laser ablation?inductively coupled plasma-mass spectrometry (LA?ICP?MS) to investigate trace metal spatial distributions in human tooth enamel and dentine growth layers and pulp

Kang

Amarasiriwardena

Goodman

2004

Analytical and Bioanalytical Chemistry

125

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“…Dental caries can be prevented by regular brushing and water fluoridation. However, lead may bind to fluoride ions in saliva and plaque, and thereby reduce the ability of fluoride to remineralize enamel after an acid challenge [31]. …”

Section: Discussionmentioning

confidence: 99%

Association between Low blood lead levels and increased risk of dental caries in children: a cross-sectional study

Kim¹,

Kwon

et al. 2017

BMC Oral Health

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BackgroundThe objective of this study was to examine the association between low blood lead levels of <5 μg/dL and the development of dental caries among children.MethodsThe Children’s Health and Environment Research (CHEER) group recruited a cohort of 7,059 school-aged children from six Korean cities. The final study populations in the permanent and deciduous teeth groups were 1,564 and 1,241 children, respectively, after excluding 4 children with blood lead levels of >5 μg/dL. Compared with the children who did not have dental caries, the risk of having dental caries according to blood lead level was estimated by using the zero-inflated negative binomial model.ResultsThe geometric mean (geometric standard deviation, maximum) blood lead level was 1.53 μg/dL (1.57, 4.89 μg/dL), and 74.4% of children had a level of <2 μg/dL. Blood lead level was significantly higher in the children with than in those without deciduous dental caries (1.59 vs. 1.51 μg/dL), similarly with permanent dental caries (1.65 vs. 1.51 μg/dL). After adjustment for covariates, deciduous teeth surfaces that were decayed and filled increased significantly with increasing blood lead levels in a dose-dependent manner (prevalence ratio, 1.14; 95% confidence interval: 1.02–1.27). However, the risk of having dental caries in permanent teeth was not linearly associated with the increase in blood lead level.ConclusionsIn the sum of decayed and filled surfaces, we found a significant increase in risk of dental caries of the deciduous teeth with an increase in blood lead levels (<5 μg/dL) but found no statistical significance in the association with decayed and filled surfaces of caries separately.

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“…Furthermore, fluoridation is not the only source of exposure to fluoride. Research over the years has also indicated another nontrivial source of fluoride exposure through foods (Rao 1984; Rankin et al 2012). Second, as the secondary results demonstrate, diabetes most likely has a multifactorial etiology, even including epigenetic processes.…”

Section: Discussionmentioning

confidence: 99%

Community water fluoridation predicts increase in age-adjusted incidence and prevalence of diabetes in 22 states from 2005 and 2010

Fluegge

2016

Journal of Water and Health

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Community water fluoridation is considered a significant public health achievement of the 20th century. In this paper, the hypothesis that added water fluoridation has contributed to diabetes incidence and prevalence in the United States was investigated. Panel data from publicly available sources were used with population-averaged models to test the associations of added and natural fluoride on the outcomes at the county level in 22 states for the years 2005 and 2010. The findings suggest that a 1 mg increase in the county mean added fluoride significantly positively predicts a 0.23 per 1,000 person increase in age-adjusted diabetes incidence (P < 0.001), and a 0.17% increase in age-adjusted diabetes prevalence percent (P < 0.001), while natural fluoride concentration is significantly protective. For counties using fluorosilicic acid as the chemical additive, both outcomes were lower: by 0.45 per 1,000 persons (P < 0.001) and 0.33% (P < 0.001), respectively. These findings are adjusted for county-level and time-varying changes in per capita tap water consumption, poverty, year, population density, age-adjusted obesity and physical inactivity, and mean number of years since water fluoridation started. Sensitivity analyses revealed robust effects for both types of fluoride. Community water fluoridation is associated with epidemiological outcomes for diabetes.

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Dietary Intake and Bioavailability of Fluoride

Cited by 76 publications

References 0 publications

Application of laser ablation?inductively coupled plasma-mass spectrometry (LA?ICP?MS) to investigate trace metal spatial distributions in human tooth enamel and dentine growth layers and pulp

Application of laser ablation?inductively coupled plasma-mass spectrometry (LA?ICP?MS) to investigate trace metal spatial distributions in human tooth enamel and dentine growth layers and pulp

Association between Low blood lead levels and increased risk of dental caries in children: a cross-sectional study

Community water fluoridation predicts increase in age-adjusted incidence and prevalence of diabetes in 22 states from 2005 and 2010

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