Dietary Intake and Bioavailability of Fluoride

Rao, GS

doi:10.1146/annurev.nutr.4.1.115

Cited by 21 publications

(26 citation statements)

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“…Iron and zinc could also form insoluble complexes with fluoride but the concentration of these chemicals in water and foods is too low to exert significant effect on absorption of fluoride (Feldman et al, 1957;Brudevold et al, 1972). Physiological factors such as age, calcium and parathormone status, renal function etc also influence absorption and retention of fluoride in the body (Rao, 1984). Kidney damage markedly affected the toxicokinetics of fluoride and decreased its elimination in rats (Tomotaro et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of tamarind ingestion on fluoride excretion in humans

Khandare

Rao

2002

Eur J Clin Nutr

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Objective: To evaluate the effect of tamarind (Tamarindus indicus) ingestion on excretion of fluoride in school children. Design: Randomized, diet-control study. Subject: Twenty healthy boys were included and 18 of them completed the study. Interventions: Each subject consumed 10 g tamarind daily with lunch for 18 days at the social welfare boys' hostel. The nutrient composition of the daily diet was constant throughout the experimental period. Results: Tamarind intake led to significant increase (P < 0.001) in the excretion of fluoride in 24 h urine (4.8 AE 0.22 mg=day) as compared to excretion on control diet (3.5 AE 0.22 mg=day). However, excretion of magnesium and zinc decreased significantly (7.11 AE 1.48 mg of Mg and 252.88 AE 12.84 mg of Zn per day on tamarind diet as compared to 23.39 AE 3.68 mg of Mg and 331.78 AE 35.31 mg Zn per day on control diet). Excretion of calcium and phosphorous were not significantly different while creatinine excretion decreased with tamarind intake (225.66 AE 81 mg creatinine=day with tamarind and 294.5 AE 78.76 mg creatinine=day without tamarind). Conclusion: Tamarind intake is likely to help in delaying progression of fluorosis by enhancing urinary excretion of fluoride.

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Section: Discussionmentioning

confidence: 99%

Effect of tamarind ingestion on fluoride excretion in humans

Khandare

Rao

2002

Eur J Clin Nutr

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“…The high temperatures (300° -600° C) used in ashing destroy the organic portion of food to which fluoride may be bound and thereby Adair and Wei (1978) 3 Taves (1983) FLUORIDE CONTENT (~g F/g or ~g F/ml) ACID release the bound fluoride in the free state. Ashing is done in open platinum crucibles, in crucibles covered with tin foil, or in a closed oxygen bomb, the latter method being the most accurate according to Rao (1984).…”

Section: Methodology Of Fluoride Analysismentioning

confidence: 99%

Fluoride Intake of Infants in New Zealand

1990

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“…[3][4][5][6] It is well known that the metabolism and toxicity of F may be modified by a great many factors, including xenobiotics. [7][8][9] Aspirin (2-acetylsalicylic acid, ASA) is the most popular medicine in the world. ASA has been used as an analgesic, anti-inflammatory, and antipyretic substance.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress parameters in rats exposed to fluoride and caffeine

Inkielewicz‐Stępniak

Czarnowski

2010

Food and Chemical Toxicology

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SUMMARY:The action of fluoride (F) and aspirin (acetylsalicylic acid, ASA) administered separately and together on oxidative stress parameters and on F excretion in rats was studied over a period of six weeks. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls receiving tap water; (II) controls receiving intragastrically 1 mL of tap water (once a day); (III) animals receiving 25 mg F/L in their drinking water; (IV) animals receiving 35 mg ASA/kg bw/ day; (V) animals receiving 25 mg F/L in drinking water and 35 mg ASA/kg bw/day. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure time-dependent manner and decreased both in rats treated with ASA and co-exposed to ASA and F. In animals treated with ASA alone, the activity of glutathione peroxidase (GPx) and the concentrations of glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) increased in brain, liver and blood, whereas the activity of catalase (CAT) decreased in liver and erythrocytes, but increased in liver. In rats exposed to F alone the concentration of GSH and the activities of GPx and CAT decreased, whereas the concentration of TBARS significantly increased in liver, brain, kidney and blood. In rats co-exposed to F and ASA, the concentrations of GSH and TBARS and the activities of GPx and CAT (except in liver) were higher than in animals receiving only F.

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Dietary Intake and Bioavailability of Fluoride

Cited by 21 publications

References 0 publications

Effect of tamarind ingestion on fluoride excretion in humans

Effect of tamarind ingestion on fluoride excretion in humans

Fluoride Intake of Infants in New Zealand

Oxidative stress parameters in rats exposed to fluoride and caffeine

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