Dietary Inhibitors of Histone Deacetylases in Intestinal Immunity and Homeostasis

Schilderink, Ronald; Verseijden, Caroline; Jonge, Wouter J. de

doi:10.3389/fimmu.2013.00226

Cited by 69 publications

(77 citation statements)

References 83 publications

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“…Beyond the signaling capacity through GPRs, SCFAs and lactate may also modulate histone deacetylase activity and several modulatory effects on macrophages and epithelial cells were also associated with this capacity (Chang et al, 2014;Latham et al, 2012;Schilderink et al, 2013). Furthermore, high concentrations of lactate in extracellular milieu have also effects on modulation of cell metabolism that can contribute to modulation of proinflammatory mediator production (Dietl et al, 2010), we cannot exclude that some of the effects observed here are related to these latter mechanisms.…”

Section: Discussionmentioning

confidence: 60%

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

et al. 2015

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Section: Discussionmentioning

confidence: 60%

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

et al. 2015

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“…Inhibitory effect of SCFAs, particularly butyrate, on the expression of IL-8 mRNA was evident, resulting in reduction of IL-8 protein in the supernatant, indicating that the mechanism of IL-8 reduction may be mediated through the inhibition of IL-8 gene expression via inhibition of HDAC (Licciardi et al, 2011;Vinolo et al, 2011;Wu et al, 2012;Schilderink et al, 2013). The different effects of SCFAs in normal versus cancerous cells or inflamed cells may be useful in formulation of the more effective drug that inhibit the inflammation, particularly in IBD with stimulate the growth of normal cells and induce apoptosis in cancer cells.…”

Section: Discussionmentioning

confidence: 95%

Short-Chain Fatty Acids Regulate Secretion of IL-8 from Human Intestinal Epithelial Cell Linesin vitro

Asarat

Vasiljevic

Apostolopoulos

et al. 2015

Immunological Investigations

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Short-chain fatty acids (SCFAs) including acetate, propionate and butyrate play an important role in the physiological functions of epithelial cells and colonocytes, such as immune response regulation. Human intestinal epithelial cells (IECs) contribute in intestinal immune response via different ways, such as production of different immune factors including Interleukin (IL) IL-8, which act as chemoattractant for neutrophils, and subsequently enhance inflammation. Therefore, we aimed to evaluate the effects of SCFAs on IECs viability and production of IL-8 in vitro. SCFAs were co-cultured with either normal intestinal epithelial (T4056) or adenocarcinoma derived (HT-29) cell lines for 24-96 h in the presence of E.coli lipopolysaccharides (LPS). Cell viability, proliferation, production of IL-8 and expression of IL-8 mRNA were determined in the cell cultures. The result showed that 20 mM of SCFAs was non-cytotoxic to T4056 and enhanced their growth, whereas the growth of HT-29 was inhibited. The SCFAs down regulated LPS-stimulated IL-8 secretion with different response patterns, but no obvious effects on the release of IL-8 from non LPS- stimulated cells. In conclusion, SCFAs showed regulatory effect on release of LPS-stimulated IL-8 as well as the expression of mRNA of IL-8; these might explain the anti-inflammatory and anti-carcinogenic mechanism of SCFAs.

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“…Further studies will have to determine whether dietary interventions are able to upregulate Tregs during pregnancy and whether this leads to improved fetal health. 39 …”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for Preeclampsia

et al. 2015

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Preeclampsia is a multisystemic syndrome during pregnancy that is often associated with intrauterine growth retardation. Immunologic dysregulation, involving T cells, is implicated in the pathogenesis. The aim of this study was to evaluate the effect of upregulating regulatory T cells in an established transgenic rat model for preeclampsia. Application of superagonistic monoclonal antibody for CD28 has been shown to effectively upregulate regulatory T cells. In the first protocol (treatment protocol), we applied 1 mg of CD28 superagonist or control antibody on days 11 and 15 of pregnancy. In the second protocol (prevention protocol), the superagonist or control antibody was applied on days 1, 5, and 9. Superagonist increased regulatory T cells in circulation and placenta from 8.49±2.09% of CD4-positive T cells to 23.50±3.05% and from 3.85±1.45% to 23.27±7.64%, respectively. Blood pressure and albuminuria (30.6±15.1 versus 14.6±5.5 mg/d) were similar in the superagonist or control antibody–treated preeclamptic group for both protocols. Rats treated with CD28 superagonist showed increased pup weights in the prevention protocol (2.66±0.03 versus 2.37±0.05 g) and in the treatment protocol (3.04±0.04 versus 2.54±0.1 g). Intrauterine growth retardation, calculated by brain:liver weight ratio, was also decreased by the superagonist in both protocols. Further analysis of brain development revealed a 20% increase in brain volume by the superagonist. Induction of regulatory T cells in the circulation and the uteroplacental unit in an established preeclamptic rat model had no influence on maternal hypertension and proteinuria. However, it substantially improved fetal outcome by ameliorating intrauterine growth retardation.

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Dietary Inhibitors of Histone Deacetylases in Intestinal Immunity and Homeostasis

Cited by 69 publications

References 83 publications

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

Short-Chain Fatty Acids Regulate Secretion of IL-8 from Human Intestinal Epithelial Cell Linesin vitro

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for Preeclampsia

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