Dietary ingestion of 2-aminoanthracene (2AA) and the risk for type-1 diabetes (T1D)

Seise, Isaiah; Pilz, Zachary A; Kusi, Moses Yeboah; Bogan, Bethany; McHale, Brittany; Gato, Worlanyo E.

doi:10.1080/10934529.2020.1830651

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…Type 1 diabetes (T1D) is an autoimmune disease mediated by the destruction of insulin-secreting pancreatic β cells [ 125 ]. Exposure to 2-aminoanthracene (2AA), an individual PAH, was recently considered to be one of the factors that increase TID [ 126 ]. T1D development was enhanced by 2AA [ 126 ].…”

Section: How Pahs Influence the Human Bodymentioning

confidence: 99%

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Effect of polycyclic aromatic hydrocarbons on immunity

Jin

2022

Journal of Translational Autoimmunity

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Section: How Pahs Influence the Human Bodymentioning

confidence: 99%

“…Exposure to 2-aminoanthracene (2AA), an individual PAH, was recently considered to be one of the factors that increase TID [ 126 ]. T1D development was enhanced by 2AA [ 126 ]. O'Driscoll concluded in his review that PM exposure may upregulate the incidence of T1D in children and worsen diabetes in adults [ 57 ].…”

Section: How Pahs Influence the Human Bodymentioning

confidence: 99%

Effect of polycyclic aromatic hydrocarbons on immunity

Jin

2022

Journal of Translational Autoimmunity

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“…Indeed, levels of nine monohydroxylated urinary PAH metabolites as well as the interaction between PAH exposure and smoking have been found to positively correlate with the prevalence of late-stage rheumatoid arthritis [ 16 ]. Exposure to 2-aminoanthracene (2AA), a PAH, was shown to increase the risk for type 1 diabetes [ 17 ]. PM 10 concentration was linked to multiple sclerosis severity in both human and animal studies [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

Zhu

Kennicott

Liang

2023

IJMS

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Studies indicate that genetic factors only account for approximately thirty percent of all autoimmune diseases, while the rest of autoimmune pathogenesis is attributed to environmental factors including toxic chemicals. To understand if and how environmental pollutants trigger autoimmunity, we investigated the effect of benzo[a]pyrene (BaP) exposure on the development of autoimmune phenotypes in the lupus-prone MRL strain. The exposure of MRL mice to BaP over the course of 8 weeks before lupus onset resulted in total body weight loss in males, while marginal changes in anti-dsDNA levels occurred. Multi-organ analyses of BaP-treated and control MRL mice suggested that the kidney is a major organ directly affected by the metabolism of benzene-containing compounds, with increased expression of BaP-target genes including Cyp4b1 and Hao2. Intriguingly, spatial transcriptomic data showed that BaP caused a drastic reduction in cell-type diversity in both the kidneys and spleen of MRL mice. Further analysis of the molecular pathways affected suggested a sex-biased effect of BaP treatment, with the upregulated expression of angiogenesis genes in the lungs and an increased deposition of C3 in the kidneys of male mice. While SLE is more common in women, the disease is more severe in male patients, with an increased risk of disease progression to renal failure and lung cancer. Our results reveal sex-biased molecular pathways stimulated by BaP which may help explain the increased likelihood of end organ damage in males with lupus.

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Dietary ingestion of 2-aminoanthracene (2AA) and the risk for type-1 diabetes (T1D)

Cited by 2 publications

References 20 publications

Effect of polycyclic aromatic hydrocarbons on immunity

Effect of polycyclic aromatic hydrocarbons on immunity

Benzo[a]pyrene Exposure Reduces Cell-Type Diversity and Stimulates Sex-Biased Damage Pathways in End Organs of Lupus-Prone Mice

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