Dietary influence on adiponectin in patients with type 2 diabetes

Bozzetto, Lutgarda; Polito, Rita; Nigro, Ersilia; Prinster, Anna; Pepa, Giuseppe Della; Costabile, Giuseppina; Vetrani, Claudia; Vitale, Marilena; Daniele, Aurora; Rivellese, Angela Albarosa; Annuzzi, Giovanni

doi:10.1111/eci.13548

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Havel et al hypothesized that greater intake of fat might lower leptin concentration whereas a low fat/high carb diet induces higher levels of leptin. Rodent models have shown an effect of dietary fatty acids on serum adiponectin indicating lower levels of adiponectin in high fat diet supporting our results, but clinical data did not confirm the results [ 54 , 55 ].…”

Section: Discussioncontrasting

confidence: 54%

Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants

Lederer

Storz

Huber

et al. 2022

IJERPH

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Adiponectin and leptin are important mediators of metabolic homeostasis. The actions of these adipokines extend beyond adipocytes and include systemic modulation of lipid and glucose metabolism, nutrient flux, and the immune response to changes in nutrition. Herein, we hypothesized that short-term intervention with a vegan diet might result in an improvement of plasma concentrations of adiponectin and leptin and the leptin/adiponectin ratio. We investigated the response of plasma adiponectin and leptin to a 4-week intervention with a vegan or meat-rich diet and its associations with sex, BMI and nutritional intake. Fifty-three healthy, omnivore participants (62% female, average age 31 years and BMI 23.1 kg/m2) were randomly assigned to a vegan or meat-rich diet for 4 weeks. Plasma adiponectin and leptin were lower in men compared to women both at the beginning and end of the trial. The concentration of adiponectin in women was significantly higher both when comparing their transition from omnivorous to vegan diet (p = 0.023) and also for vegan versus meat-rich diet at the end of the trial (p = 0.001), whereas plasma leptin did not vary significantly. No changes in adiponectin were identified in men, yet an increase in leptin occurred upon their transition from an omnivorous to a meat-rich diet (p = 0.019). Examination of plasma adiponectin/leptin ratio, a proposed marker of cardiovascular risk, did not differ after 4-weeks of dietary intervention. Our study revealed that adiponectin and leptin concentrations are sensitive to short-term dietary intervention in a sex-dependent manner. This dietary modification of leptin and adiponectin not only occurs quickly as demonstrated in our study, but it remains such as published in studies with individuals who are established (long-term) vegetarians compared to omnivorous.

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Section: Discussioncontrasting

confidence: 54%

Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants

Lederer

Storz

Huber

et al. 2022

IJERPH

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show abstract

“…Second, the concentration of these adipokines might affected by some factors such as diet, exercise, age, and gender. 44 , 45 Besides, the adipokines are derived from the adipose tissues so that the secretion might depend on the BMI and fat mass volume. In this research, we did not estimate the red blood cell span, which is one of the most impacting factors on HbA1c results.…”

Section: Discussionmentioning

confidence: 99%

The Plasma Levels of Protein Adiponectin (AdipoQ) and Meteorin-Like (Metrnl) in Newly Diagnosed Type 2 Diabetes Mellitus

Phuong,

Tran Huy,

Huynh Quang

2024

DMSO

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Purpose This study aimed to measure the concentrations of the Adiponectin and Meteorin – Like (Metrnl) in newly diagnosed type 2 diabetes patients. Patients and Methods A comparative cross-sectional study contained two groups: Group 1 (86 newly diagnosed diabetes mellitus type 2 patients) and group 2 (71 healthy persons). The plasma concentrations of Adiponectin and Metrnl were measured by Enzyme Link Immunosorbent Assay (ELISA). Results The plasma level of Adiponectin of the newly diagnosed diabetes mellitus type 2 group and the healthy group were 1219.82 ng/mL ( 1132.43–2772.50 ) and 1187.25 ng/mL ( 1160.66–3807.50 ) respectively. The plasma level of Metrnl of two groups were 757.60 pg/mL ( 564.15–994.00 ) and 697.60 pg/mL ( 538.50–986.10 ) respectively. There were no significant difference between two groups. Metrnl had no correlation with glucose, HbA1c, lipid profile, BMI. Adiponectin had correlation with Metrnl and HDL-cholesterol. Adiponectin had no correlation to glucose, HbA1c, LDL-cholesterol, total cholesterol, triglyceride, BMI. People with the lower Adiponectin concentration had the higher risk of diabetes (OR=6.52; 95% CI: 2.43 −17.55). Conclusion Adiponectin and Metrnl were not significantly different in newly diagnosed type 2 diabetes and healthy people. The lower concentration of Adiponectin might increase the risk of type 2 diabetes.

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The Role of Adipose Tissue and Nutrition in the Regulation of Adiponectin

Baldelli,

Aiello,

Mansilla Di Martino

et al. 2024

Nutrients

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Adipose tissue (AT), composed mainly of adipocytes, plays a critical role in lipid control, metabolism, and energy storage. Once considered metabolically inert, AT is now recognized as a dynamic endocrine organ that regulates food intake, energy homeostasis, insulin sensitivity, thermoregulation, and immune responses. This review examines the multifaceted role of adiponectin, a predominant adipokine released by AT, in glucose and fatty acid metabolism. We explore the regulatory mechanisms of adiponectin, its physiological effects and its potential as a therapeutic target for metabolic diseases such as type 2 diabetes, cardiovascular disease and fatty liver disease. Furthermore, we analyze the impact of various dietary patterns, specific nutrients, and physical activities on adiponectin levels, highlighting strategies to improve metabolic health. Our comprehensive review provides insights into the critical functions of adiponectin and its importance in maintaining systemic metabolic homeostasis.

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Dietary influence on adiponectin in patients with type 2 diabetes

Cited by 3 publications

References 31 publications

Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants

Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants

The Plasma Levels of Protein Adiponectin (AdipoQ) and Meteorin-Like (Metrnl) in Newly Diagnosed Type 2 Diabetes Mellitus

The Role of Adipose Tissue and Nutrition in the Regulation of Adiponectin

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