Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross‐sectional analysis

Syrjäläinen, Sanna; Männistö, Satu; Könönen, Eija; Pussinen, Pirkko; Gürsoy, Mervi; Suominen, Anna Liisa; Jousilahti, Pekka; Gürsoy, Ulvi Kahraman

doi:10.1111/jcpe.13917

Cited by 2 publications

(1 citation statement)

References 55 publications

(90 reference statements)

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“…Various diets were found to be associated with periodontitis in different ways, highlighting the significant impact of nutrition on oral health. One study has found a latent correlation between diet and periodontitis, with their interconnection established through factors beyond diet-dependent inflammatory propensities (Syrjäläinen et al, 2023). For example, vegetarians, compared to non-vegetarians, have lower periodontal pocket depth (PPD) and less gingival bleeding (Staufenbiel et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Yang,

Wang,

Hong

et al. 2024

Front. Genet.

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BackgroundPeriodontitis, a complex inflammatory condition, has been associated with dietary habits and antioxidants. While the association between certain dietary patterns and periodontitis has been documented, the bidirectional relationship remains unclear. This study utilizes Mendelian randomization (MR) analysis to investigate the bidirectional associations between dietary factors comprising dietary antioxidants, and periodontitis.MethodsEmploying a two-sample MR approach, this study analyzed genome-wide association study (GWAS) data on diets and periodontitis from large databases and published literature. Instrumental variables (IVs) were selected and filtered based on genetic variants associated with dietary factors and periodontitis, respectively. Various MR methods, including Inverse Variance Weighted, MR-Egger, Weighted Median, Weighted Mode, and Simple Mode were applied to assess the bidirectional associations. Sensitivity analyses were conducted to validate the robustness of the findings.ResultsOur analysis revealed significant associations between certain dietary factors and the risk of periodontitis. Specifically, higher intake of filtered coffee, low-calorie drinks, and other cereals, as well as increased metabolic circulating levels of gamma-tocopherol, were associated with an elevated risk of periodontitis. Conversely, consumption of cheese, white rice, chocolate bars, unsalted peanuts, and higher absolute circulating levels of vitamin C were linked to a reduced risk. Additionally, the study suggests that periodontitis may influence dietary habits, indicating a bidirectional relationship.ConclusionThis study provides additional evidence of a bidirectional association between dietary factors and periodontitis. It highlights the importance of dietary interventions in the prevention and management of periodontitis. The findings underscore the need for incorporating dietary counseling into periodontal disease management protocols and suggest the potential of personalized dietary strategies for periodontitis patients. Further research is warranted to explore the mechanisms underlying these associations and to confirm these findings in diverse populations.

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Section: Introductionmentioning

confidence: 99%

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Yang,

Wang,

Hong

et al. 2024

Front. Genet.

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Interleukin-6 Receptor Gene rs1800795 Polymorphism and Expression of Interleukin-6 in Gingival Tissue in Patients with Periodontitis

Mazurek-Mochol,

Bonsmann,

Malinowski

et al. 2024

Microorganisms

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Periodontitis is a multifactorial inflammatory disease. This chronic periodontal disease is caused by a bacterial infection in the gums, which triggers a host inflammatory response. To eliminate the bacterial infection, immune response mechanisms are activated, leading to inflammation and damage to the periodontal tissues. This process involves many cytokines, including IL-6, a cytokine with antibacterial properties. An ongoing bacterial infection in the periodontal tissues leads to its excessive production, which increases inflammation. In this study, we examined IL-6 receptor gene rs1800795 polymorphism in patients with periodontitis in comparison with healthy subjects, as well as the correlation between rs1800795 genotypes and clinical parameters. Additionally we examined the expression of IL-6 in gingival tissue in patients with periodontitis and control subjects, as well as the correlation between gingival expression of IL-6 and clinical parameters. This study included 200 patients with periodontitis and 158 healthy subjects as the control group. Biopsy specimens of gingival tissue in which IL-6 expression was detected were taken from 14 patients with periodontitis and 8 controls who had undergone minor surgery. There were no statistically significant differences in the distribution of IL-6 rs1800795 genotypes and alleles between patients with periodontitis and control subjects. There were also no statistically significant correlations between IL-6 rs1800795 genotypes and clinical parameters in patients with periodontitis. There were no differences in IL-6 expression in the gingival tissue between patients with periodontitis and controls. There was also no correlation between IL-6 expression in the gingival tissue of patients with periodontitis and clinical parameters. In the control group, IL-6 expression in gingival tissue correlated negatively with the approximal plaque index, which reflects the size of bacterial plaques. The results of our study suggest a protective role for IL-6 against bacterial growth in the periodontal tissue. However, it should be noted that several parameters directly or indirectly affect the accumulation of bacterial plaque.

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Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross‐sectional analysis

Cited by 2 publications

References 55 publications

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

Interleukin-6 Receptor Gene rs1800795 Polymorphism and Expression of Interleukin-6 in Gingival Tissue in Patients with Periodontitis

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