Dietary inflammatory index and incidence of breast cancer in the SUN project

Gardeazabal, Itziar; Ruiz‐Canela, Miguel; Sánchez-Bayona, Rodrigo; Romanos-Nanclares, Andrea; Beitia, José Manuel Aramendía; Shivappa, Nitin; Hébert, James R.; Martínez-González, M Á; Toledo, Estefanía

doi:10.1016/j.clnu.2018.09.030

Cited by 21 publications

(22 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, in the prospective Swedish Women’s Lifestyle Study there was about a 20% increase in being diagnosed with breast cancer across extreme DII quartiles (HR DIIquartile4vs1 = 1.18; 95% CI: 1.00–1.39), with somewhat stronger associations in postmenopausal women (HR DIIquartile4vs1 =1.22; 95% CI: 1.01–1.46) [139]. In addition, we have observed null results in some studies [81,144,145]. Results from studies in the US and Italy focusing on breast cancer survival have been consistently positive [146,147,148].…”

Section: DII and Cancersmentioning

confidence: 81%

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

et al. 2019

View full text Add to dashboard Cite

There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.

show abstract

Section: DII and Cancersmentioning

confidence: 81%

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The development and progression of BC has been linked, among other parameters, to inflammation [55]. The evidence regarding the association between DII and overall BC risk is still inconclusive despite being evaluated in several prospective cohorts [31,32,56,57,58], case-control studies [59,60,61,62,63], and cancer-specific and general meta-analyses [30,64,65,66]. Although our estimates suggested increased relative risks for the association between E-DII and overall BC, the 95% CIs included the null value.…”

Section: Discussionmentioning

confidence: 99%

Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)

et al. 2019

View full text Add to dashboard Cite

Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.

show abstract

“…Recently, the dietary inflammatory index (DII) [18,19] has been developed to reflect inflammatory potential of the diet and scores an individual's diet on a continuum from anti to pro-inflammatory [20]. The DII has been shown to be associated with diseases such as diabetes [21], obesity [22], asthma [23], cancer [24,25], myocardial infarction, stroke and CVD mortality [26][27][28]. Some prior studies have prospectively assessed the inflammatory potential of the diet in relation to hypertension or blood pressure [29,30], both finding a positive association between the DII and hypertension diagnosis, or blood pressure increases, but did not report the shape of the association.…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

MacDonald

Laouali

Madika

et al. 2020

Nutr J

View full text Add to dashboard Cite

Introduction: Previous studies have identified a positive association between the inflammatory potential of the diet and hypertension. It is not known if BMI is an effect modifier for this association, nor if the association is doserespondent. This study aimed to assess the association between the dietary inflammatory index (DII) and the risk of hypertension, and assess any effect modification from BMI. Methods: Data from the E3N cohort study, a French prospective population-based study initiated in 1990 was used. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,652 women. The adapted DII was assessed with data from the dietary questionnaire. Hypertension cases were self-reported and verified through a drug-reimbursement database. Cox proportional hazard models were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship. Results: During 884,267 person-years, 13,183 cases of incident hypertension were identified. The median DII in the population was slightly pro-inflammatory (DII = + 0.44). A highly pro-inflammatory diet (DII > 3.0) was associated with a slight increase in hypertension risk (HR Q1-Q5 = 1.07 [1.02, 1.13]). Evidence was observed for effect modification from BMI, with associations strongest amongst women in the 18.5-21.0 BMI range (HR Q1-Q5 = 1.17 [1.06, 1.29]). A weak dose-respondent relationship was observed. Conclusion: Evidence for a weak association between DII and hypertension was observed. Associations were stronger amongst healthy-lean women.

show abstract

Dietary inflammatory index and incidence of breast cancer in the SUN project

Cited by 21 publications

References 60 publications

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)

Dietary inflammatory index, risk of incident hypertension, and effect modification from BMI

Contact Info

Product

Resources

About