Dietary inclusion of glucose oxidase supplementation to
                    corn-wheat-based diet enhance growth performance, nutrient digestibility, blood
                    profile of lactating sows

Shanmugam, Subbiah; Liu, Yanjie; Chen, Ning Bo; Kim, In Ho

doi:10.5187/jast.2021.e66

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Previous study found that 120 mg/kg macleaya extract (a standardized premixture of MCE) increased weight gain and nutrient digestibility of piglets (23). Sureshkumar et al reported that the ADG were significantly increased in piglets fed diet supplemented with 400 U/kg glucose oxidase (24). In the present study, MCE and GOD compound additives significantly increased ADG and decreased F/G, but did not change ADFI in piglets.…”

Section: Discussionsupporting

confidence: 54%

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

Chen,

Zhang,

et al. 2023

Front. Vet. Sci.

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This study aims to investigate the effects of macleaya extract and glucose oxidase combination (MGO) on growth performance, antioxidant capacity, immune function, and cecal microbiota in piglets. A total of 120 healthy 28-day-old weaned piglets were randomly divided into two treatments of six replicates. Piglets were either received a basal diet or a basal diet supplemented with 250 mg/kg MGO (2 g/kg sanguinarine, 1 g/kg chelerythrine, and 1 × 106 U/kg glucose oxidase). The results showed that MGO supplementation increased average daily gain (ADG) and decreased feed:gain ratio (F/G) (p < 0.05). MGO increased serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and immunoglobulin G (IgG) content (p < 0.05), but decreased malondialdehyde (MDA) and interleukin 1β (IL-1β) content (p < 0.05). The jejunal mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione peroxidase 1 (GPX1), and heme oxygenase 1 (HO-1) were increased in MGO group (p < 0.05), while that of kelch like ECH associated protein 1 (Keap1) was decreased (p < 0.05). The Firmicutes was significantly increased at phylum levels in MGO group (p < 0.05). In conclusion, 250 mg/kg MGO improved piglet growth, and regulated intestinal flora of piglets, which provided a theoretical basis for MGO as an alternative additive for antibiotics.

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Section: Discussionsupporting

confidence: 54%

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

Chen,

Zhang,

et al. 2023

Front. Vet. Sci.

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“…This inconsistency might result from the differences in pathogen serotype and dosage or the number of times oral ETEC administration. Previously, supplemental GOD was indicated to improve growth performance in pigs under non-infection conditions ( Tang et al, 2016 ; Dang et al, 2021 ; Sureshkumar et al, 2021 ). However, it is unknown whether GOD could protect piglet growth against infection.…”

Section: Discussionmentioning

confidence: 99%

“…(3) Generation of hydrogen peroxide catalyzed by GOD is favorable for defending against bacterial invasion due to its broad-spectrum antibacterial effect (Murphy and Friedman, 2019). Previously, several studies have validated the positive effects of GOD addition on growth performance and gut health in chickens (Wu et al, 2019(Wu et al, , 2020Meng et al, 2021) and pigs (Tang et al, 2016;Dang et al, 2021;Sureshkumar et al, 2021) under the non-challenge condition. Moreover, GOD might be profitable for guarding against bacterial infection, as supported by the study of Zhao et al (2022) who observed that GOD addition attenuated Clostridium perfringens-induced necrotic enteritis of broilers by improving intestinal structure and functions.…”

Section: Introductionmentioning

confidence: 99%

Effects of glucose oxidase on growth performance, clinical symptoms, serum parameters, and intestinal health in piglets challenged by enterotoxigenic Escherichia coli

et al. 2022

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Glucose oxidase (GOD) could benefit intestinal health and growth performance in animals. However, it is unknown whether GOD can protect piglets against bacterial challenge. This study aimed to evaluate the protective effects of GOD on growth performance, clinical symptoms, serum parameters, and intestinal health in piglets challenged by enterotoxigenic Escherichia coli (ETEC). A total of 44 male weaned piglets around 38 days old were divided into four groups (11 replicates/group): negative control (NC), positive control (PC), CS group (PC piglets +40 g/t colistin sulfate), and GOD group (PC piglets +200 g/t GOD). All piglets except those in NC were challenged with ETEC (E. coli K88) on the 11th day of the experiment. Parameter analysis was performed on the 21st day of the experiment. The results showed that the ETEC challenge elevated (p < 0.05) the rectal temperature and fecal score of piglets at certain time-points post-challenge, reduced (p < 0.05) serum glucose and IgG levels but increased (p < 0.05) serum alanine aminotransferase activity, as well as caused (p < 0.05) intestinal morphology impairment and inflammation. Supplemental GOD could replace CS to reverse (p < 0.05) the above changes and tended to increase (p = 0.099) average daily gain during the ETEC challenge. Besides, GOD addition reversed ETEC-induced losses (p < 0.05) in several beneficial bacteria (e.g., Lactobacillus salivarius) along with increases (p < 0.05) in certain harmful bacteria (e.g., Enterobacteriaceae and Escherichia/Shigella). Functional prediction of gut microbiota revealed that ETEC-induced upregulations (p < 0.05) of certain pathogenicity-related pathways (e.g., bacterial invasion of epithelial cells and shigellosis) were blocked by GOD addition, which also normalized the observed downregulations (p < 0.05) of bacterial pathways related to the metabolism of sugars, functional amino acids, nucleobases, and bile acids in challenged piglets. Collectively, GOD could be used as a potential antibiotic alternative to improve growth and serum parameters, as well as attenuate clinical symptoms and intestinal disruption in ETEC-challenged piglets, which could be associated with its ability to mitigate gut microbiota dysbiosis. Our findings provided evidence for the usage of GOD as an approach to restrict ETEC infection in pigs.

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“…4 Body weight difference: Initial to Farrowing; 2, Farrowing to Weaning; 3, Weaning to Ovulation. 5 Backfat thickness difference: Initial to Farrowing; 2, Farrowing to Weaning; 3, Weaning to Ovulation. ADFI, average daily feed intake.…”

Section: Reproduction Performance Of Sowsmentioning

confidence: 99%

“…Intestinal health is the basis for overall pig health, maximum growth performance, and feed utilization efficiency [ 4 ]. However, after sow pregnancy, piglets’ feed intake is usually limited due to insufficient milk production when the sow responds to various stress factors [ 5 ]. The intestines of piglets atrophy and induce intestinal oxidative stress, and the deficiency of various nutrients, including glutamate, leads to a related growth depression syndrome in piglets [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Supplementing Monosodium Glutamate in Sow Diets Enhances Reproductive Performance in Lactating Sows and Improves the Growth of Suckling Piglets

Li,

Kim

2024

Animals

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In most current farm operations, lactating sows need to overcome reproductive and environmental stresses that have resulted in poor sow production performance and piglet growth. Therefore, this study aimed to investigate the effects of in-feed supplementation of monosodium glutamate (MSG) in sows during late gestation lactation in regard to litter performance. The study subjects were 12 multi-parity sows (Landrace × Large White), farrowing sows with an average parity of four (three with three parities, seven with four parities, and two with five parities). They were randomly divided into the following two diet groups: the basal diet as a control (CON) group based on corn and soybean meal; and the basal diet + 2% MSG group. The experimental time ranged from 109 days before delivery to 21 days after delivery. There were six sows in each group, and each sow served as the experimental unit. There were no significant differences (p > 0.05) in body weight (BW), back fat (BF) thickness and estrus interval between sows supplemented with 2% MSG in their diets before and after farrowing and during weaning (p > 0.05). However, MSG-treated sows tended to increase BW loss at farrowing more than the CON group (p = 0.093) but lost less weight during lactation than the CON group (p = 0.019). There were no significant differences in the body condition scores (BCSs) and BF loss of the two groups of sows before and after farrowing and at weaning (p > 0.05). There was no significant difference in the weight of newborn piglets between the two groups of sows (p > 0.05). The weaning weight (p = 0.020) and average daily gain (ADG) (p = 0.045) of suckling piglets were higher in the MSG treated group compared to the CON group. The daily milk production of sows in the MSG treatment group was higher compared to the CON group (p = 0.045). The protein concentration of milk at week 3 (p = 0.060) and fat concentration of milk at week 5 (p = 0.095) of the MSG-supplemented sows tended to increase more than the CON group. In summary, the dietary inclusion of MSG supplementation had a beneficial effect on the late gestating sows and their piglet’s growth and milk production. Our research has shown that the addition of 2% MSG in late gestation and lactation diet would be beneficial for both sow and piglet production.

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Dietary inclusion of glucose oxidase supplementation to corn-wheat-based diet enhance growth performance, nutrient digestibility, blood profile of lactating sows

Abstract: Dietary inclusion of glucose oxidase supplementation to corn-wheatbased diet enhance growth performance, nutrient digestibility, blood profile of lactating sows Running Title (within 10 words)Effect of glucose oxidase on lactating sows

Cited by 7 publications

References 44 publications

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

The combination of macleaya extract and glucose oxidase improves the growth performance, antioxidant capacity, immune function and cecal microbiota of piglets

Effects of glucose oxidase on growth performance, clinical symptoms, serum parameters, and intestinal health in piglets challenged by enterotoxigenic Escherichia coli

Supplementing Monosodium Glutamate in Sow Diets Enhances Reproductive Performance in Lactating Sows and Improves the Growth of Suckling Piglets

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