Dietary immunostimulants reduced infectivity of Diplostomum spp. eye fluke in common carp, Cyprinus carpio L

Chupani, Latifeh; Erasmus, Bernard; Soldánová, Miroslava; Zusková, Eliška

doi:10.1016/j.fsi.2021.10.035

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…As far as the mechanism is concerned, enrofloxacin mainly exerts its bactericidal effect by interfering with bacterial DNA replication and rupturing the cell membrane [55,56]. The combined immunostimulant of β-glucan and APS effectively removes pathogens by activating the host immune system [57,58]. In addition, histopathological sections provide a direct reflection of tissue damage after bacterial infection [59].…”

Section: Discussionmentioning

confidence: 99%

The Combination of β-Glucan and Astragalus Polysaccharide Effectively Resists Nocardia seriolae Infection in Largemouth Bass (Micropterus salmoides)

Zhao,

Huo,

Wang

et al. 2023

Microorganisms

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Effectively treating and preventing outbreaks is crucial for improving the economic benefits of aquaculture. Therefore, utilizing immunostimulants, either alone or in combination, is regarded as a promising strategy. In this study, β-glucan + APS (200 mg/kg + 200 mg/kg), β-glucan (200 mg/kg), APS (200 mg/kg), enrofloxacin (15 mg/kg), and sulfadiazine (15 mg/kg) were added to feed to assess the effects against Nocardia seriolae infection in largemouth bass (Micropterus salmoides) within 14 days. The survival rates did not differ between the enrofloxacin group and the β-glucan + APS group, but both were significantly higher than that of the control group. Additionally, the enrofloxacin group and the β-glucan + APS group exhibited the lowest bacterial loads and tissue damage. Importantly, the β-glucan + APS treatment significantly improved serum enzyme activities (total superoxide dismutase, lysozyme, total protein) and the expression of immune genes (IL-1β, TNF-α, IFN-γ, IgM) compared to the other treatment groups. The enrofloxacin group showed similar efficacy to the β-glucan + APS group in combating N. seriolae infection, but N. seriolae in the enrofloxacin group developed drug resistance. In summary, the combined use of β-glucan and APS is a promising strategy for treating bacterial diseases, thereby contributing to the promotion of sustainable aquaculture development.

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Section: Discussionmentioning

confidence: 99%

The Combination of β-Glucan and Astragalus Polysaccharide Effectively Resists Nocardia seriolae Infection in Largemouth Bass (Micropterus salmoides)

Zhao,

Huo,

Wang

et al. 2023

Microorganisms

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“…Correspondingly, Diplostomum could be affected differently.However, involvement of at least a partial role of the mucous surfaces, with regard to eye flukes, cannot be excluded as these factors were affected in e.g. common carp by feeding beta-glucan, nucleotides or chitosan which reduced the susceptibility to Diplostomum [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Responses towards eyefluke (Diplostomum pseudospathaceum) in different genetic lineages of rainbow trout

Karami

Duan²,

Kania³

et al. 2022

PLoS ONE

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Marker-assisted selective breeding of fish with higher levels of resistance towards specific pathogens may improve fish health, but the impact of host genotype on susceptibility to multiple pathogen infections is still poorly investigated. This study examined the resistance in rainbow trout Oncorhynchus mykiss towards infection with the eye fluke Diplostomum pseudospathaceum. We used genetically selected rainbow trout, carrying SNPs associated with resistance towards the parasitic ciliate Ichthyophthirius multifiliis, and exposed the fish to eye fluke cercariae. We showed that fish partly resistant to I. multifiliis were more susceptible to eye fluke invasion. The expression of immune relevant genes (encoding innate and adaptive factors) was also affected as these genotypes responded less strongly to a secondary fluke infection. The complexity of genome architecture in disease resistance towards multiple pathogens is discussed.

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“…In the past, antibiotics have been used as the first drug choice to ensure fish health in aquaculture choice, but this has also brought huge negative effects (generation of drug-resistant bacteria, organism residues, and so on) [5]. Therefore, the main point of research has now shifted to more ecological approaches, including the use of immunostimulants to potentially increase disease resistance in fish [6]. Immunostimulants are a class of chemical compounds that activate leukocytes and can trigger nonspecific and specific defense systems of fish, which make fish more resistant to viral, bacterial, fungal, and parasitic infections [7,8].…”

Section: Introductionmentioning

confidence: 99%

Isalo scorpion cytotoxic peptide‐strengthened immune function through the JAKs/STATs signaling pathway of the immune organ of grass carp (Ctenopharyngodon idella) challenged with Aeromonas hydrophila

He,

Hu,

Zhou

et al. 2024

Animal Research and One Health

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To investigate the impact of Isalo scorpion cytotoxic peptide (IsCT) on the immune function of immune organ (head kidney, spleen, and skin) of grass carp (Ctenopharyngodon idella), 540 fish (136.88 ± 0.72 g) were supplied with a different amount of IsCT (0, 0.6, 1.2, 1.8, 2.4, and 3.0 mg/kg diet) through a period of 60 days. Afterward, 24 fish were randomly selected from each group and were inoculated with Aeromonas hydrophila for a period of 6 days. Our findings suggested that appropriate IsCT complementation: (1) attenuated skin morbidity and histopathological structural changes in the head kidney and spleen (p < 0.05), which ensured the structural integrity of the immune organs; (2) increased the activity and expression of immune substances (p < 0.05), which in turn increased the function of the immune organs, promoting immune responses; (3) through the regulation of the Janus kinase/signal transducers and activators of transcription (JAKs/STATs) signaling pathway, the mRNA expression of anti‐inflammatory cytokines increased and the mRNA expression of pro‐inflammatory cytokines decreased, which in turn increased the function of the immune organs, reducing the inflammatory response (p < 0.05). However, the addition of IsCT did not affect the expression of IL‐12p35, STAT2, and STAT3a in the immune organ. Ultimately, this study provided evidence that IsCT enhanced immune function via the JAKs/STATs signaling pathway in the immune organ in grass carp after challenged with Aeromonas hydrophila.

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Dietary immunostimulants reduced infectivity of Diplostomum spp. eye fluke in common carp, Cyprinus carpio L

Cited by 6 publications

References 18 publications

The Combination of β-Glucan and Astragalus Polysaccharide Effectively Resists Nocardia seriolae Infection in Largemouth Bass (Micropterus salmoides)

The Combination of β-Glucan and Astragalus Polysaccharide Effectively Resists Nocardia seriolae Infection in Largemouth Bass (Micropterus salmoides)

Responses towards eyefluke (Diplostomum pseudospathaceum) in different genetic lineages of rainbow trout

Isalo scorpion cytotoxic peptide‐strengthened immune function through the JAKs/STATs signaling pathway of the immune organ of grass carp (Ctenopharyngodon idella) challenged with Aeromonas hydrophila

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