Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Barichella, Michela; Cereda, Emanuele; Cassani, E.; Pinelli, Giovanna; Iorio, Laura; Ferri, Valentina; Privitera, Giulia; Pasqua, M.; Valentino, Angela; Monajemi, F; Caronni, Serena; Lignola, Caterina; Pusani, C.; Bolliri, Carlotta; Faierman, S.A.; Lubisco, Alessandro; Frazzitta, Giuseppe; Petroni, Maria Letizia; Pezzoli, Gianni

doi:10.1016/j.clnu.2016.06.020

Cited by 79 publications

(93 citation statements)

References 44 publications

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“…Nevertheless, Barichella et al recently performed a large observational study in 510 parkinsonians on levodopa therapy, and compared the motor function and levodopa dosage of 277 patients who adhered to PRD and 233 patients who did not. This study revealed that the patients following PRD indeed experienced a significantly improved “off” score by Unified Parkinson Disease Rating Scale (UPDRS)-Part IV as well as a markedly decreased levodopa dosage (Barichella et al, 2016a). The inverse relation between PRD and motor fluctuaions was furtherly confirmed via multivariate regression analysis including gender, age of onset, duration of PD and dosage of levodopa.…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 97%

“…The inverse relation between PRD and motor fluctuaions was furtherly confirmed via multivariate regression analysis including gender, age of onset, duration of PD and dosage of levodopa. (Barichella et al, 2016a). The study also found that an excess of protein intake by 10 g over RDA was corresponded to an increase in levodopa dosage by 0.7 mg/kg/day, confirming the negative correlation between protein intake and therapeuatic efficiency of levodopa (Barichella et al, 2016a).…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 98%

“…(Barichella et al, 2016a). The study also found that an excess of protein intake by 10 g over RDA was corresponded to an increase in levodopa dosage by 0.7 mg/kg/day, confirming the negative correlation between protein intake and therapeuatic efficiency of levodopa (Barichella et al, 2016a). Regrettably, the major limitation of this study is a cross-sectional design which lacks information about the duration of PRD in 277 adherents.…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

“…Likewise, Carter et al reported the mean AIMS dyskinesia score of 5 patients with marked fluctuations increased by 1.9 points during a LPD (0.9 vs. 2.8 points), and increased by 2.5 points during a PRD (0.9 vs. 3.4 points; Carter et al, 1989). By comparing the observational data of 277 PRD adherents and 233 controls, Barichella et al found that the patients receiving a PRD got a higher mean dyskinesia score by UPDRS-Part IV compared with those who did not follow the diet, but the difference was not statistically significant (Pincus and Barry, 1987c; Barichella et al, 2016a). The development of dyskinesia also exists in the patients who use LPP during a PRD.…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

“…PD patients are likely to show lower body mass index (BMI) than healthy individuals (van der Marck et al, 2012), and their BMI is inversely associated with disease severity (van der Marck et al, 2012; Barichella et al, 2016a; Wills et al, 2016). Thereby, weight loss is another major concern regarding side effects of PRD.…”

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

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Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Wang

Xiong

Huang

et al. 2017

Front. Aging Neurosci.

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Levodopa is considered to be the most effective symptomatic drug for Parkinson's disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable “on-off”). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet (LPD), protein-redistribution diet (PRD) and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition (e.g., protein and calcium insufficiency). Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects.

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Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 97%

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 98%

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

Section: Clinical Effects Of Protein-restricted Dietsmentioning

confidence: 99%

See 3 more Smart Citations

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Wang

Xiong

Huang

et al. 2017

Front. Aging Neurosci.

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Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease

Fernando

Gupta

Jayasena

et al. 2019

Neurodegeneration and Alzheimer's Disease

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The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Rivadeneyra

Verhagen

Bartulos

et al. 2021

Movement Disord Clin Pract

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Background Skeletal muscle loss has been associated with declining physical performance and a negative prognostic effect on falls, disability, and mortality risk in Parkinson's disease. Objectives We aimed to analyze the clinical correlates associated with skeletal muscle wasting in Parkinson's disease. Methods This was a cross‐sectional, case–control, observational study. We collected information on dietary intake with a 24‐hour recall questionnaire, body composition with bioelectrical impedance, motor severity with the Unified Parkinson's disease Rating Scale, and physical activity with the Global Physical Activity Questionnaire. We used multivariate linear regression analysis to analyze the sociodemographic and clinical correlates associated with skeletal muscle loss after adjusting for confounding variables. Results Forty‐three patients with Parkinson's disease and 21 matched family members were included. Patients and family members had similar body composition, anthropometrics, and nutritional parameters. Advanced patients had similar nutrient intakes compared to patients with mild‐to‐moderate Parkinson's disease. In the multivariate linear regression analysis, female patients with low physical activity and low energy intake were more likely to have skeletal muscle loss. Conclusions Skeletal muscle wasting is a complex multifactorial problem. Dietary strategies and physical exercise should be recommended, especially to females with Parkinson's disease, to prevent significant skeletal muscle wasting.

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Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Cited by 79 publications

References 44 publications

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Carbohydrate and Protein Metabolism: Influences on Cognition and Alzheimer's Disease

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

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