Dietary habits and lung cancer risk among non-smoking women

Ak, Kubík; Zatloukal, Petr; Tomášek, Ladislav; Pauk, Norbert; Havel, Libor; Kr̆epela, E; Petruželka, Luboš

doi:10.1097/00008469-200412000-00002

Cited by 59 publications

(43 citation statements)

References 44 publications

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“…In some recent studies, a protective effect of tea consumption against lung cancer was only observed in specific subpopulations. For example, green tea was protective in individuals with the OGG1 Cys (326) allele [70] and nonsmoking women [71], and black tea in nonsmoking women [72,73]. These results point out the importance of considering genetic polymorphism and specific risk factors in future studies.…”

Section: Lung Cancermentioning

confidence: 82%

Inhibition of carcinogenesis by tea constituents

Lǚ

Lambert

et al. 2007

Seminars in Cancer Biology

130

104

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The possible cancer preventive activity of tea has received much attention in recent years. The inhibitory activities of tea and tea constituents against carcinogenesis at different organ sites have been demonstrated in many animal models. The effect of tea consumption on human cancers, however, remains inconclusive. The mechanisms of action of tea polyphenols, especially EGCG, the most abundant and active catechin, have been extensively investigated. Most of the studies, however, were based on cell culture systems, and these mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer. Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents.

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Section: Lung Cancermentioning

confidence: 82%

Inhibition of carcinogenesis by tea constituents

Lǚ

Lambert

et al. 2007

Seminars in Cancer Biology

130

104

View full text Add to dashboard Cite

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“…This is also the conclusion of a recent review, which covers 14 epidemiological studies on green and black tea consumption and lung cancer risk (Clark and You, 2006). In some recent studies, a protective effect of tea consumption against lung cancer was only observed in special subpopulations; for example, green tea in individuals with the Cys(326) allele of 8-oxoguanine-DNA glycosylase (Bonner et al, 2005) and nonsmoking women (Zhong et al, 2001), and black tea in nonsmoking women (Kubik et al, 2004). The results are interesting, but are far from clear because of the many confounding factors.…”

Section: Human Studiesmentioning

confidence: 86%

Tea and cancer prevention: Molecular mechanisms and human relevance

Yang

Lambert

et al. 2007

Toxicology and Applied Pharmacology

237

169

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Tea made from the leaves of the plant Camellia sinensis is a popular beverage. The possible cancer preventive activity of tea and tea polyphenols has been studied extensively. This article briefly reviews studies in animal models, cell lines, and possible relevance of these studies to the prevention of human cancer. The cancer preventive activity of tea constituents have been demonstrated in many animal models including cancer of the skin, lung, oral cavity, esophagus, stomach, liver, pancreas, small intestine, colon, bladder, prostate, and mammary gland. The major active constituents are polyphenols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant, most active, and most studied, and caffeine. The molecular mechanisms of the cancer preventive action, however, are just beginning to be understood. Studies in cell lines led to the proposal of many mechanisms on the action of EGCG. However, mechanisms based on studies with very high concentrations of EGCG may not be relevant to cancer prevention in vivo. The autooxidation of EGCG in cell culture may also produce activities that do not occur in many internal organs. In contrast to the cancer prevention activity demonstrated in different animal models, no such conclusion can be convincingly drawn from epidemiological studies on tea consumption and human cancers. Even though the human data are inconclusive, tea constituents may still be used for the prevention of cancer at selected organ sites if sufficient concentrations of the agent can be delivered to these organs. Some interesting examples in this area are discussed.

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“…Among women, consumption of milk may decrease risk of colorectal cancer (1) and cervical cancer (2), but have no effect on breast cancer e.g., (3)-4) or endometrial cancer (4). Results for lung cancer are quite mixed, with some studies suggesting risk reduction e.g., (5) or risk enhancement e.g., (6) that may vary by gender (7) or the histology of the tumor (8). A recent review on ovarian cancer concluded that consumption of low-fat milk is protective (9), but a pooled analysis of 12 cohort studies observed an elevated risk associated with increased lactose intake (10).…”

Section: Introductionmentioning

confidence: 99%

Unpasteurized milk consumption and subsequent risk of cancer

Sellers

Vierkant

Djeu

et al. 2008

Cancer Causes Control

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Concerns have been raised regarding the possible adverse health effects of consumption of unpasteurized milk and risk of cancer. We examined the association of self-reported intake of unpasteurized milk with subsequent risk of cancer in a large population-based cohort study. The Iowa Women's Health Study is a prospective cohort study of 55-69 year old women at baseline in 1986. Of the 41,836 women in the cohort at baseline, 22,808 cancer-free women completed the fourth follow-up questionnaire in 1997. Risk ratios (RR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression analysis. Reported intake of unpasteurized milk was high: 59.2% consumed only as a child, 2.5% consumed only as an adult, and 16.5% consumed as a child and an adult. A total of 2,379 cancers were identified in the cohort at risk. Overall, the age-adjusted risk of cancer was lower among women who reported consumption of unpasteurized milk only as a child (RR = 0.90, 95% CI: 0.82-0.99) or as a child and an adult (RR = 0.85; 95% CI: 0.75-0.97). Adjustment for confounding factors attenuated these associations (RR = 0.92, 95% CI: 0.83-1.02 for consumption only as a child, and RR = 0.91; 95% CI: 0.79-1.04 for consumption as a child and an adult). These data suggest that consumption of unpasteurized milk does not increase risk of cancer.

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Dietary habits and lung cancer risk among non-smoking women

Cited by 59 publications

References 44 publications

Inhibition of carcinogenesis by tea constituents

Inhibition of carcinogenesis by tea constituents

Tea and cancer prevention: Molecular mechanisms and human relevance

Unpasteurized milk consumption and subsequent risk of cancer

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