Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans

Zunino, Susan J.; Peerson, Jan; Freytag, Tammy; Breksa, Andrew P.; Bonnel, Ellen L.; Woodhouse, Leslie R.; Storms, David H.

doi:10.1017/s0007114514000890

Cited by 59 publications

(81 citation statements)

References 45 publications

(42 reference statements)

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“…47 In this study, dietary grape powder supplementation (46 g grape powder in 240 mL of water, two times per day for 3 weeks, representing four servings of grapes/day) was found to (1) reduce plasma concentrations of large LDL cholesterol and large LDL particles, and (2) increase production of IL-1β and IL-6 in supernatants from lipopolysaccharide-activated peripheral blood mononuclear cells (PBMCs). 47 …”

Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 92%

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Singh

Liu

Ahmad

2015

Annals of the New York Academy of Sciences

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The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole-grape products, have shown considerable promise in health promotion and disease management. Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, the whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy. Recent research has suggested that whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. Based on the available recent literature, the grape or whole-grape products seem to be safer choices for better health and disease prevention. However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients together with existing therapies appear to be better approaches. Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.

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Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 92%

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Singh

Liu

Ahmad

2015

Annals of the New York Academy of Sciences

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“…A similar effect on FMD was observed in adolescents affected by metabolic syndrome [12] and in adults with coronary artery disease [19]. The investigators suggested that the observed effects were due to the enhancement in the nitric oxide (NO) bioactivity, responsible for the positive modulation of endothelial function.…”

Section: Resultsmentioning

confidence: 67%

“…The investigators suggested that the observed effects were due to the enhancement in the nitric oxide (NO) bioactivity, responsible for the positive modulation of endothelial function. Controversial results were observed on the improvement of plasma cholesterol profile (reduction of LDL-cholesterol mediated by an increased expression of LDL receptors) after the intake of grape derivatives (4 studies in favour and 4 without significant difference) [13,15,19,20], while significant …”

Section: Resultsmentioning

confidence: 99%

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Beneficial effects of non-alcoholic grape-derived products on human health: A literature review

Lorenzo

Sousa

Pastor

et al. 2015

BIO Web of Conferences

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Abstract.Vine is widely cultivated due to the economic value of wine and other grape derivatives. The grape berry is characterized by the presence of a wide variety of flavonoids, which have been investigated for their health promoting properties. Several epidemiological studies have shown that a moderate consumption of wine is associated with a J-shaped effect on some risk factors for chronic diseases. On the other hand, the wine market has shown a decreasing trend due to the frequent abuse of alcoholic beverages also by young people, as denounced by WHO. Accordingly, the scientific research in the field of non-alcoholic grape products has been further stimulated. The aim of this paper was a preliminary collection of data on human studies supporting the beneficial properties of unfermented grape products. The most convincing positive effects, observed in humans, consisted in the reduction of risk factors for cardiovascular diseases, such as hypertension and oxidative stress. Other human trials have been published in the area of: immune system, diabetes, cognitive functions, oral health, and cancer. Generally speaking, the findings listed in this review support the use of non-alcoholic grape derivatives, as a source of beneficial compounds for the human diet, even though further studies are necessary.

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“…While no effect was seen in this combined population, investigations of subpopulations and more sophisticated analysis of lipids has been carried out in other studies. One study found that plasma concentrations of large LDL-C and large LDL particles compared with placebo were decreased in obese subjects supplemented with grape powder for 3 weeks (30). However, the most atherogenic small LDL particles were not affected by treatment (85).…”

Section: Polyphenolsmentioning

confidence: 99%

The role of nutraceuticals in the prevention of cardiovascular disease

Sosnowska

Penson

Banach

2017

Cardiovasc. Diagn. Ther.

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IntroductionCardiovascular disease (CVD) is common, indeed the majority of adults above sixty years of age will experience some manifestation of CVD. Based on data from 2012 and 2013, it has been estimated that CVD is responsible for 17.3 million deaths annually worldwide (1). Morbidity is also high, and in Europe, 200 billion Euros of healthcare expenditure is attributable to CVD (2). Risk factors for CVD can be categorized as modifiable and non-modifiable. Modifiable risk factors include obesity, hypertension, hyperlipidemia, diabetes mellitus, metabolic syndrome and lifestyle risk factors such as unhealthy diet, smoking and physical inactivity. Dietary factors are also important contributors to cardiovascular risk, either directly, or through their effects on other risk factors including hypertension, dyslipidemia and diabetes mellitus (3). Reduction of risk factors in the population, especially blood pressure reduction and lipid-lowering can have important impacts upon mortality from CVD (4).Protective effects against CVD have been demonstrated for several foods and dietary supplements (5) thus presenting new possibilities for population-level reduction of CVD risk. Evidence suggests that this approach is very promising. For example, in the PREDIMED observational study, participants in the highest quintile of polyphenol consumption had a relative risk of CVD of 54% compared to those in the lowest quintile (6). The aim of this review is to present an update on the most recent evidence relating to the use of nutraceuticals in the context of the prevention and treatment of CVD. Unfortunately, few studies have measured the associations between nutraceutical consumptions and "hard" outcomes such as mortality. Large randomized controlled trials are particularly rare, and thus there is a paucity of evidence in this area. Thus, our discussion will be largely focused on the effects of NutraceuticalsThe term "nutraceuticals" was introduced by Stephen DeFelice, founder and chairman of the Foundation for Innovation in Medicine, in 1989. A nutraceutical is defined as a "food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease" (7). The definition encompasses medicinal products made from natural ingredients. Several classes of nutraceuticals have been proposed to have potential benefits in the treatment of CVD and the ones with the strongest evidence are briefly summarized below. Sterols/stanolsPlant sterols/stanols are phytosterols, and have been identified in a range of plant products including various fruits and vegetables, cereals, seeds and nuts. Their biological activity results from their molecular structural similarity to cholesterol (8). PolyphenolsPolyphenols are phytochemicals with widespread distribution in foods of plant origin. They are found in fruits, vegetables, cereal and legumes. Additionally, they are found in beverages produced from plant products such as tea, coffee, wine and cocoa. Polyphenols are structurally diverse, and over 8,000 have...

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Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans

Cited by 59 publications

References 45 publications

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Beneficial effects of non-alcoholic grape-derived products on human health: A literature review

The role of nutraceuticals in the prevention of cardiovascular disease

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